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[(,)-343.3(2)0(0)20.8(0)0(3)20.8(\))0(,)-332.8()0(o)21(o)0(r)15.1(s)-340.7(in)-330.6(th)20.7(e)-342.1(a)0(s)19.9(s)0(e)19.9(m)0(b)19.6(l)0(y)-336.4(f)0(a)19.7(c)0(i)19.5(l)0(i)20.6(t)0(y)-330.6(f)0(o)15.1(r)-340.9(th)20.7(e)]TJ -5.7655 -1.1116 TD [(Ma)18.8(rs)-278.4(Ph)21(oe)19.7(ni)20.7(x)-289.1(l)0(a)19.5(n)0(d)20.8(e)0(r)-279.8(\()0(G)20(h)0(o)20.8(s)0(h)]TJ /F7 1 Tf 11.7383 0 TD [(et)-274.2(al)20.7(.)]TJ /F6 1 Tf 2.0044 0 TD -.0203 Tc [(,)-306(2)-20.3(01)-20.3(0\))-20.3(,)-295.5(s)-20.3(u)-5(r)-20.3(fa)-20.3(ce)-20.3(s)-294.2(i)-20.3(n)-299.1(t)-20.3(he)-304.8(a)-20.3(s)-6.2(-)]TJ -13.7427 -1.1116 TD 0 Tc [(se)19.9(mb)19.6(ly)-163.6(fa)19.7(ci)19.6(li)20.6(ti)20.6(es)-164.4(fo)20.9(r)-168.1(t)0(h)15(e)-169.3(He)18.8(rs)21.1(ch)19.7(el)-164.8(sp)21(ac)18.5(ec)18.5(ra)19.7(ft)-163.6(\()-70.2(M)0(o)19.9(i)0(s)15.1(s)0(l)20.9(-)0(E)19.7(i)0(c)19.6(h)0(i)14.9(n)0(g)20.8(e)0(r)]TJ /F7 1 Tf T* [(et)-251.2(al)20.7(.)]TJ /F6 1 Tf 1.9813 0 TD [(,)-256.9(2)0(0)20.8(1)0(3)20.8(\))0(,)-252.2(s)0(u)21(r)0(f)20.9(a)0(c)18.5(e)0(s)-250.8(o)0(f)-249.8(t)0(h)20.7(e)-255.7(In)15.1(te)19.6(rn)20.9(at)19.5(io)20.7(na)13.9(l)-254.7(S)0(p)21(a)0(c)18.5(e)-261.4(St)20.9(at)19.6(io)14.9(n)-254.5(\()0(I)20.9(S)0(S)15.4(\))]TJ -1.9813 -1.1174 TD [(\(C)19.8(as)14.1(tr)20.7(o)]TJ /F7 1 Tf 3.1506 0 TD [(et)-256.9(al)20.7(.)]TJ /F6 1 Tf 1.9813 0 TD [(,)-262.6(2)0(0)15.1(0)0(4)20.8(\))0(,)-252.2(a)0(n)19.7(d)-260.3(in)-255.8(th)20.7(e)-261.4(d)0(r)20.9(i)0(n)15(k)0(i)20.7(n)0(g)-249.9(w)0(a)18.8(t)0(e)13.8(r)-260.3(of)-249.8(th)15(e)-261.4(I)0(S)21(S)-265.9(\(L)19.7(a)]TJ -5.1319 -1.1116 TD [(Du)20(c)]TJ /F7 1 Tf 2.1599 0 TD [(et)-510.3(al)20.7(.)]TJ /F6 1 Tf 2.2405 0 TD [(,)-510.3(2)0(0)15.1(0)0(4)20.8(\))0(.)-505.6(M)0(o)19.9(l)0(e)19.6(c)0(u)19.7(l)0(a)19.6(r)-519.4(co)19.7(mm)18.4(un)20.8(it)20.6(y)-513.7(a)0(n)19.7(a)0(l)19.5(y)0(s)15.3(e)0(s)-504.3(f)0(u)20.9(r)0(t)15(h)0(e)19.7(r)]TJ -4.4004 -1.1116 TD [(su)21(gg)15.1(es)19.9(t)-214.3(t)0(h)20.7(a)0(t)-210.8(t)0(h)20.7(e)-221.1(di)20.7(ve)19.7(rs)21.1(it)14.8(y)-214.2(\()0(a)19.7(n)0(d)20.8(/)0(o)15(r)-214.2(ab)19.7(un)20.8(da)13.9(nc)19.7(e\))-204.9(of)]TJ /F7 1 Tf 18.7766 0 TD [(Ac)18.5(in)20.7(et)19.6(ob)20.8(ac)13.9(te)19.6(r)]TJ /F6 1 Tf -18.7766 -1.1174 TD [(in)20.7(cr)19.7(ea)12.8(se)19.9(s)-455.9(d)0(u)20.8(r)0(i)20.7(n)0(g)-451.5(s)0(p)21(a)0(c)18.5(e)0(c)18.5(r)0(a)19.7(f)0(t)-451.6(a)0(s)19.9(s)0(e)19.9(m)0(b)19.6(l)0(y)20.7(,)-458.4(as)-446.7(wa)18.8(s)-461.7(o)0(b)20.8(s)0(e)19.9(r)0(v)20.9(e)0(d)-446.9(f)0(o)15.1(r)]TJ 0 -1.1116 TD -.02 Tc [(t)-20(h).7(e)-465.8(M)-20(ar)-20(s)-453.9(P)-20(ho)-20(en)-20(ix)-464.6(l)-20(a)-.4(n)-20(d).8(e)-20(r)-.3(,)-461.2(w)-20(he)-20(re)-465.8(t)-20(h).7(e)-465.8(r)-20(el)-20(at)-20(iv)-20(e)-455.3(a)-20(bu)-20(nd)-20(an)-20(ce)-465.8(o)-20(f)]TJ /F7 1 Tf T* 0 Tc [(Ac)18.5(in)20.7(et)19.5(ob)15.1(ac)19.7(te)19.6(r)]TJ /F6 1 Tf 5.9843 0 TD [(am)18.5(on)20.8(g)-461.9(a)0(l)19.5(l)-467.8(ge)19.7(ne)19.7(ra)-458.3(\(i)20.7(n)-467.6(o)0(p)20.8(e)0(r)19.7(a)0(t)19.5(i)0(o)15(n)0(a)19.7(l)-462(ta)19.6(xo)15.1(no)20.8(mi)19.5(c)]TJ -5.9843 -1.1174 TD [(un)20.8(it)20.6(s\))-284.2(in)15(cr)19.7(ea)18.5(se)19.9(d)]TJ /F9 1 Tf 6.5315 0 TD (*)Tj /F6 1 Tf .9907 0 TD [(10)20.8(-f)20.9(ol)15(d)-289.1(u)0(p)20.8(o)0(n)-284.4(c)0(o)19.7(m)0(m)18.4(e)0(n)19.7(c)0(e)18.5(m)0(e)18.4(n)0(t)-284.6(o)0(f)-284.4(a)0(s)19.9(s)0(e)14.1(m)0(b)19.6(l)0(y)]TJ -7.5222 -1.1116 TD [(an)19.7(d)-352.4(e)0(n)19.7(f)0(o)20.9(r)0(c)19.7(e)0(m)18.5(e)0(n)13.9(t)-346.8(of)-342(th)20.7(e)-353.6(s)0(u)21(r)0(f)20.9(a)0(c)18.5(e)-353.6(an)19.7(d)-352.4()0(o)21(o)0(r)-342(c)0(l)19.5(e)0(a)18.5(n)0(i)20.7(n)0(g)-342(p)0(r)20.9(o)0(t)20.7(o)0(c)19.7(o)0(l)14.9(s)]TJ T* [(\(V)20(ai)19.5(sh)15.3(am)18.5(pa)19.7(ya)19.7(n)]TJ /F7 1 Tf 6.4336 0 TD [(et)-251.2(al)20.7(.)]TJ /F6 1 Tf 1.9813 0 TD .2569 Tc [(,2)256.9(0)272(1)256.9(0)277.7(\))256.9(.)]TJ -7.4012 -1.1116 TD -.0172 Tc [(I)4.8(n)-340.8(f)4.8(a)-2.2(ct,)-337.4(f)4.8(or)-335(th)4.7(e)-336.2(M)-1.9(ars)-334.9(P)-.9(h)4.7(o)-1(eni)4.6(x)-340.8(l)4.6(a)-2.2(n)4.7(d)-1(er,)-337.4(p)4.7(hy)4.7(lo)4.7(geneti)4.6(c)-342(c)3.6(hang)4.7(es)]TJ -1.0137 -1.1174 TD -.0174 Tc [(acro)4.5(ss)-346.6(s)4.7(e)-2.4(v)4.5(e)-2.4(ral)-346.9(g)-1.2(enera)-342.2(w)-2.1(ere)-348(q)4.5(uanti)4.4(t)-1.3(ated)-346.8(ov)4.5(er)-346.8(t)4.4(h)-1.2(e)-348(c)3.4(ou)4.5(rs)4.7(e)-348(o)-1.2(f)-346.8(t)4.4(he)]TJ 0 -1.1116 TD -.0177 Tc [(sp)4.2(acecraft)-306.9(assembl)4.1(y)-306.8(pro)4.2(cess)4.4(,)-309.1(w)3.4(hi)4.1(ch)-306.8(i)4.1(n)-1.5(clu)4.2(d)-1.5(ed)-306.8(samp)4.2(lin)4.2(g)-306.8(b)-1.5(efo)4.2(r)-1.5(e,)]TJ T* 0 Tc [(du)20.8(ri)15(ng)20.8(,)-308.7(a)0(n)19.7(d)-312.1(af)19.7(te)19.6(r)-312.1(a)0(s)14.1(s)0(e)19.9(m)0(b)19.6(l)0(y)-301.8(\()0(V)20(a)0(i)19.5(s)0(h)21(a)0(m)18.5(p)0(a)13.9(y)0(a)19.7(n)]TJ /F7 1 Tf 17.4231 0 TD [(et)-303(al)14.9(.)]TJ /F6 1 Tf 2.0332 0 TD -.0204 Tc [(,)-334.9(2)-20.4(01)-20.4(0\))-20.4(.)-324.4(T)-20.4(o-)]TJ -19.4563 -1.1174 TD -.0275 Tc [(gether,)-180.7(t).1(hese)-185.3(net)-184.2(phylogenetic)-185.3(changes)-189.7(\(before)-179.5(vs)-5.4(.)-180.7(a)-1(fter)-184.1(assembly\))]TJ 0 -1.1116 TD -.023 Tc [(sh)4.7(owed)-173.8(\()4.7(1)-1.1(\))-173.8(r)-1(elati)4.6(v)-1.1(e)-175(i)4.6(ncreas)4.9(es)-173.7(i)4.6(n)-179.6(abu)4.7(n)-1.1(d)4.7(a)3.5(nce)-180.8(f)4.7(or)-173.8(t)4.6(h)-1.1(e)]TJ /F7 1 Tf 18.7306 0 TD -.0259 Tc [(Ac)-5.1(inetobac)-5.1(te)-5.1(r)]TJ /F6 1 Tf 5.3104 0 TD 0 Tc (,)Tj /F7 1 Tf -24.041 -1.1116 TD -.0246 Tc (Ralstonia)Tj /F6 1 Tf 3.6171 0 TD .2626 Tc [(,a)289.1(n)284.5(d)]TJ /F7 1 Tf 2.1714 0 TD -.0272 Tc [(Br)-5.1(evu)-5.3(nd)-5.3(im)-6.1(on)-5.3(as)]TJ /F6 1 Tf 6.2378 0 TD [(\()-5.2(a)-.7(l)-5.4(l)-287.6(Gr)-5.2(am-)-5.2(ne)-6.4(ga)-6.4(ti)-5.4(ve)-6.4(\),)-289.8(\(2)-5.3(\))-281.7(r)-5.2(el)-5.4(at)-5.4(iv)-5.3(e)]TJ -12.0263 -1.1174 TD -.0261 Tc [(decrea)-5.3(se)-5.3(s)-470.5(f)-4.1(or)]TJ /F7 1 Tf 5.656 0 TD -.0235 Tc [(Myco)4.2(pl)4.1(an)4.2(a)]TJ /F6 1 Tf 4.2852 0 TD 0 Tc (,)Tj /F7 1 Tf .6969 0 TD -.0277 Tc [(Sp)-5.8(hi)-5.9(ng)-5.8(om)-6.6(on)-5.8(as)]TJ /F6 1 Tf 5.5869 0 TD .4469 Tc [(,a)473.4(n)468.8(d)]TJ /F7 1 Tf 2.54 0 TD -.0245 Tc (Pseudomonas)Tj /F6 1 Tf 5.2759 0 TD 0 Tc (,)Tj -24.041 -1.1116 TD -.0214 Tc [(an)6.3(d)-310.5(\()6.3(3\))]TJ /F8 1 Tf 3.0872 0 TD 0 Tc (<)Tj /F6 1 Tf .5299 0 TD -.0276 Tc [(1%)-317.7(or)-316.6(no)-316.7(ne)-6.8(t)-311.1(c)-6.8(han)-5.7(g).1(e)-6.8(s)-316.5(fo)-5.7(r)-310.9(m)-1.1(o)-5.7(s)-5.5(t)-311.1(G)-6.5(ra)-6.8(m-p)-5.7(o).1(s)-5.5(i)0(t)-5.8(i)0(v)-5.7(e)-312.1(g)-5.7(e)-1.1(n)-5.7(e)-1.1(r)-5.6(a)]TJ -3.6171 -1.1116 TD -.0231 Tc [(su)4.6(ch)-266.1(as)]TJ /F7 1 Tf 3.0584 0 TD -.0275 Tc [(St)-5.7(re)-6.7(pt)-5.7(oc)-6.7(oc)-6.7(cu)-5.6(s)]TJ /F6 1 Tf 5.5696 0 TD [(a)-6.7(n).2(d)-270.5(t)-5.7(he)-277.4(sp)-5.6(or)-5.5(e-)-5.5(f)-34.3(o)-40.1(r)-40.1(m)-35.6(i)-40.2(n)-34.4(g)]TJ /F7 1 Tf 8.9909 0 TD .0094 Tc (Bacillus)Tj /F6 1 Tf 3.3694 0 TD 0 Tc (.)Tj -19.9747 -1.1174 TD [(In)-365(further)-366(detail,)-364.1(and)-367.3(as)-360.3(a)-365.1(comparative)-369.6(e)20.8(x)21.9(a)20.8(m)20.7(p)21.9(l)21.8(e)20.8(,)-343.3(t)21.8(h)21.9(e)]TJ /F7 1 Tf 21.668 0 TD -.0211 Tc (Aci-)Tj -22.6817 -1.1116 TD -.0215 Tc (netobacter)Tj /F6 1 Tf 4.3255 0 TD (and)Tj /F7 1 Tf 1.6358 0 TD (Streptococcus)Tj /F6 1 Tf 5.3392 0 TD [(,)-255.2(r).6(espectively,)-249.5(increased)]TJ /F9 1 Tf 9.3998 0 TD 0 Tc (*)Tj /F6 1 Tf .9792 0 TD -.0216 Tc [(10)-253.1(and)]TJ /F9 1 Tf -21.6795 -1.1116 TD 0 Tc (*)Tj /F6 1 Tf .9791 0 TD -.0218 Tc [(100-fold)-259(during)-253.3(t)0(he)-260.2(assembly)-253.3(process)-258.8(\(from)]TJ /F9 1 Tf 17.0257 0 TD 0 Tc (*)Tj /F6 1 Tf .9792 0 TD -.0219 Tc [(4%)-260.2(to)]TJ /F9 1 Tf 2.54 0 TD 0 Tc (*)Tj /F6 1 Tf .9791 0 TD -.0219 Tc (38%)Tj -22.5032 -1.1116 TD -.0217 Tc [(and)-362.6(from)]TJ /F9 1 Tf 3.9627 0 TD 0 Tc (*)Tj /F6 1 Tf .9792 0 TD -.0225 Tc [(0.4%)-364.5(to)]TJ /F9 1 Tf 3.4501 0 TD 0 Tc (*)Tj /F6 1 Tf 9.843 0 0 9.843 154.2614 177.222 Tm -.0216 Tc [(55%,)-359.1(r).4(espectively\),)-359.1(likely)-362.5(due)-357.9(to)-362.5(con-)]TJ -9.371 -1.1174 TD [(tamination)-610.2(a)-.8(rising)-610.2(from)-611.4(i).2(ncreased)-610.2(personnel)-610.3(a)-.8(nd)-610.2(activities)]TJ 0 -1.1116 TD [(within)-339.5(the)-340.6(f).4(acilities.)-336.1(However,)-336(after)-339.4(a)-.8(ssembly,)-336.1(a)-.8(nd)-339.5(despite)-340.6(the)]TJ T* -.0214 Tc [(routine)-634.2(c)-.6(leaning)-633(p).5(rocedures,)-629.6(t).4(he)]TJ /F7 1 Tf 14.0249 0 TD (Acinetobacter)Tj /F6 1 Tf 5.9843 0 TD -.0217 Tc [(fur)-5.5(t).1(her)-633.3(i).1(n-)]TJ -20.0092 -1.1174 TD -.0213 Tc [(creased)-379.5(to)]TJ /F9 1 Tf 4.3601 0 TD 0 Tc (*)Tj /F6 1 Tf .9792 0 TD -.0219 Tc [(48%)-381.2(\(or)-380.1(a)-381.3(n)-5.7(e)4.6(t)]TJ /F9 1 Tf 5.9843 0 TD 0 Tc (*)Tj /F6 1 Tf .9791 0 TD -.0216 Tc [(10-fold)-379.8(increase\))-385.5(to)-379.8(ultimately)]TJ -12.3027 -1.1116 TD [(represent)-535.4(t).2(he)-536.5(numerically)-529.5(dominant)-535.4(g).3(enus)-535.1(within)-535.3(the)-536.5(post-)]TJ T* [(assembly)-425.9(community.)-428.2(I).4(n)-425.9(c)-.8(ontrast,)-428.2(t).2(he)]TJ /F7 1 Tf 15.4763 0 TD -.0221 Tc [(Str)-5.7(e)-1.3(ptococcus)]TJ /F6 1 Tf 5.7712 0 TD -.0213 Tc (reduced)Tj /F9 1 Tf -21.2476 -1.1174 TD 0 Tc (*)Tj /F6 1 Tf .9791 0 TD -.0217 Tc [(180-fold)-333.8(in)-333.8(abundance)-335(a)4.8(nd)-333.8(reduced)-333.8(to)-333.8(0.3%.)]TJ .0346 -1.1116 TD 0 Tc [(These)-245(observations)-251.5(of)-244.1(a)-244.2(dynamic)-247.5(and)-246.4(persistent)-249.5(spacecraft)]TJ -1.0137 -1.1116 TD [(microbial)-417(community)-411.2(support)-416.6(the)-413.5(hypothesis)-415.2(that)-409(the)-413.5(core)]TJ 0 -1.1174 TD [(microbiome)-505.6(is)-503.2(composed)-501.8(of)-503.3(members)-501.8(that)-506.9(harbor)-497.3(a)-503.3(bio-)]TJ 0 -1.1116 TD [(chemical)-377.8(potential)-375.6(to)-370.9(tolerate)-375.5(the)-373.2(cleaning)-375.4(procedures,)-374.8(and)]TJ 25.504 67.9184 TD [(survive)-337.1(the)-338.7(oligotrophic)-337.4(and)-332.8(low-humidity)-338.4(environments)-339.4(of)]TJ 0 -1.1174 TD [(the)-361.7(assembly)-357.7(facilities)-360.5(\(La)-362.7(Duc)]TJ /F7 1 Tf 13.2761 0 TD [(et)-354.8(al.)]TJ /F6 1 Tf 2.1138 0 TD [(,)-360.5(2007,)-353.4(2012;)-357(Moissl-)]TJ -15.3899 -1.1116 TD (Eichinger)Tj /F7 1 Tf 4.3255 0 TD [(et)-418.2(al.)]TJ /F6 1 Tf 2.1772 0 TD [(,)-418.1(2013\).)-417.9(Accordingly,)-416.4(the)-419.3(objective)-422.7(of)-416.9(this)]TJ -6.5027 -1.1116 TD -.0172 Tc [(wo)4.7(rk)-340.8(was)-346.4(t)4.6(o)-340.8(m)3.5(eas)4.9(u)-1(r)4.8(e)-342(th)4.7(e)-342(a)3.6(bi)4.6(l)4.6(i)]TJ 11.9975 0 TD -.0199 Tc [(ty)-343.5(of)-343.5(space)-4.9(cra)-4.9(f)2.1(t-assoc)-4.9(i)1.9(ated)]TJ /F7 1 Tf 10.6785 0 TD -.0213 Tc [(Ac)-6.3(i-)]TJ -22.676 -1.1116 TD -.0217 Tc [(n)-5.5(e)-.9(t)-5.7(oba)-5.5(cte)-6.7(r)]TJ /F6 1 Tf 4.5041 0 TD [(to)-414.4(met)-5.5(a)-.8(bo)-5.4(liz)-6.6(e)-409.8(a)-.8(n)-5.4(d)-408.6(bi)-5.6(ode)-6.6(gra)-6.6(d).3(e)-409.8(s)-5.2(pac)-6.6(ecr)-5.4(aft)-414.5(c)-.8(le)-6.6(ani)-5.5(n).3(g)]TJ -4.5041 -1.1174 TD [(r)-5.4(e)-.8(a)-6.6(g).3(en)-5.4(ts,)-445.5(a)-.8(nd)-443.2(su)-5.4(rv)-5.4(ive)-444.3(u).3(n)-5.4(d).3(er)-443.1(ex)-5.4(tr)-5.4(eme)-444.3(c)-.8(on)-5.4(dit)-5.5(i).2(o)-5.4(n).3(s,)-445.5(whe)-6.6(n)-437.4(c)-6.6(u).3(lt)-5.6(i-)]TJ 0 -1.1116 TD -.0173 Tc [(vated)-329.4(u)4.6(nd)4.6(er)-335.1(n)4.6(u)4.6(t)-1.2(r)4.7(i)4.5(en)4.6(t)4.5(-)-1.1(r)4.7(e)-2.3(s)4.8(t)4.5(ri)4.5(ct)4.5(ed)-329.4(co)4.6(n)4.6(d)-1.1(i)4.5(t)-1.3(i)4.5(o)4.6(ns)4.8(.)]TJ /F5 1 Tf 8.9663 0 0 8.9663 313.0582 634.7337 Tm 0 Tc [(2.)-501.1(Materials)-339(and)-331.9(Methods)]TJ /F3 1 Tf 0 -1.8336 TD [(2.1.)-502.8(Materials)]TJ /F6 1 Tf 9.843 0 0 9.843 323.0361 601.8518 Tm (Spacecraft-associated)Tj /F7 1 Tf 8.9333 0 TD (Acinetobacter)Tj /F6 1 Tf 5.8634 0 TD [(strains)-233.3(were)-232.2(obtained)]TJ -15.8104 -1.1116 TD [(from)-368.4(the)-367.5(Planetary)-370.6(Protection)-370.6(Culture)-367.2(Collection)-366.2(at)-372.1(the)-361.7(Jet)]TJ 0 -1.1174 TD [(Propul)-6.6(sion)-321.1(Laboratory)-325.6(\(Pasadena,)-328.6(CA\))-322(and)-327(included)]TJ /F7 1 Tf 21.668 0 TD (Acine-)Tj -21.668 -1.1116 TD [(tobacter)-546.9(radioresistens)]TJ /F6 1 Tf 10.091 0 TD (50v1,)Tj /F7 1 Tf 2.7877 0 TD [(Acinetobacter)-544.5(proteolyticus)]TJ /F6 1 Tf -12.8787 -1.1116 TD [(2P01AA)-440.2(\(formerly)-444.3(assigned)-437.1(as)]TJ /F7 1 Tf 13.3683 0 TD [(Acinetobacter)-440.8(gyllenbergii)]TJ /F6 1 Tf -13.3683 -1.1116 TD (2P01AA\),)Tj /F7 1 Tf 4.579 0 TD [(Acinetobacter)-509.9(johnsonii)]TJ /F6 1 Tf 10.3732 0 TD (2P08AA,)Tj /F7 1 Tf 4.2449 0 TD [(A.)-501.1(johnsonii)]TJ /F6 1 Tf -19.1971 -1.1174 TD (2P07AA,)Tj /F7 1 Tf 4.3371 0 TD [(Acinetobacter)-596.3(oryzare)]TJ /F6 1 Tf 9.8721 0 TD (2P08MC,)Tj /F7 1 Tf 4.4465 0 TD (Acinetobacter)Tj -18.6557 -1.1116 TD (guillouiae)Tj /F6 1 Tf 4.4177 0 TD [(2P07PB,)-339.1(and)]TJ /F7 1 Tf 5.6503 0 TD [(A.)-339.8(guillouiae)]TJ /F6 1 Tf 5.6157 0 TD [(2P07PC.)-344.8(The)-339.7(control)]TJ -15.6837 -1.1116 TD [(type)-270.6(strain,)]TJ /F7 1 Tf 4.7518 0 TD [(A.)-264.9(radioresistens)]TJ /F6 1 Tf 7.0672 0 TD (43998)Tj 7.3823 0 0 6.5614 453.9967 518.5699 Tm (T)Tj 9.843 0 0 9.843 458.5322 514.2046 Tm [(,)-268.4(was)-270.1(obtained)-276.3(from)-270.5(the)]TJ -14.7794 -1.1174 TD -.0158 Tc [(A)-15.8(m)8.7(eric)-15.8(a)8.5(n)-270.3(Type)-277.2(Cultu)-15.8(r)10.8(e)-271.5(Col)-15.8(l)10.5(ecti)-15.8(o)10.7(n.)]TJ 1.0137 -1.1116 TD -.0198 Tc [(The)-292.8(s)-3.4(pa)-4.8(cecraft)-291.7(c)-4.8(lea)-4.8(n)2.1(ing)-291.6(r)-3.6(eagen)]TJ 12.0666 0 TD -.0202 Tc [(ts)-291.8(of)-292(e)-5.2(t)1.6(ha)-5.2(nol)-297.9(\(O)-4.9(mnipur)-297.7(Pure)-5.2(,)]TJ -13.0803 -1.1116 TD -.0215 Tc [(2)-5.3(0).4(0)-431.5(p).4(ro)-5.3(of)-5.3(;)-425.9(V)-.4(WR)-6.3(\),)-428.1(2)-5.3(-).5(pr)-5.3(opa)-6.5(nol)-431.7(\(F)-5.2(is)-5.1(her)-431.5(S).6(ci)-5.5(.\),)-428.1(a)-.7(n)-5.3(d)-425.8(K)-6.2(l).3(ee)-6.5(nol)-431.7(3).4(0)]TJ 0 -1.1174 TD [(\()-86(M)-6.3(iss)-5.2(i).2(o)-5.4(n)-495(Lab)-5.4(o).3(ra)-6.6(tor)-5.4(i).2(e)-6.6(s).5(,)-497.3(L)-.8(os)-500.6(Ang)-5.4(e)-.8(le)-6.6(s,)-497.3(CA;)-495.1(C)-6.4(lov)-5.4(i).2(s)-494.8(J)-5.2(an)-5.4(ito)-5.4(ria)-6.6(l).2(\))]TJ 0 -1.1116 TD -.0218 Tc [(w)-6.5(e)-1(r)-5.6(e)-329.3(st)-5.8(er)-5.6(ile)-335.1(lt)-5.8(e)-1(r)-5.6(e)-1(d,)-330.5(w)-6.5(ith)-5.6(out)-334.1(di)-5.7(lut)-5.8(i)0(on)-5.6(,)-330.5(a)-1(n)-5.6(d)-328.2(sa)-6.8(ved)-333.9(a)-1(s)-333.7(a)-1(li)-5.7(qu)-5.6(ots)-333.7(a)-1(t)]TJ T* 0 Tc (4)Tj /F8 1 Tf .4838 0 TD ()Tj /F6 1 Tf .3744 0 TD -.0198 Tc [(C.)-466.7(Conce)-4.8(n)2.1(trated)-464.4(5)]TJ /F8 1 Tf 7.5682 0 TD 0 Tc ()Tj /F6 1 Tf .7027 0 TD -.0202 Tc [(minimal)-470.7(m).5(edium)-466(\()-84.6(M9\))-464.8(w).9(as)-470.4(pre)-5.2(p)1.7(ared)]TJ -9.1291 -1.1116 TD -.0174 Tc [(us)4.7(in)4.5(g)-277.7(6)4.5(4.)8(0)-168.2(g)-277.7(Na)]TJ 7.3823 0 0 6.5614 372.8125 435.855 Tm 0 Tc (2)Tj 9.843 0 0 9.843 376.3275 437.4991 Tm -.0187 Tc (HPO)Tj 7.3823 0 0 6.5614 395.3196 435.855 Tm 0 Tc (4)Tj /F12 1 Tf 9.843 0 0 9.843 398.8345 437.4991 Tm ($)Tj /F6 1 Tf .4493 0 TD -.0219 Tc (7H)Tj 7.3823 0 0 6.5614 414.8219 435.855 Tm 0 Tc (2)Tj 9.843 0 0 9.843 418.3369 437.4991 Tm -.0156 Tc [(O)-276.8(\()6.4(Am)5.1(r)6.4(e)-.6(s)6.5(c)5.2(o\))6.4(,)-272.5(1).6(5)6.3(.)4(0)-160.7(g)-275.9(KH)]TJ 7.3823 0 0 6.5614 512.6739 435.855 Tm 0 Tc (2)Tj 9.843 0 0 9.843 516.1888 437.4991 Tm -.0221 Tc (PO)Tj 7.3823 0 0 6.5614 528.2644 435.855 Tm 0 Tc (4)Tj 9.843 0 0 9.843 534.5574 437.4991 Tm -.0214 Tc (\(EM)Tj -22.5032 -1.1174 TD -.0202 Tc [(Scienc)-5.2(e\),)-490.2(2)1.7(.5)-171(g)-487.8(N).9(aC)-5(l)-488(\()1.8(E)-5.2(M)-488.7(Scienc)-5.2(e\),)-490.2(a).6(nd)-487.8(5.0)-171(g)-487.8(NH)]TJ 7.3823 0 0 6.5614 517.266 424.8566 Tm 0 Tc (4)Tj 9.843 0 0 9.843 520.7809 426.5007 Tm -.0211 Tc [(Cl)-494.6(\(EM)]TJ -21.1036 -1.1116 TD -.0214 Tc [(S)-5.1(c)-.6(i)-5.3(e)-.6(nc)-6.4(e\))-189.5(per)-189.5(l).4(i)-5.3(t).4(er)-189.5(wa)-6.4(ter)-5.2(.)-186.1(To)-189.5(a)-190.7(200)-172.2(mL)-185(a)-6.4(liq)-5.2(uo)-5.2(t)-183.9(o)-5.2(f)-183.7(5)]TJ /F8 1 Tf 18.6442 0 TD 0 Tc ()Tj /F6 1 Tf .6969 0 TD -.0207 Tc [(M9)-188.8(medium)-5.7(,)]TJ -19.3411 -1.1116 TD -.0179 Tc [(2.0)-163(m)2.8(L)-365.8(o)4(f)-364.5(1)-163(M)-359.7(M)-2.6(g)4(S)4.2(O)]TJ 7.3823 0 0 6.5614 398.6078 402.9731 Tm 0 Tc (4)Tj 9.843 0 0 9.843 405.6944 404.6172 Tm -.0195 Tc [(\(EM)-367.1(S)2.6(cience\))-366.1(and)-366.2(1)2.4(00)]TJ /F9 1 Tf 9.1579 0 TD 0 Tc (m)Tj /F6 1 Tf .5299 0 TD .3479 Tc [(L1)202.8(M)6.1(C)363(a)368.7(C)368.8(l)]TJ 7.3823 0 0 6.5614 548.5038 402.9731 Tm 0 Tc (2)Tj 9.843 0 0 9.843 313.0582 393.6188 Tm -.0198 Tc [(\(EM)-263.7(S)2.3(cienc)-4.8(e)1(\))-257(w)-4.5(ere)-264(a)1(dded,)-259.4(a)1(nd)-262.8(the)-258.2(t)2(otal)-262.9(solution)-257(wa)-4.8(s)-256.8(d)-3.6(iluted)-262.8(t)2(o)]TJ 0 -1.1116 TD -.0216 Tc [(1)-172.4(L)-190.9(u)-5.4(s).5(in)-5.4(g)-189.7(w)-6.3(ate)-6.6(r)-189.7(to)-195.5(yi)-5.5(eld)-195.5(1)]TJ /F8 1 Tf 9.6936 0 TD 0 Tc ()Tj /F6 1 Tf .6969 0 TD -.0215 Tc [(M)-6.2(9).4(;)-195.5(i).3(n)-195.4(t).3(ur)-5.3(n,)-192(th)-5.3(is)-195.2(med)-5.3(i).3(um)-196.6(was)-195.2(f).5(u)-5.3(r).5(th)-5.3(er)]TJ -10.3905 -1.1116 TD -.0179 Tc [(di)3.9(lu)4(t)3.9(e)-2.9(d)-186()4.2(vef)4.1(o)-1.7(l)3.9(d)-186(to)-186(y)4(i)-1.9(el)3.9(d)-191.8(0)4(.2)]TJ /F8 1 Tf 10.3963 0 TD 0 Tc ()Tj /F6 1 Tf .7027 0 TD -.0189 Tc [(M9)3(.)-189.4(L)1.9(ys)3.2(o)3(g)-2.7(en)3(y)-192.8(b)3(ro)3(t)2.9(h)-192.8(\()3.1(L)1.9(B\))-192.8(medi)2.9(u)3(m)]TJ -11.099 -1.1174 TD -.0213 Tc [(w)-6(a)-.5(s)-183.5(p).6(r)-5.1(e)-.5(p)-5.1(a)-.5(re)-6.3(d)-183.7(u).6(si)-5.2(ng)-183.7(10)-5.1(.0)-166.4(g)-183.7(t).5(r)-5.1(ypt)-5.2(one)-184.8(\()-5.1(V)-.2(WR)-184.7(Amr)-5.1(e)-.5(s)-4.9(c)-.5(o\))-5.1(,)-180.2(5)-5.1(.0)-166.4(g)-183.7(y).6(ea)-6.3(st)]TJ 0 -1.1116 TD -.0215 Tc [(\()-5.3(B)-.6(ec)-6.5(to)-5.3(n,)-249.6(Dic)-6.5(k).4(in)-5.3(so)-5.3(n)-247.2(a)-.7(nd)-253(Comp)-5.3(an)]TJ 12.608 0 TD -.0198 Tc [(y\),)-247.9(1)2.1(0.0)-164.9(g)-245.5(Na)-4.8(Cl)-245.7(\(E)-4.8(M)-246.4(S)2.3(c)-4.8(i)2(ence\),)]TJ -12.608 -1.1116 TD -.0211 Tc [(a)-6.1(n).8(d)-269.9(1)-4.9(.0)-166.2(mL)-271.1(o)-4.9(f)-269.8(1)-166.2(M)-270.8(N)-5.8(a)-.3(OH)-276.5(\(Si)-5(g).8(ma)-6.1(-Al)-5.1(d).8(ri)-5(ch)-4.9(\))-269.8(p).8(er)-275.6(lit)-5.1(er)-269.8(o)-4.9(f)-269.8(wa)-6.1(ter)-4.9(.)]TJ 1.0137 -1.1174 TD -.0213 Tc [(Ag)6.4(ar)-373.7(p)6.4(l)6.3(at)6.3(es)-373.5(w)5.5(e)-.5(r)6.4(e)-374.9(pr)6.4(ep)6.4(a)5.2(r).7(e)5.2(d)-373.7(us)6.6(in)6.4(g)-373.7(1)-166.4(L)-369.2(L)-.6(B)-374.8(m)5.2(e)5.2(d).6(i)6.3(u).6(m)-369.2(a)-.5(n)6.4(d)-373.7(15)-160.6(g)]TJ -1.0137 -1.1116 TD -.023 Tc [(of)-738.3(b)4.7(a)-2.2(ct)4.6(er)4.7(io)4.7(lo)4.7(gi)4.6(cal)-738.4(a)3.5(gar)-738.3(\()-1(AMRESCO\))4.7(.)-734.9(St)4.6(ock)-738.3(s)4.9(ol)4.6(ut)4.6(io)4.7(ns)-738.1(o)4.7(f)]TJ T* -.0216 Tc [(10)-160.9(mM)-444.1(Fe)]TJ 7.3823 0 0 6.5614 353.7637 310.3369 Tm 0 Tc (2)Tj /F8 1 Tf .4685 0 TD (+)Tj /F6 1 Tf 9.843 0 0 9.843 365.4991 305.9716 Tm -.0273 Tc [(we)-6.5(re)-455.8(pr)-5.3(ep)-5.4(ar)-5.3(ed)-454.6(by)-454.6(fu)-5.4(ll)-5.5(y)-448.9(d)-5.4(is)-5.2(so)-5.4(lv)-5.4(in)-5.4(g)-448.9(0)-5.4(.19)-5.4(6).4(0)-5.4(7)-166.6(g)-454.6(o).4(f)]TJ -5.3277 -1.1116 TD -.0244 Tc (Fe\(NH)Tj 7.3823 0 0 6.5614 339.1369 293.3858 Tm 0 Tc (4)Tj 9.843 0 0 9.843 342.5952 295.0298 Tm (\))Tj 7.3823 0 0 6.5614 345.5999 293.3858 Tm (2)Tj 9.843 0 0 9.843 349.0582 295.0298 Tm -.022 Tc [(\(S)5.9(O)]TJ 7.3823 0 0 6.5614 364.1385 293.3858 Tm 0 Tc (4)Tj 9.843 0 0 9.843 367.5967 295.0298 Tm (\))Tj 7.3823 0 0 6.5614 370.6014 293.3858 Tm (2)Tj /F12 1 Tf 9.843 0 0 9.843 374.0598 295.0298 Tm ($)Tj /F6 1 Tf .4493 0 TD -.0277 Tc (6H)Tj 7.3823 0 0 6.5614 389.9904 293.3858 Tm 0 Tc (2)Tj 9.843 0 0 9.843 393.4487 295.0298 Tm -.0272 Tc [(O)-472.7(\().5(E)-6.4(M)-472.7(Sc)-6.4(ie)-6.4(nc)-6.4(e\))-471.8(i)-5.4(n)-471.8(50)-5.3(.0)-166.5(m)-6.5(L)-473(wat)-5.4(e)-.7(r)-5.2(,)-474.1(fo)-5.3(l-)]TJ -8.1673 -1.1174 TD -.0225 Tc [(lo)5.2(wed)-219.4(b)5.2(y)-213.7(s)-.4(teri)5.1(le)-214.8()5.4(l)-.7(t)5.1(r)-.5(ati)5.1(o)-.6(n)5.2(,)-216(an)5.2(d)-213.7(s)-.4(t)5.1(o)-.6(r)5.2(a)-1.7(g)5.2(e)-220.6(as)-213.5(al)5.1(iq)5.2(uo)5.2(ts)-213.5(at)-213.8(4)]TJ /F8 1 Tf 19.9862 0 TD 0 Tc ()Tj /F6 1 Tf .3744 0 TD -.0258 Tc [(C.)-219.3(B)-4.9(u)1.9(ffe)-5(r)1.9(s)]TJ -20.3606 -1.1116 TD -.0224 Tc [(in)5.3(cl)5.2(ud)5.3(ed)-829.9(4)5.3(-\(2)5.3(-h)5.3(yd)5.3(ro)5.3(xy)5.3(eth)5.3(y)-.5(l)5.2(\)-1)5.3(-p)5.3(ip)5.3(erazi)5.2(n)-.5(eet)5.2(h)-.5(anesu)5.3(l)-.6(f)5.3(o)-.5(n)5.3(i)-.6(c)-831(a)4.1(ci)5.2(d)]TJ T* -.027 Tc [(\()-5(H)-.2(E)-6.2(P).9(E)-6.3(S).9(;)-679.1(V)-5.9(WR)-6.1(\))-678.9(a)-.5(n)-5.1(d)-678.9(ph)-5.1(os)-4.9(ph)-5.1(at)-5.2(e-)-5(bu)-5.1(ff)-5(er)-5(ed)-678.9(s)-4.9(a)-.5(l)-5.2(i).6(n)-5.1(e)-680.1(\(P)-4.9(BS)-4.9(,)-681.3(G)-.2(-)]TJ 0 -1.1174 TD -.0273 Tc [(B)-6.4(i).3(o)-5.4(s).6(c)-6.5(i).3(e)-6.5(n).4(c)-6.5(e)-.8(s)-5.2(\)).4(.)-192(Tem)-6.6(po)-5.4(ra)-6.5(l)-184(c)-6.5(ha)-6.5(ng)-5.4(es)-189.5(in)-189.7(ce)-6.5(ll)-189.8(de)-6.5(ns)-5.2(it)-5.5(y)-189.7(w)-.5(e)-6.5(r).4(e)-190.8(f).4(o)-5.4(l).3(l)-5.5(o).4(w)-6.2(e)-.8(d)-189.7(b).4(y)]TJ 0 -1.1116 TD [(o)-5.4(p).4(t)-5.5(i).3(c)-6.5(a)-.8(l)-397.2(d).4(e)-6.5(n).4(s)-5.2(i).3(t)-5.5(y)-391.3(\(O)-6.2(D\))-397(mea)-6.5(su)-5.4(re)-6.5(me)-6.5(nt)-5.5(s)-391.1(a)-.8(t)-397.2(6).4(0)-5.4(0)-166.6(nm)-398.2(\(S)-5.2(pe)-6.5(ctr)-5.3(o).4(n)-5.4(i).3(c)-398.2(2).4(0)]TJ T* -.0231 Tc [(Genesy)4.6(s\),)-210.8(a)-2.3(n)4.6(d)-220(b)4.6(y)-220(p)4.6(l)-1.3(at)4.5(e)-221.2(c)3.4(ou)4.6(nt)4.5(s,)-216.6(whi)4.5(c)-2.3(h)-214.3(w)3.7(er)4.6(e)-221.2(e)3.4(xp)4.6(ress)4.8(ed)-214.3(as)-219.8(cfu)4.6(/)-1.3(mL.)]TJ 0 -1.1174 TD -.0253 Tc [(A)-4.2(l)2.3(l)-331.8(m)1.2(icrobiology)-331.7(media)-332.8(we)-4.5(re)-332.8(autoclaved)-331.7(at)-326(121)]TJ /F8 1 Tf 18.6787 0 TD 0 Tc ()Tj /F6 1 Tf .3686 0 TD -.0216 Tc [(C)-329(f)6.1(or)-322.2(30)-160.9(mi)6(n,)]TJ -19.0473 -1.1116 TD -.0233 Tc [(bu)4.4(ffers)-346.7(an)4.4(d)-346.9(m)-2.6(etal)-347.1(so)4.4(lu)4.4(ti)4.3(on)4.4(s)-346.7(w)-2.2(ere)-342.3(s)-1.2(teri)4.3(le)-342.3(l)4.3(tered)-346.9(u)-1.4(s)4.6(i)-1.5(n)4.4(g)-346.9(0.2)4.4(2)]TJ /F9 1 Tf 22.987 0 TD 0 Tc (m)Tj /F6 1 Tf .5241 0 TD (m)Tj -23.5111 -1.1116 TD -.0224 Tc [(cell)5.2(ul)5.2(os)5.5(e)-456.6(a)-1.6(cet)5.2(a)4.1(te)-456.6()5.5(l)-.6(t)5.2(e)-1.6(r)5.3(s)-455.3(\(VWR)]TJ 12.0493 0 TD -.0234 Tc [(\),)-453(and)-456.5(u)4.3(lt)4.2(rapu)4.3(re)-457.6(water)-456.4(\()-1.4(1)4.3(8)-168.5(M)]TJ /F9 1 Tf 11.5252 0 TD 0 Tc (O)Tj /F6 1 Tf -23.5745 -1.1116 TD -.0208 Tc (cm)Tj /F8 1 Tf 7.3823 0 0 6.5614 324.6802 189.8078 Tm 0 Tc (-)Tj /F6 1 Tf .5222 0 TD (1)Tj 9.843 0 0 9.843 331.9936 185.4425 Tm -.0274 Tc [(\))-351(w)-.6(a)-6.6(s)-345.1(u)-5.5(s)-5.3(ed)-351(th)-5.5(ro)-5.5(ug)-5.5(ho)-5.5(ut)-5.6(.)-347.6(S)-5.3(ol)-5.6(ut)-5.6(ion)-5.5(s)-350.8(of)-351(2)-5.5(0)-166.7(mM)-351.9(n)-5.5(i).2(c)-6.6(o).3(ti)-5.6(na)-6.6(mi)-5.6(de)]TJ -1.9237 -1.1174 TD .013 Tc [(adenine)-380.9(d)6.1(inucleotid)6.1(e)-380.9(\().4(NAD)]TJ /F8 1 Tf 7.3823 0 0 6.5614 427.4644 178.8094 Tm 0 Tc (+)Tj /F6 1 Tf 9.843 0 0 9.843 431.6597 174.444 Tm .0127 Tc 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(10)Tj 7.3823 0 0 6.5614 83.6787 510.3495 Tm 0 Tc (8)Tj 9.843 0 0 9.843 89.2913 505.9841 Tm .013 Tc [(cf)6.2(u/)6(mL)5(\))-189.7(o)6.1(r)-183.9(l).3(a)5(t).3(e-)6.2(lo)6.1(g)-189.7(p)6.1(ha)5(se)-185.1(\(O)5.3(D)]TJ /F9 1 Tf 12.441 0 TD 0 Tc (*)Tj /F6 1 Tf 1.0137 0 TD .0119 Tc [(0)5(.)2.7(60)5(.7,)]TJ /F9 1 Tf 3.5192 0 TD 0 Tc (*)Tj /F6 1 Tf 1.0079 0 TD (5)Tj /F8 1 Tf .6739 0 TD ()Tj /F6 1 Tf .7315 0 TD .0126 Tc (10)Tj 7.3823 0 0 6.5614 290.1543 510.3495 Tm 0 Tc (8)Tj 9.843 0 0 9.843 293.9527 505.9841 Tm ()Tj -23.7933 -1.1174 TD (7)Tj /F8 1 Tf .6796 0 TD ()Tj /F6 1 Tf .7257 0 TD .0126 Tc (10)Tj 7.3823 0 0 6.5614 83.6787 499.4077 Tm 0 Tc (8)Tj 9.843 0 0 9.843 90.5952 494.9857 Tm .0134 Tc [(c)5.4(f).8(u)6.5(/).7(m)5.3(L)-.4(\))6.6(.)-318.3(F)6.7(r).8(e)5.4(s)1(h)-316(m)5.3(ed)6.5(iu)6.5(m)-317.2(w)5.7(as)-315.8(i)6.4(n).8(o)6.5(c)-.4(ul)6.4(at)6.4(ed)-310.2(wit)6.4(h)-316(1)6.5(:).7(1)6.5(0).8(0)]TJ -3.1333 -1.1116 TD .0123 Tc [(vol)5.3(ume)-272.2(o)-.3(f)-276.7(t)5.3(he)-272.2(pr)5.5(ei)5.3(nocul)5.3(at)5.3(e,)-273.4(g)5.4(rown)-276.8(a)4.3(t)-276.9(3)5.4(2)]TJ /F8 1 Tf 16.5649 0 TD 0 Tc ()Tj /F6 1 Tf .4032 0 TD .0123 Tc [(C)-277.8(a)4.3(t)-276.9(2)5.4(00)-161.6(rp)5.4(m,)-273.4(and)]TJ -16.9681 -1.1116 TD .0097 Tc [(trea)-4.1(te)-4.1(d)-267.9(a)-4.1(s)-267.7(d)-2.9(escribe)-4.1(d)2.8(.)]TJ 1.0137 -1.1174 TD 0 Tc [(Cultivations)-252(were)-255.2(performed)-249.5(using)-253.1(capped)-252(and)-252.1(paralmed)]TJ -1.0137 -1.1116 TD [(culture)-269.4(vessels)-268.8(\(threaded)-272.7(screw)-267.7(caps)-265.7(for)-268.2(tubes;)-267(sterile)-269.4(rubber)]TJ T* [(plugs)-368.3(or)-370.8(aluminum)-369.8(foil)-367.5(for)-366.1(Erlenmeyer)-374.1(asks\).)-367.7(In)-365(compar-)]TJ T* [(ison,)-364.9(cultivations)-367.3(performed)-364.7(in)-359.4(loosely)-366(capped)-361.4(culture)-361.6(ves-)]TJ 0 -1.1174 TD [(sels)-385.4(yielded)-390.4(reliable)-387(growth,)-385.4(but)-383.6(irreproducible)-387.8(phenotypic)]TJ 0 -1.1116 TD [(measures,)-258.5(most)-247.5(likely)-255.8(due)-246.4(to)-250(evaporation)-257.7(of)-249.8(ethanol.)-249.9(Control)]TJ T* [(experiments)-310.6(included)-305.1(cultures)-304.9(conta)-8(ining)-299.5(all)-304.2(components)-308.3(of)]TJ 0 -1.1174 TD [(the)-701.5(medium)-701.5(except)-701.4(the)-701.5(bacterial)-706.1(inoculum)-702.6(\(inoculum-)]TJ 0 -1.1116 TD [(negative\))-290.1(or)-278.6(ethan)-8(ol)-278.8(carbon)-285.4(source)-285.2(\(ethanol-negative\);)-292.3(in)-278.8(all)]TJ T* [(cases,)-340.3(the)-332.9(controls)-338.3(yielded)-332.8(no)-336.3(growth.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 59.7543 338.2865 Tm [(2.3.)-502.8(Growth)-336.5(rates)-330.1(and)-335.7(plate)-336.2(counts)]TJ /F6 1 Tf 9.843 0 0 9.843 69.7323 321.8456 Tm [(Growth)-498(rates)-491.5(were)-497.1(determined)-494(by)-497.5(nonlinear)-490.5(regression)]TJ -1.0137 -1.1116 TD [(\(KaleidaGraph,)-577.3(Synergy)-567.4(Software;)-571.8(and)-563.2(Microsoft)-570.7(Excel\))]TJ T* [(using)-276.1(a)-267.2(modied)-275(version)-273.7(of)-267.1(the)-275.3(Gompertz)-272.5(equation)-276.3([Eq.)-267.1(\(1\)])]TJ 0 -1.1174 TD -.0159 Tc [(\()-15.9(B)9.7(egot)]TJ /F7 1 Tf 2.9432 0 TD -.0156 Tc [(et)-304.8(al.)]TJ /F6 1 Tf 1.9871 0 TD -.0158 Tc [(,)-301.5(1).4(9)-15.8(9)10.8(6\).)-301.5(R)-15.8(e)8.6(gres)-15.8(s)11.2(io)-15.8(n)-288.7(p).4(a)-15.8(r)9.7(amete)-15.8(r)9.7(s)-304.7(i).3(nclu)-15.8(d)10.8(e)-.8(d)-304.9(t).3(he)-306(time)]TJ -4.9303 -1.1116 TD -.015 Tc [(o)-15(f)-460.7(meas)-15(u)11.8(r)1.2(em)-15(e)9.2(n)1.2(t)-471.2(\()]TJ /F7 1 Tf 7.263 0 TD 0 Tc (t)Tj /F6 1 Tf .2649 0 TD -.016 Tc [(\),)-474.4(gr)-16(o)10.6(w)-.7(th)-477.9(rate)-479(\()]TJ /F7 1 Tf 6.4854 0 TD 0 Tc (k)Tj /F6 1 Tf .432 0 TD [(\))16.2(,)-458.4(la)25.3(g)-456.1(t)16.1(im)25.2(e)-457.3(\()]TJ /F7 1 Tf 5.2068 0 TD (L)Tj /F6 1 Tf .5414 0 TD -.016 Tc [(\),)-474.4(and)-477.9(t).1(he)]TJ -20.1935 -1.5033 TD -.0156 Tc [(ma)-15.6(x)9.8(i).5(mum)-259.8(l).5(og)]TJ ET 119.509 265.493 22.224 .39685 re f BT /F9 1 Tf 6.8899 0 0 6.8899 123.4771 266.7968 Tm 0 Tc (D)Tj /F7 1 Tf .6665 0 TD -.0268 Tc (OD)Tj /F9 1 Tf -1.2425 -1.0039 TD 0 Tc (D)Tj /F7 1 Tf .6665 0 TD -.0186 Tc (OD)Tj /F6 1 Tf 4.9215 0 0 4.9215 133.8519 258.8597 Tm -.0299 Tc (min)Tj /F13 1 Tf 9.843 0 0 9.843 113.6693 274.1102 Tm 2.2581 Tc ()Tj /F6 1 Tf 3.7035 -1.1059 TD -.0159 Tc [(value)-260.1(\()]TJ /F7 1 Tf 2.6725 0 TD 0 Tc (A)Tj /F6 1 Tf .599 0 TD [(\))16.2(.)-239.6(Fo)26.8(r)-237.2(t)16.1(he)-228(r)16.2(e)15(gr)26.6(e)15(s)16.4(si)26.7(o)16.2(n)16.2(s)0(,)-229(t)16.1(h)16.2(e)-238.4(n)26.8(a)15(l)]TJ -12.4525 -1.5033 TD -.016 Tc [(O)-16(D)-233.1(va)-16(l)9.3(u).2(es)-247.3(for)-247.4(the)-248.6(i).1(no)-16(c)9.4(u).2(lum)-16(-)9.4(nega)-16(t)9.3(i).1(ve)-248.6(cont)-16(r)10.5(o).2(ls)-247.3(wer)-16(e)-232.4(n)-16(e)9.4(glig)-16(i)10.5(b).2(le)-16(,)]TJ 0 -1.1116 TD 0 Tc [(th)26.5(e)15(r)16.2(e)15(b)0(y)-295.9(i)16.1(n)16.2(d)16.2(i)16.1(ca)24.3(t)16.1(i)16.1(n)0(g)-290.2(n)0(o)-290.2(m)15(ea)24.3(s)16.4(u)16.2(ra)25.5(b)16.2(l)16.1(e)-307.5(c)15(o)16.2(n)0(t)26.5(a)15(m)15(i)16.1(na)25.4(t)16.1(i)16.1(o)16.2(n)-306.4(o)16.2(r)-306.3(f)0(o)26.6(r)16.2(m)15(a)15(t)0(i)26.3(o)16.2(n)]TJ T* -.0158 Tc [(o)-15.8(f)-323.2(nonb)-15.8(i)10.7(o).4(lo)-15.8(g)10.8(i).3(cal)-333.8(p)-15.8(a)9.6(rti)-15.8(c)9.5(ulat)-15.8(e)-324.6(matte)-15.8(r)-324.4(a)-.8(fte)-15.8(r)-324.4(culti)-15.8(v)10.7(a)-.8(ti)-15.8(o)10.7(n).4(.)]TJ 1.5954 -2.9778 TD 0 Tc (log)Tj ET 1 i q 1 0 0 1 95.244 199.899 cm 0 0 m 10.488 0 l 10.488 -.397 l 0 -.397 l f* Q BT /F7 1 Tf 9.843 0 0 9.843 96.8882 203.9244 Tm (N)Tj -.167 -1.3651 TD (N)Tj /F6 1 Tf 6.8899 0 0 6.8899 101.7637 189.0141 Tm (0)Tj /F13 1 Tf 9.843 0 0 9.843 88.0441 211.1244 Tm 1.068 Tc ()Tj /F14 1 Tf 2.6955 -1.4111 TD 0 Tc ()Tj /F6 1 Tf 1.1001 0 TD (log)Tj ET 145.191 199.502 31.975 .39687 re f BT /F9 1 Tf 9.843 0 0 9.843 150.8598 203.9244 Tm (D)Tj /F7 1 Tf .6681 0 TD (OD)Tj /F9 1 Tf -1.2441 -1.3651 TD (D)Tj /F7 1 Tf .6681 0 TD (OD)Tj /F6 1 Tf 6.8899 0 0 6.8899 165.9401 189.0141 Tm (min)Tj /F13 1 Tf 9.843 0 0 9.843 138.0472 211.1244 Tm 3.2452 Tc ()Tj /F14 1 Tf -2.3845 -4.1931 TD 0 Tc ()Tj /F7 1 Tf .9331 0 TD (A)Tj /F14 1 Tf .8409 0 TD ()Tj /F6 1 Tf .4896 0 TD (exp)Tj /F14 1 Tf 2.0101 0 TD ()Tj /F6 1 Tf 1.1059 0 TD (exp)Tj ET 188.957 172.12 16.044 .39685 re f BT /F7 1 Tf 9.843 0 0 9.843 188.9574 176.5417 Tm (k)Tj /F14 1 Tf .6912 0 TD ()Tj /F7 1 Tf .4953 0 TD (e)Tj -.6796 -1.3651 TD (A)Tj /F14 1 Tf 1.3478 .6854 TD ()Tj /F7 1 Tf .8755 0 TD (L)Tj /F14 1 Tf .72 0 TD ()Tj /F7 1 Tf .9388 0 TD (t)Tj /F14 1 Tf -2.0389 .0058 TD 1.9534 Tc ()Tj 2.8914 -.0058 TD 0 Tc ()Tj /F6 1 Tf .9388 0 TD (1)Tj /F13 1 Tf -6.9059 1.4111 TD 6.678 Tc ()Tj -3.116 0 TD 10.5197 Tc ()Tj /F15 1 Tf 11.9802 -1.4111 TD 0 Tc (:)Tj /F6 1 Tf 1.8604 1.3938 TD (\(1\))Tj -22.1115 -3.9915 TD [(For)-296.9(all)-298.5(plate)-296.1(count)-294.8(measureme)-11(nts,)-294.7(aliquots)-298.2(were)-295.6(removed)]TJ -1.0137 -1.1174 TD [(from)-477.9(the)-476.9(cultures,)-475.4(decimally)-475.8(diluted)-475.8(in)-474.6(0.2)]TJ /F8 1 Tf 18.408 0 TD ()Tj /F6 1 Tf .72 0 TD [(M9)-475.4(\(by)-469.8(10)]TJ -19.128 -1.1116 TD [(100,000-fold\),)-423.3(and)-424.9(spread)-423.4(in)-417(20)]TJ /F9 1 Tf 13.4777 0 TD (m)Tj /F6 1 Tf .5529 0 TD [(L)-417(aliquots)-424.9(onto)-419.2(LB)-424.9(agar)]TJ -14.0306 -1.1116 TD [(plates.)-329.2(After)-330.1(incubation)-330.5(for)-325.8(1524)-172.5(h)-323.6(a)0(t)-326(3)0(2)]TJ /F8 1 Tf 16.9739 0 TD ()Tj /F6 1 Tf .3974 0 TD [(C,)-328.1(plates)-325.8(bearing)]TJ -17.3713 -1.1116 TD [(cl)13.8(ea)18.5(rl)20.7(y)-554(i)0(s)20.9(o)0(l)20.7(a)0(t)19.6(e)0(d)-544.8(c)0(o)13.9(l)0(o)20.7(n)0(i)20.7(e)0(s)19.9(,)-556.4(bu)20.8(t)-554.2(n)0(o)-543.6(m)0(o)19.6(r)0(e)-544.7(t)0(h)20.7(a)0(n)]TJ /F9 1 Tf 19.1107 0 TD (*)Tj /F6 1 Tf .9907 0 TD [(30)20.8(0,)-545.9(we)18.8(re)]TJ -20.1014 -1.1174 TD [(en)13.9(um)19.6(er)19.7(at)19.5(ed)-302.9(fr)20.9(om)-302.9(at)-303(le)19.6(as)14.1(t)-312.3(t)0(h)20.7(r)0(e)19.7(e)-313.3(bi)20.7(ol)14.9(og)20.8(ic)19.6(al)-303(re)19.7(pl)20.7(ic)19.6(at)13.8(es)19.9(,)-308.7(u)0(s)15.3(i)0(n)20.7(g)-312.1(at)]TJ 0 -1.1116 TD [(le)13.8(as)19.9(t)-248.9(t)0(w)19.8(o)-248.8(te)19.6(ch)19.7(ni)20.7(ca)18.5(l)-248.9(r)0(e)19.7(p)0(l)20.7(i)0(c)13.8(a)0(t)19.5(e)0(s)-239.3(p)0(e)19.7(r)-248.7(tr)20.7(ia)19.6(l.)-240.8(Fo)21(r)-248.7(t)0(h)20.7(i)0(s)-238.3(s)0(t)20.9(u)0(d)15.1(y)0(,)-234.9(L)0(B)-240.6(a)0(g)19.7(a)0(r)]TJ T* [(pl)14.9(at)19.5(es)-273.9(we)18.8(re)-274(us)15.3(ed)-274.1(fo)20.9(r)-283.3(r)0(e)19.7(p)0(r)20.9(o)0(d)15.1(u)0(c)19.7(i)0(b)20.7(i)0(l)20.6(i)0(t)20.6(y)-283.3(pu)15.1(rp)20.9(os)21(es)19.9(,)-285.7(a)0(s)-273.9(p)0(l)20.7(a)0(t)13.8(i)0(n)20.7(g)-283.3(on)20.8(to)]TJ 0 -1.1174 TD [(M9)19.9(/e)13.8(th)20.7(an)19.7(ol)-215.4(ag)13.9(ar)-216.4(pl)20.7(at)19.5(es)-222(pr)20.9(ov)20.8(id)20.7(ed)-222.2(un)20.8(re)19.7(li)20.6(ab)13.9(le)-216.6(ce)18.5(ll)-221.3(co)19.7(un)20.8(ts)-215.2(\(d)15.1(ue)-216.5(to)]TJ 25.5097 67.9242 TD [(in)20.7(co)19.7(ns)21(is)15.1(te)19.6(nt)-284.6(ad)19.7(so)21(rp)20.9(ti)20.6(on)-284.4(of)-284.4(et)19.5(ha)19.7(no)20.8(l)-295(o)0(n)20.8(t)0(o)-284.5(t)0(h)20.7(e)-296(ag)19.7(ar)-285.6(pl)20.7(at)19.6(es)-285.4(ac)18.5(ro)20.9(ss)]TJ 0 -1.1174 TD [(tr)20.7(ia)19.6(ls)20.9(,)-435.4(a)0(n)19.7(d)-427.3(lo)20.7(ss)-422.3(of)-422.6(et)19.5(ha)19.7(no)20.8(l)-433.2(a)0(n)19.7(d)-433.1(cr)19.7(ac)18.5(ki)20.7(ng)-422.7(of)-416.9(th)15(e)-428.5(a)0(g)19.7(a)0(r)-423.8(d)0(u)20.8(r)0(i)20.7(n)0(g)]TJ 0 -1.1116 TD [(in)20.7(cu)19.7(ba)19.7(ti)20.6(on)15.1(\).)-240.6(Ne)18.8(gl)20.7(ig)20.7(ib)20.7(le)-239.6(co)13.9(lo)20.7(ny)-238.3(co)19.7(un)20.8(ts)-244(we)18.8(re)-239.5(ob)20.8(ta)13.8(in)20.7(ed)-239.5(fr)20.9(om)-239.6(th)14.9(e)]TJ T* [(in)20.7(oc)19.7(ul)20.7(um)19.6(-n)15.1(eg)19.7(at)19.5(iv)20.7(e)-324.8(a)0(n)19.7(d)-323.6(et)19.5(ha)19.7(no)20.8(l-)15(ne)19.7(ga)19.7(ti)20.6(ve)-314.4(co)19.7(nt)20.7(ro)15.1(ls)20.9(.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 310.8472 670.3369 Tm [(2.4.)-496.4(Oxidative)-335.3(extremotolerance)-335.1(under)]TJ 0 -1.2203 TD [(ultraminimal)-337(conditions)]TJ /F6 1 Tf 9.843 0 0 9.843 320.8251 642.9542 Tm [(Cu)19.8(lt)20.6(ur)20.9(es)-308.4(\(4)15.1(0)-156.6(m)15(L\))-314.4(of)]TJ /F7 1 Tf 8.2825 0 TD [(A.)-305.2(ra)15.3(di)20.7(or)21(es)19.9(is)15.1(te)19.6(ns)]TJ /F6 1 Tf 7.0268 0 TD [(50)20.8(v1)-313.2(we)18.8(re)-308.6(pr)20.9(ep)19.7(ar)19.7(ed)]TJ -16.323 -1.1116 TD [(in)-342.1(ul)20.7(tr)20.7(am)18.5(in)20.7(im)19.5(al)-343.3(me)18.4(di)20.7(um)-343.3(\(0)20.9(.2)]TJ /F8 1 Tf 11.865 0 TD ()Tj /F6 1 Tf .7084 0 TD [(M9)19.9(,)-349(2)0(6)]TJ /F9 1 Tf 3.1102 0 TD (m)Tj /F6 1 Tf .5472 0 TD .3476 Tc [(MF)347.6(e)]TJ 7.3823 0 0 6.5614 492.3778 636.3778 Tm 0 Tc (2)Tj /F8 1 Tf .4915 0 TD (+)Tj /F6 1 Tf 9.843 0 0 9.843 499.9747 632.0125 Tm [(\),)-344.3(co)19.7(nt)20.7(ai)19.6(ni)20.7(ng)]TJ -19.2144 -1.1174 TD [(16)-146.2(mM)-217.4(et)19.5(ha)19.7(no)20.8(l)-231.6(\()0(0)20.9(.)13.9(1%)-222.1(v/)20.7(v\))20.9(,)-228.1(a)0(n)19.7(d)-225.7(ex)19.7(po)20.8(se)14.1(d)-225.7(t)0(o)-215.4(h)0(y)20.8(d)0(r)20.9(o)0(g)15.1(e)0(n)-216.5(p)0(e)19.7(r)0(o)20.9(x)0(i)20.7(d)0(e)]TJ 0 -1.1116 TD (\(H)Tj 7.3823 0 0 6.5614 320.9952 608.4282 Tm (2)Tj 9.843 0 0 9.843 324.5668 610.0723 Tm (O)Tj 7.3823 0 0 6.5614 331.5968 608.4282 Tm (2)Tj 9.843 0 0 9.843 335.1684 610.0723 Tm [(\).)-286.7(As)-285.1(nu)20.8(tr)20.7(ie)19.6(nt)14.9(-r)20.9(ic)19.5(h)-294.8(c)0(o)19.7(n)0(t)20.7(r)0(o)20.9(l)0(s)15.1(,)-291.4(cu)19.7(lt)14.8(ur)20.9(es)-285.4(\(4)20.9(0)-156.6(m)0(L)18.4(\))-294.8(we)18.8(re)-285.6(al)19.5(so)]TJ -2.4709 -1.1116 TD [(pr)20.9(ep)19.7(ar)19.7(ed)-210.7(in)-209.7(LB)-211.8(an)19.7(d)-220(e)0(x)19.7(p)0(o)20.8(s)0(e)19.9(d)-220(to)-209.7(H)]TJ 7.3823 0 0 6.5614 438.066 597.4865 Tm (2)Tj 9.843 0 0 9.843 441.6944 599.1306 Tm (O)Tj 7.3823 0 0 6.5614 448.6676 597.4865 Tm (2)Tj 9.843 0 0 9.843 452.2393 599.1306 Tm [(.)-222.3(A)0(l)19.8(l)-220.1(cu)19.7(lt)20.6(ur)20.9(es)-210.5(we)18.8(re)-210.7(gr)20.9(ow)14.2(n)]TJ -14.3647 -1.1174 TD [(to)-169.4(mi)19.5(d-)15.1(lo)20.7(g)-179.6(p)0(h)20.8(a)0(s)14.1(e)-180.8(\()]TJ /F9 1 Tf 6.998 0 TD (*)Tj /F6 1 Tf .9907 0 TD (2)Tj /F8 1 Tf .6566 0 TD ()Tj /F6 1 Tf .7084 0 TD (10)Tj 7.3823 0 0 6.5614 412.5542 592.5542 Tm (8)Tj 9.843 0 0 9.843 418.0534 588.1321 Tm [(cf)14(u/)20.7(mL)-171.7(in)-175.1(0.)24.3(2)]TJ /F8 1 Tf 5.4314 0 TD ()Tj /F6 1 Tf .7142 0 TD [(M9)19.9(;)]TJ /F9 1 Tf 1.8258 0 TD (*)Tj /F6 1 Tf .9907 0 TD (2)Tj /F8 1 Tf .6566 0 TD ()Tj /F6 1 Tf .7084 0 TD (10)Tj 7.3823 0 0 6.5614 529.3416 592.5542 Tm (9)Tj 9.843 0 0 9.843 534.8408 588.1321 Tm [(cf)19.7(u/)]TJ -22.7566 -1.1116 TD [(mL)-212(in)-215.4(LB)18.6(\),)-211.8(as)19.9(ep)19.7(ti)20.6(ca)18.5(ll)14.8(y)-220(d)0(i)20.7(v)0(i)20.7(d)0(e)13.9(d)-220(in)20.7(to)-215.4(eq)19.7(ua)19.7(l)-220.1(p)0(o)15.1(r)0(t)20.7(i)0(o)20.7(n)0(s)21(,)-222.3(tr)15(an)19.7(sf)21.1(er)19.7(re)19.7(d)]TJ T* .0133 Tc [(t)6.3(o)-304.6(2)6.4(5).7(0)-166.3(m)5.2(L)-300(E)-.5(rl)6.3(en)6.4(me)5.3(ye)5.3(r)-304.5()6.6(ask)6.4(s).9(,)-301.2(a)5.3(nd)-304.6(t)6.3(r).7(e)5.3(a)-.5(t)6.3(e)-.5(d)-304.6(s)6.6(ep)6.4(ar)6.5(at)6.3(ely)-298.8(a)-.5(s)-298.6(t).6(h)6.4(e)]TJ T* .0131 Tc [(r)6.3(e)-.7(sp)6.2(ec)5.1(ti)6.1(ve)-265.6(ex)6.2(po)6.2(sed)-264.5(a)-.7(n)6.2(d)-270.2(u)6.2(n).5(e)5.1(x).5(p)6.2(o).5(se)5.1(d)-264.5(s).7(am)5(pl)6.1(es)6.4(.)]TJ 1.0137 -1.1174 TD [(T)5(o)-276.1(th)6.1(e)-283(e)5(xp)6.1(os)6.3(ed)-276.1(sa)5(mp)6.1(le)5(s,)-278.4(n)6.1(al)-276.2(c)5(o).4(n)6.1(cen)6.1(tr)6.2(at)6(io)6.1(ns)-275.9(of)-276.1(10)6.1(,)-278.4(1).4(0)6.1(0).4(,)]TJ -1.0137 -1.1116 TD .0113 Tc [(and)-387.2(4)4.4(00)-162.6(mM)-388.1(\()4.5(0)-1.3(.03)4.4(4)-1.3(%,)-389.5(0)4.4(.)2.1(34%,)-389.5(a)3.3(nd)-387.2(1)4.4(.)2.1(4%)-388.3(w/v)4.4(\))-387.2(H)]TJ 7.3823 0 0 6.5614 511.8802 531.7227 Tm 0 Tc (2)Tj 9.843 0 0 9.843 515.6786 533.3668 Tm (O)Tj 7.3823 0 0 6.5614 522.8219 531.7227 Tm (2)Tj 9.843 0 0 9.843 530.4754 533.3668 Tm .0073 Tc [(we)-6.5(re)]TJ -22.3131 -1.1116 TD .0072 Tc [(ad)-5.4(de)-6.6(d)-471.9(\().4(n)-5.4(o).3(n)-5.4(s)-5.2(ta)-6.6(bi)-5.5(li)-5.5(z)-6.6(e)-.8(d)-471.9(3).3(0)-5.4(%)-473(w/)-5.5(w;)-472.1(S)-5.3(i).2(g)-5.4(m)-.9(a)-6.6(-).4(A)-6.3(l)-5.5(dr)-5.4(ic)-6.6(h\))-5.4(,)-468.5(a)-6.6(nd)-472(i)-5.5(n).3(-)]TJ 0 -1.1174 TD .0135 Tc [(c)5.5(u).9(b)6.6(a)-.3(t)6.5(e)-.3(d)-344.7(i)6.5(n)-344.7(p)6.6(ar)6.7(al)6.5(lel)-339.1(f).9(o)6.6(r)-344.7(1)-160.4(h)-344.7(at)-339.1(32)]TJ /F8 1 Tf 13.3222 0 TD 0 Tc ()Tj /F6 1 Tf .4089 0 TD .007 Tc [(C)-346.5(w)-6.5(it)-5.7(h)-345.4(c)-6.8(o)-5.6(n).1(s)-5.4(t)0(a)-6.8(n).1(t)-351.3(a)-6.8(gi)-5.7(ta)-6.8(ti)-5.7(on)]TJ -13.7311 -1.1116 TD 0 Tc [(at)-464.3(20)20.8(0)-156.6(r)0(p)20.9(m)0(.)-460.8(U)0(p)20(o)0(n)-463(c)0(o)19.7(m)0(p)19.6(l)0(e)19.5(t)0(i)14.8(o)0(n)20.8(,)-470(10)20.8(0)]TJ /F9 1 Tf 14.5721 0 TD (m)Tj /F6 1 Tf .5414 0 TD [(L)-474.6(o)0(f)-462.9(t)0(h)20.7(e)-474.6(cu)19.7(lt)20.6(ur)20.9(es)-464(wa)18.8(s)]TJ -15.1135 -1.1116 TD [(qu)20.8(en)19.7(ch)19.7(ed)-354.7(1:)14.9(10)-353.5(wi)19.8(th)-353.7(0.)18.5(1)-156.6(m)0(g)19.6(/)0(m)19.5(L)-365.2(bo)20.8(vi)20.7(ne)-360.5(li)20.6(ve)19.7(r)-363.9(c)0(a)18.5(t)0(a)19.6(l)0(a)13.8(s)0(e)-354.5(\()0(t)20.7(o)-364(re)19.7(-)]TJ 0 -1.1174 TD [(mo)19.6(ve)-222.2(an)19.7(y)-237.2(e)0(x)19.7(c)0(e)18.5(s)0(s)-226.4(H)]TJ 7.3823 0 0 6.5614 385.6818 476.9574 Tm (2)Tj 9.843 0 0 9.843 389.3101 478.5447 Tm (O)Tj 7.3823 0 0 6.5614 396.2834 476.9574 Tm (2)Tj 9.843 0 0 9.843 399.855 478.5447 Tm [(\).)-223.4(Th)19.6(e)-238.4(e)0(x)19.7(p)0(o)20.8(s)0(e)19.9(d)-237.2(an)19.7(d)-237.2(u)0(n)20.8(e)0(x)19.7(p)0(o)20.8(s)0(e)19.9(d)-237.2(cu)19.7(lt)20.6(ur)20.9(es)]TJ -9.0427 -1.1116 TD .0072 Tc [(we)-6.6(re)-444.3(th)-5.4(en)-437.4(d)-5.4(e)-.8(c)-6.6(i).2(m)-6.6(a)-.8(l)-5.5(l)-5.5(y)-437.4(di)-5.5(lu)-5.4(te)-6.6(d)-437.4(\()-5.4(10)]TJ 7.3823 0 0 6.5614 446.5132 471.9684 Tm 0 Tc (4)Tj 9.843 0 0 9.843 450.3117 467.603 Tm .4446 Tc [(-a)430.8(n)437.7(d)0(1)432(0)]TJ 7.3823 0 0 6.5614 486.8219 471.9684 Tm 0 Tc (5)Tj 9.843 0 0 9.843 490.6203 467.603 Tm .0127 Tc [(-fo)5.8(ld)-431.9(d)5.8(ilu)5.8(ti)5.7(on)5.8(s)]TJ -18.264 -1.1116 TD .0069 Tc [(fo)-5.7(r)-276.4(t)-5.8(he)-277.6(0)-5.7(.)-2.3(2)]TJ /F8 1 Tf 4.4465 0 TD 0 Tc ()Tj /F6 1 Tf .7315 0 TD .0071 Tc [(M)-6.4(9)-276.2(sa)-6.7(mp)-5.5(le)-6.7(s,)-278.6(a)-6.7(n).2(d)-276.2(1)-5.5(0)]TJ 7.3823 0 0 6.5614 443.3384 461.0267 Tm 0 Tc (6)Tj 9.843 0 0 9.843 447.1369 456.6613 Tm .0127 Tc [(-fo)5.8(ld)-270.6(d)5.8(ilu)5.8(ti)5.7(on)5.8(s)-276.2(f)5.9(or)-270.6(t)5.7(h).1(e)-271.8(L)-1.1(B)]TJ -13.8463 -1.1116 TD .0072 Tc [(sa)-6.6(mp)-5.4(le)-6.6(s)-5.2(\)).4(,)-405.2(a)-6.6(nd)-408.6(1)-5.4(0).3(0)]TJ /F9 1 Tf 7.885 0 TD 0 Tc (m)Tj /F6 1 Tf .5587 0 TD .0118 Tc [(L)-405.2(a)3.8(li)4.8(qu)4.9(ots)-398(w)-1.7(ere)-399.4(s)-.6(pr)5(ead)-404(o)4.9(nt)4.8(o)-404(L)3.7(B)-405(a)3.8(gar)]TJ -8.4437 -1.1174 TD .0088 Tc [(plate)-5(s)2.1(.)-271.1(P)-3.7(la)-5(te)-5(s)-268.6(w)-4.7(ere)-269.9(i)-3.9(nc)-5(ubated)]TJ 12.1818 0 TD .0113 Tc [(and)-266.3(e)3.3(numerat)4.3(ed)-266.3(as)-271.8(d)4.4(e)-2.5(scri)4.3(bed.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 310.8472 412.8377 Tm 0 Tc [(2.5.)-496.4(Alcohol)-339.8(dehydrogenase)-329.9(kinetics)]TJ /F6 1 Tf 9.843 0 0 9.843 320.8251 396.3968 Tm [(The)-282.1(kinetics)-287.8(of)-290.2(alcohol)-286.8(dehydrogenase)-289.5(were)-289.8(measured)-289.8(by)]TJ -1.0137 -1.1174 TD [(absorbance)-384.1(spectroscopy)-379.3(\(Beckman)-383.2(Coulter)-384.5(DU640\).)-380.4(Mid-)]TJ 0 -1.1116 TD [(log)-377.8(phase)-376.3(cultures)-379.8(\(80)-164.5(mL\))-380.1(of)]TJ /F7 1 Tf 12.6829 0 TD [(A.)-374.4(radioresistens)]TJ /F6 1 Tf 7.2803 0 TD [(50v1)-378.8(were)]TJ -19.9631 -1.1116 TD [(prepared)-369.3(in)-365.2(0.2)]TJ /F8 1 Tf 6.4394 0 TD ()Tj /F6 1 Tf .72 0 TD [(M9)-366(\(with)-369.5(26)]TJ /F9 1 Tf 5.3968 0 TD (m)Tj /F6 1 Tf .5529 0 TD .3649 Tc [(MF)364.9(e)]TJ 7.3823 0 0 6.5614 462.0471 367.8802 Tm 0 Tc (2)Tj /F8 1 Tf .4992 0 TD (+)Tj /F6 1 Tf 9.843 0 0 9.843 469.814 363.5149 Tm [(\))-369.7(containing)-365.1(16)-169.2(mM)]TJ -16.1502 -1.1174 TD [(ethanol.)-457.2(Cells)-462.8(were)-456.8(harvested)-462.6(by)-457.2(centrifugation)-457.1(at)-458.5(6000)]TJ /F7 1 Tf 23.7876 0 TD (g)Tj /F6 1 Tf -23.7876 -1.1116 TD [(at)-447(4)]TJ /F8 1 Tf 1.6761 0 TD ()Tj /F6 1 Tf .3974 0 TD [(C)-451.4(for)-446.7(10)-169.2(min)-448.2(\(Beckman)-452.3(Coulter)-453.6(Allegra)]TJ /F8 1 Tf 16.9566 0 TD ()Tj /F6 1 Tf 1.3305 0 TD [(21R\),)-452.3(the)]TJ -20.3606 -1.1116 TD [(supernatants)-558(were)-554.7(discarded,)-552.4(and)-551.6(cell)-554.2(pellets)-557.4(thoroughly)]TJ T* [(washed)-343.7(by)-336.3(resuspending)-343.6(in)-342.1(20)-163.5(mL)-344.4(1)]TJ /F8 1 Tf 14.8255 0 TD ()Tj /F6 1 Tf .887 0 TD [(PBS,)-341.5(harvesting,)-345.1(and)]TJ -15.7125 -1.1174 TD [(repeating)-411(the)-407.8(procedure)-410.8(another)-407.6(two)-413.2(times;)-406.6(at)-406.7(the)-413.5(penulti-)]TJ 0 -1.1116 TD [(mate)-336.4(step,)-337.2(samples)-333.6(were)-341.6(aliquoted)-335.2(and)-332.8(the)-338.7(nal)-333.8(cell)-335.3(pellets)]TJ T* [(stored)-336(at)]TJ /F8 1 Tf 3.8417 0 TD (-)Tj /F6 1 Tf .5529 0 TD (80)Tj /F8 1 Tf 1.0022 0 TD ()Tj /F6 1 Tf .3917 0 TD (C.)Tj -4.7748 -1.1174 TD [(Protein)-331.5(extracts)-340.6(were)-335.9(prepared)-334.8(from)-333.9(0.10.2)-167.9(g)-329.4(o)0(f)-336.2(the)-332.9(cell)]TJ -1.0137 -1.1116 TD [(pellets)-332.8(\(wet)-329.1(mass\),)-333.5(which)-330.2(were)-330.1(thawed)-332.5(on)-330.5(ice,)-331.7(resuspended)]TJ T* [(in)-301.8(10)-146.2(mL)-309.9(50)-146.2(mM)-303.8(HE)18.8(PE)19.8(S)-312(b)0(u)15.1(f)0(f)20.9(e)0(r)-302.8(\()0(p)15.1(H)-313(7.)18.5(5\))20.9(,)-314.5(a)0(n)19.7(d)-312.1(ul)20.7(tr)15(as)19.9(on)20.8(ic)19.6(at)19.5(ed)]TJ 0 -1.1174 TD [(at)-228.1(30)-146.2(s)-237.1(i)0(n)20.7(t)0(e)19.6(r)0(v)20.9(a)0(l)19.5(s)-237(\(w)14.2(it)20.6(h)-237.2(3)0(0)-146.2(s)-237(in)20.7(te)19.6(rv)20.9(al)19.6(s)-237(o)0(n)-226.8(i)0(c)19.5(e)0(\))-228(f)0(o)15.1(r)-231.5(a)-238.4(t)0(o)20.7(t)0(a)13.8(l)-231.6(of)-226.8(2)-156.6(m)0(i)19.5(n)]TJ 0 -1.1116 TD [(of)-261.4(ul)20.7(tr)20.7(as)19.9(on)20.8(ic)13.8(at)19.5(io)20.7(n)-271.8(a)0(t)-256.9(a)-273(po)20.8(we)18.8(r)-271.8(o)0(f)-261.4(5)-266(\(V)20(ir)15(ti)20.6(s)-271.6(V)0(i)19.8(r)0(s)21.1(o)0(n)20.8(i)0(c)-262.7(S)0(o)21(n)0(i)20.7(c)0(a)18.5(t)0(o)14.9(r)0(\))20.9(.)]TJ T* [(Th)19.6(e)-232.6(s)0(u)21(s)0(p)21(e)0(n)13.9(s)0(i)20.9(o)0(n)20.8(s)-231.3(we)18.8(re)-222.2(th)15(en)-222.2(ce)18.5(nt)20.7(ri)20.7(fu)20.9(ge)13.9(d)-231.5(a)0(t)-222.4(6)0(0)20.8(0)0(0)]TJ /F7 1 Tf 18.5405 0 TD (g)Tj /F6 1 Tf .7315 0 TD [(fo)20.9(r)-231.4(2)0(0)-146.2(m)0(i)19.5(n)-231.5(at)]TJ -19.272 -1.1174 TD (4)Tj /F8 1 Tf .4896 0 TD ()Tj /F6 1 Tf .3859 0 TD [(C,)-408.7(th)20.7(e)-417(s)0(u)15.3(p)0(e)19.7(r)0(n)20.9(a)0(t)19.5(a)0(n)19.7(t)0(s)-411.1(a)0(n)19.7(d)-415.8(pe)13.9(ll)20.6(et)19.6(s)-415.6(s)0(a)14.1(v)0(e)19.7(d)0(,)-407.7(a)0(n)19.7(d)-415.8(in)15(de)19.7(pe)19.7(nd)20.8(en)19.7(tl)20.6(y)]TJ -.8755 -1.1116 TD [(an)19.7(al)19.5(yz)19.7(ed)-418.1(fo)15.1(r)-427.3(a)0(l)19.5(c)0(o)19.7(h)0(o)20.8(l)-433.2(de)19.7(hy)20.8(dr)20.9(og)20.8(en)13.9(as)19.9(e)-428.5(a)0(c)18.5(t)0(i)20.6(v)0(i)20.7(t)0(y)14.9(.)-423.9(Pe)14.1(ll)20.6(et)19.5(ed)-418.1(sa)19.9(m-)]TJ T* [(pl)20.7(es)-285.4(we)18.8(re)-285.6(re)19.7(su)15.3(sp)21(en)19.7(de)19.7(d)-294.8(i)0(n)-284.5(5)0(0)20.8(0)]TJ /F9 1 Tf 11.9341 0 TD (m)Tj /F6 1 Tf .5414 0 TD .2958 Tc [(Lo)295.8(f)11.4(5)295.8(0)143.9(m)310.8(MH)295.8(E)314.6(P)295.8(E)315.6(S)1.1(\()295.8(p)310.9(H7)295.8(.)320.1(5)295.8(\))]TJ -12.4755 -1.1116 TD 0 Tc [(co)19.7(nt)20.7(ai)19.5(ni)20.7(ng)-359.3(1%)-360.4(Tr)19.7(it)20.6(on)-359.3(X-)14.2(10)20.8(0)-369.7(\()0(v)20.9(/)0(v)20.7(\))0(.)-361.6(A)0(l)19.8(l)-369.9(sa)19.9(mp)19.6(le)19.5(s)-369.5(w)0(e)18.8(r)0(e)-360.4(s)0(t)20.9(o)0(r)20.9(e)0(d)]TJ 0 -1.1174 TD [(on)-313.2(ic)19.5(e)-324.8(a)0(n)19.7(d)-323.6(im)19.5(me)18.4(di)20.7(at)19.5(el)19.5(y)-323.6(a)0(n)19.7(a)0(l)13.8(y)0(z)19.7(e)0(d)19.7(.)]TJ 1.0137 -1.1116 TD [(As)-377.3(de)19.7(te)19.6(rm)19.6(in)20.7(ed)-383.5(in)-376.7(co)19.7(nt)20.7(ro)15.1(l)-387.1(e)0(x)19.7(p)0(e)19.7(r)0(i)15(m)15(e)0(n)13.9(t)0(s)20.9(,)-389.3(re)19.7(pr)20.9(od)20.8(uc)19.7(ib)15(le)-377.9(ra)19.7(te)19.6(s)]TJ -1.0137 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[(SURVIVAL)-340.1(ON)-334.6(SPACECRAFT)-335.2(CLEANING)-337.5(REAGENTS)-28647.3(3)]TJ ET endstream endobj 59 0 obj <>stream hL_HSas>Z۰h?С DڅH2psLinY+(oJKIP t#QAze"߳4%' AER]y3];Q^qϺm-{Z(ؗZ8iDtqoYs_X.DA4/qByqC0ªX/NZZJ2:jɖ10 h b3dTUȩ 0>4Hk7a\#2F_81DtvT$?#=M pu"wbX<:<60oZߣs1&MXЏ͔162"G>stream HAKFDO+AdvP4C4E51 l AdvP4C4E51#[j-e~~vVE=0c4:# jtqurf><$R?6sprsoxiiy endstream endobj 64 0 obj <>stream hTPMk0 WرBrK׻k+agYKz'=ޓ=d/v%85KPV`kQʃn-Z8/9o O6Ȗ؜ʟs$_4`rd=ܗ38y V57@2ϳťWY]#&U:@1\8GH|J%cHiV endstream endobj 67 0 obj <>stream /GS1 gs BT /F6 1 Tf 9.843 0 0 9.843 62.022 725.1588 Tm 0 0 0 rg 0 Tc 0 Tw [(Al)19.8(l)-254.7(r)0(e)19.7(a)0(c)18.5(t)0(i)20.6(o)0(n)20.8(s)-254.3(we)18.8(re)-245.2(th)20.7(or)20.9(ou)20.8(gh)20.8(ly)-244.2(bu)20.8(t)-254.7(g)0(e)19.7(n)0(t)20.7(l)0(y)-238.5(m)0(i)19.5(x)0(e)13.9(d)0(,)-240.7(1)-156.6(mL)-240.8(in)-244.2(n)21(al)]TJ 0 -1.1174 TD 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[(\).)-338.6(Fo)21(r)-352.4(c)0(o)19.7(n)0(t)20.7(r)0(o)15.1(l)-346.8(pu)15.1(r-)]TJ -16.8817 -1.1116 TD [(po)20.8(se)14.1(s,)-315.4(ra)19.7(te)19.6(s)-329.2(o)0(f)-313.2(b)0(a)19.7(c)0(k)13.9(g)0(r)20.9(o)0(u)20.8(n)0(d)-319(r)0(e)19.7(d)0(u)20.8(c)0(t)19.5(i)0(o)20.7(n)-329.4(of)-313.2(XT)13(T)-324.8(b)0(y)-319(t)0(h)20.7(e)-324.8(ce)18.5(ll)20.6(ul)14.9(ar)]TJ T* [(ex)19.7(tr)20.7(ac)12.8(ts)20.9(,)-256.9(i)0(n)-250(t)0(h)15(e)-261.4(ab)19.7(se)19.9(nc)19.7(e)-261.4(o)0(f)-249.8(s)0(u)21(b)0(s)15.3(t)0(r)20.7(a)0(t)19.5(e)0(,)-253.4(w)0(e)18.8(r)0(e)-251(a)0(l)19.5(s)0(o)-249.7(m)0(e)18.4(a)0(s)19.9(u)0(r)15.1(e)0(d)19.7(.)]TJ 1.0137 -1.1174 TD .0201 Tc [(Spe)-5.2(c).6(ic)-437.2(a)-5.2(ctivities)-441.6(we)-5.2(re)-442.9(expr)]TJ 12.4179 0 TD .019 Tc [(es)-4.9(sed)-442.9(a)-.5(s)-442.7(p)-5.1(kat)-5.3(/).5(mg)-442.9(pr)-5.1(otei)-5.3(n)]TJ -13.4316 -1.1116 TD 0 Tc [(\(1)-307.4(pk)20.8(at)]TJ /F8 1 Tf 2.995 0 TD (=)Tj /F6 1 Tf .7084 0 TD (1)Tj /F8 1 Tf .6566 0 TD ()Tj /F6 1 Tf .7084 0 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[(sa)19.9(ys)-485.8(fo)20.9(ll)20.6(ow)20(in)20.7(g)-496.4(t)0(h)20.7(e)-491.8(ma)18.4(nu)20.8(fa)19.7(ct)19.5(ur)20.9(er)14(s)-480(in)20.7(st)20.9(ru)15.1(ct)19.5(io)20.7(ns)21(.)-493(M)0(i)19.8(c)0(h)19.7(a)0(e)18.5(l)0(i)14.8(s)0()]TJ T* [(Me)18.8(nt)20.7(en)-297.1(ps)21(eu)19.7(do)20.8(pa)19.7(ra)14(m)15(e)0(t)13.8(e)0(r)19.7(s)-300.4(we)18.8(re)-291.3(ca)12.8(lc)19.6(ul)20.7(at)19.5(ed)-291.3(th)20.7(ro)15.1(ug)20.8(h)-300.6(n)0(o)20.8(n)0(l)20.7(i)0(n)15(e)0(a)18.5(r)]TJ T* [(le)19.5(as)19.9(t-)15(sq)21(ua)19.7(re)19.7(s)-409.8()0(t)20.9(t)0(i)20.6(n)0(g)-399.6(o)0(f)-393.8(t)0(h)20.7(e)-405.4(ra)14(te)-395.1(da)19.7(ta)-395.1(\(I)15.1(C)]TJ 7.3823 0 0 6.5614 222.5196 570.1038 Tm -.0162 Tc (50)Tj 9.843 0 0 9.843 233.8015 571.7479 Tm 0 Tc [(To)19.6(ol)20.7(ki)20.7(t;)-399.9(ic)19.6(50)20.8(.t)18.4(k\))20.9(,)]TJ -17.4519 -1.1174 TD [(wh)20(ic)19.5(h)-300.6(p)0(r)20.9(o)0(v)20.8(i)0(d)20.7(e)0(d)-291.3(t)0(h)20.7(e)-296(pa)19.7(ra)19.7(me)18.4(te)19.6(rs)-290(of)-284.4(ma)18.4(xi)20.7(mu)19.6(m)-296.1(s)0(p)15.3(e)0(c)18.5(i)0()20.9(c)-296(ac)18.5(ti)20.6(vi)14.9(ty)]TJ 0 -1.1116 TD .0072 Tc [(o)-5.4(f)-431.6(ca)-6.6(ta)-6.6(ly)-5.4(si)-5.5(s)-431.4(\()-5.4(pk)-5.4(at)-5.5(/m)-6.6(g\))-431.6(a)-6.6(n).3(d)]TJ /F7 1 Tf 11.6404 0 TD .0128 Tc [(ap)5.9(pa)5.9(ren)5.9(t)-426.2(K)]TJ /F6 1 Tf 7.3823 0 0 6.5614 223.8235 548.1636 Tm 0 Tc (M)Tj 9.843 0 0 9.843 234.7086 549.8077 Tm .0131 Tc [(\(m)5(M\))6.3(;)-425.9().7(t)6.1(s)-425.5(we)5.1(re)]TJ -17.5441 -1.1116 TD .0121 Tc [(ob)5.2(tain)5.2(ed)-253.9(usi)5.1(n)-.5(g)-253.9(a)-1.7(g)5.2(g)-.5(r)5.3(e)-1.7(gated)-259.7(d)5.2(at)5.1(a)-260.9(f)5.3(ro)5.2(m)-260.9(s)5.4(ev)5.2(eral)-254.1(tri)5.1(a)-1.7(l)5.1(s)-259.5(\()]TJ /F7 1 Tf 21.1036 0 TD 0 Tc (n)Tj /F8 1 Tf .6796 0 TD (=)Tj /F6 1 Tf .7315 0 TD .0069 Tc [(7)-5.7(9,)]TJ -22.5147 -1.1174 TD .0124 Tc [(et)5.4(hano)5.5(l;)]TJ /F7 1 Tf 3.7092 0 TD 0 Tc (n)Tj /F8 1 Tf .6739 0 TD (=)Tj /F6 1 Tf .7315 0 TD .0072 Tc [(3)-5.4(7,)-393.6(2-)-5.4(pr)-5.4(o)-5.4(p).3(a)-6.6(n).3(o)-5.4(l).2(\))-5.4(,)-387.9(a)-6.6(n).3(d)-391.3(s)-5.2(ta)-6.6(nd)-5.4(ar)-5.4(d)-391.3(d).3(e)-6.6(v).3(i)-5.5(a)-.8(t)-5.5(i).2(o)-5.4(n)-391.3(wa)-6.6(s)]TJ -5.1146 -1.1116 TD .0132 Tc [(ca)5.2(lc)5.2(ul)6.2(at)6.2(ed)-327.7(fro)6.3(m)-328.9(t).5(h)6.3(e)-334.6(s)6.5(t).5(an)6.3(da)]TJ 11.0529 0 TD .0122 Tc [(rd)-328.7(er)5.4(ro)5.3(r)-334.4(o)5.3(f)-334.4(t)5.2(he)-329.9(regress)5.5(ion)5.3(.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 62.022 489.4865 Tm 0 Tc [(2.6.)-502.8(Stable)-334.1(isotope)-333.8(labeling)-335.5(and)-329.4(metabolite)-340.9(proling)]TJ /F6 1 Tf 9.843 0 0 9.843 72 473.0456 Tm [(St)20.9(at)19.5(io)20.7(na)13.9(ry)-278.6(ph)20.8(as)19.9(e)-290.2(c)0(u)19.7(l)0(t)20.6(u)0(r)20.9(e)0(s)-279.6(\()0(2)-151.9(m)0(L)18.4(\))-283.3(of)]TJ /F7 1 Tf 14.3417 0 TD [(A.)-276.4(ra)21(di)20.7(or)15.3(es)19.9(is)20.9(te)19.6(ns)]TJ /F6 1 Tf 6.9692 0 TD [(50)20.8(v1)]TJ -22.3246 -1.1116 TD [(\(O)20(D)]TJ /F9 1 Tf 2.206 0 TD (*)Tj /F6 1 Tf .9907 0 TD [(0.)18.5(9,)]TJ /F9 1 Tf 1.9237 0 TD (*)Tj /F6 1 Tf .9907 0 TD (9)Tj /F8 1 Tf .6566 0 TD ()Tj /F6 1 Tf .7084 0 TD (10)Tj 7.3823 0 0 6.5614 145.3039 466.4692 Tm (8)Tj 9.843 0 0 9.843 153.4677 462.1038 Tm -.0185 Tc [(c)-18.5(f)1.2(u)-18.5(/)2.2(m)-18.5(L)-.1(\))-474.6(w)-18.5(er)-18.5(e)-465.3(p)-18.5(re)-18.5(pa)-18.5(re)-18.5(d)-465.4(a)-18.5(s)-465.2(d)-18.5(es)-18.5(cr)-18.5(ib)-18.5(ed)]TJ -9.2904 -1.1174 TD 0 Tc [(us)21(in)15(g)-410(e)0(t)19.5(h)0(a)13.9(n)0(o)20.8(l)-410.2(\(n)15.1(at)19.5(ur)20.9(al)-406.7(ab)19.7(un)20.8(da)19.7(nc)19.7(e\))-406.5(or)]TJ 7.3823 0 0 6.5614 214.696 455.4707 Tm (13)Tj 9.843 0 0 9.843 221.896 451.1054 Tm (C)Tj 7.3823 0 0 6.5614 228.359 449.4613 Tm [(1,)20.4(2)]TJ 9.843 0 0 9.843 237.3165 451.1054 Tm [(-l)20.7(ab)19.7(el)13.8(ed)-400.8(et)19.5(ha)13.9(no)20.8(l)]TJ -17.809 -1.1116 TD -.0202 Tc [(u)-20.2(n).6(d)-20.2(e)-.5(r)-470.5(u)-20.2(lt)-20.2(ra)-20.2(mi)-20.2(ni)-20.2(ma)-20.2(l)-461.4(c)-20.2(on)-20.2(di)-20.2(ti)-20.2(o)-5.2(n)-20.2(s)-454.2(\()-20.2(0.)-20.2(2)]TJ /F8 1 Tf 14.4684 0 TD 0 Tc ()Tj /F6 1 Tf .7084 0 TD [(M9)19.9(,)-446.9(2)0(6)]TJ /F9 1 Tf 3.2082 0 TD (m)Tj /F6 1 Tf .5414 0 TD .4513 Tc [(MF)451.3(e)]TJ 7.3823 0 0 6.5614 271.1054 444.529 Tm 0 Tc (2)Tj /F8 1 Tf .4838 0 TD (+)Tj /F6 1 Tf 9.843 0 0 9.843 278.7023 440.1636 Tm [(\).)-436.5(Al)19.8(l)]TJ -22.0136 -1.1116 TD [(cu)19.7(lt)20.6(ur)15.1(es)-573.4(we)18.8(re)-573.5(ha)19.7(rv)15.1(es)19.9(te)19.5(d)-582.8(b)0(y)-572.4(c)0(e)12.8(n)0(t)20.7(r)0(i)20.7(f)0(u)20.9(g)0(a)19.7(t)0(i)14.8(o)0(n)-572.4(a)0(t)-573.7(3)0(5)20.8(0)0(0)]TJ /F7 1 Tf 22.0597 0 TD (g)Tj /F6 1 Tf 1.0828 0 TD [(fo)15.1(r)]TJ -23.1425 -1.1174 TD [(15)-146.2(mi)19.5(n)-323.6(a)0(t)-314.5(4)]TJ /F8 1 Tf 4.5444 0 TD ()Tj /F6 1 Tf .3859 0 TD [(C)-324.7(\()0(B)19.8(e)0(c)18.5(k)0(m)19.6(a)0(n)-314.4(C)0(o)19.8(u)0(l)14.9(t)0(e)19.6(r)-323.6(Al)19.8(le)19.6(gr)20.9(a)-324.8(2)0(1)20.8(R)0(\))19.8(,)-326(th)20.7(e)-324.8(s)0(u)21(p)0(e)19.7(r)0(n)15.1(a)0(-)]TJ -4.9303 -1.1116 TD [(ta)19.5(nt)20.7(s)-352.2(w)0(e)18.8(r)0(e)-343.1(d)0(i)20.7(s)0(c)19.9(a)0(r)19.7(d)0(e)19.7(d)0(,)-338.6(a)0(n)19.7(d)-352.4(re)19.7(su)21(lt)14.8(in)20.7(g)-346.7(c)0(e)18.5(l)0(l)-342.3(p)0(e)19.7(l)0(l)20.6(e)0(t)19.5(s)-352.2(we)18.8(re)-337.4(wa)18.8(sh)15.3(ed)]TJ T* [(by)-388.1(re)19.7(su)21(sp)15.3(en)19.7(di)20.7(ng)-388.1(in)-382.5(2)20.8(6)-156.6(m)0(L)-390.5(1)]TJ /F8 1 Tf 12.032 0 TD ()Tj /F6 1 Tf .9503 0 TD [(PB)20(S.)-384.5(Th)19.6(e)-399.7(s)0(u)21(s)0(p)21(e)0(n)19.7(s)0(i)15.1(o)0(n)20.8(s)-398.3(we)18.8(re)]TJ -12.9824 -1.1174 TD [(ce)18.5(nt)20.7(ri)15(fu)20.9(ge)19.7(d)-340.9(a)0(g)19.7(a)0(i)19.5(n)0(,)-332.8(t)0(h)15(e)-342.1(su)21(pe)19.7(rn)20.9(at)13.8(an)19.7(t)-341(w)0(a)18.8(s)-340.7(di)14.9(sc)19.9(ar)19.7(de)19.7(d,)-332.8(an)19.7(d)-340.9(w)0(a)18.8(s)0(h)15.3(-)]TJ 0 -1.1116 TD -.0196 Tc [(i)-19.6(n)1.1(g)-331.7(p)-19.6(ro)-19.6(c)-5.7(e)-19.6(du)-19.6(re)-332.9(w)-19.6(a)-.8(s)-331.5(r)-19.6(ep)-19.6(ea)-19.6(te)-19.6(d)-322.5(o)-19.6(nc)-19.6(e)-323.6(m)-19.6(or)-19.6(e)-5.6(.)-328.3(T)-19.6(h)0(e)-332.9()-19.6(na)-19.6(l)-322.6(c)-19.6(el)-19.6(l)-321.6(p)-19.6(el)-19.6(le)-19.6(ts)]TJ T* 0 Tc [(we)18.8(re)-423.8(pa)19.7(rt)20.7(ly)-422.8(dr)15.1(ie)19.6(d)-427.3(b)0(y)-422.7(c)0(e)18.5(n)0(t)14.9(r)0(i)20.7(f)0(u)20.9(g)0(a)19.7(l)-433.2(ev)19.7(ap)19.7(or)20.9(at)13.8(io)20.7(n)-433.1(\()]TJ /F9 1 Tf 19.0358 0 TD (*)Tj /F6 1 Tf .9907 0 TD [(12)-146.2(h;)-422.8(Ce)18.6(n-)]TJ -20.0265 -1.1116 TD [(ti)20.6(Va)18.8(p)-312.1(C)0(o)19.8(n)0(s)21(o)0(l)20.7(e)0(\))13.9(,)-308.7(st)20.9(or)20.9(ed)-302.9(at)]TJ /F8 1 Tf 10.3272 0 TD (-)Tj /F6 1 Tf .5414 0 TD (80)Tj /F8 1 Tf .9792 0 TD ()Tj /F6 1 Tf .3859 0 TD [(C,)-299.3(an)19.7(d)-312.1(u)0(l)20.7(t)0(i)20.6(m)0(a)18.4(t)0(e)19.6(l)0(y)-301.8(a)0(n)19.7(a)0(l)19.5(y)0(z)19.7(e)0(d)-302.9(b)0(y)]TJ -12.2336 -1.1174 TD [(un)20.8(ta)19.5(rg)15.1(et)19.6(ed)-331.7(an)19.7(al)13.8(ys)21(es)-337.2(of)-330.5(th)20.7(e)-347.8(p)0(r)20.9(i)0(m)19.5(a)0(r)19.7(y)-346.7(me)18.4(ta)19.6(bo)20.8(li)20.6(te)19.6(s)-346.5(b)0(y)-336.3(g)0(a)19.7(s)-340.7(ch)19.7(ro)15.1(-)]TJ 0 -1.1116 TD [(ma)18.4(to)20.7(gr)20.9(ap)13.9(hy)20.8(m)19.6(as)19.9(s)-323.4(s)0(p)21(e)0(c)18.5(t)0(r)15(o)0(m)19.6(e)0(t)19.5(r)0(y)-313.2(\()0(G)20(C)0(-)19.8(M)0(S)20.1(\))0(.)]TJ 1.0137 -1.1116 TD [(Ce)18.6(ll)-492(pe)19.7(ll)20.6(et)19.5(s)-502(w)0(e)18.8(r)0(e)-492.9(e)0(x)13.9(t)0(r)20.7(a)0(c)18.5(t)0(e)19.6(d)-502.2(by)-491.8(th)20.7(aw)18.8(in)20.7(g)-502.2(t)0(h)20.7(e)-503.3(sa)14.1(m)15(p)0(l)15(e)0(s)-492.7(o)0(n)]TJ -1.0137 -1.1174 TD [(ic)19.5(e,)-253.4(re)19.7(su)21(sp)21(en)13.9(di)20.7(ng)-249.9(in)-250(a)-255.7(5)0(0)15.1(/)0(5)20.7(0)-260.3(mi)19.5(xt)20.7(ur)20.9(e)-261.4(o)0(f)-249.8(a)0(c)18.5(e)0(t)19.5(o)0(n)20.8(i)0(t)20.6(r)0(i)15(l)0(e)-251.2(a)0(n)19.7(d)-254.5(wa)13(te)19.5(r)]TJ 0 -1.1116 TD (\()Tj /F9 1 Tf .3225 0 TD (*)Tj /F6 1 Tf .9907 0 TD [(1.)18.5(5)-156.6(m)0(L)18.4(/)0(c)19.6(e)0(l)19.5(l)-185.5(pe)19.7(ll)20.6(et)19.5(\),)-171.5(an)19.7(d)-185.4(v)0(o)20.8(r)0(t)20.7(e)0(x)19.7(i)0(n)20.7(g)-185.4(fo)20.9(r)-179.6(3)0()15.1(5)-156.6(m)15(i)0(n)-175.1(a)0(t)-170.5(a)-186.6(se)19.9(tt)20.6(in)20.7(g)-185.4(o)0(f)]TJ -1.3132 -1.1116 TD [(30)20.8(00)-226.8(\(V)20(or)15.1(te)19.5(x)-231.5(G)0(e)13(n)0(i)20.7(e)-232.6(Vo)14.2(rt)20.7(ex)19.7(er)-228(2\))20.9(.)-233.8(N)0(e)18.8(x)0(t)14.9(,)-233.8(sa)19.9(mp)19.6(le)19.6(s)-237(w)0(e)18.8(r)0(e)-228(c)0(l)19.6(a)0(r)14(i)0()20.9(e)0(d)]TJ 0 -1.1174 TD [(by)-244.1(ce)18.5(nt)15(ri)20.7(fu)20.9(ga)19.7(ti)14.8(on)-244.1(\(1)20.9(2,)18.5(00)20.8(0)]TJ /F7 1 Tf 10.1889 0 TD (g)Tj /F6 1 Tf .4896 0 TD [(,)-256.9(4)-156.6(mi)19.5(n,)-246.4(4)]TJ /F8 1 Tf 3.692 0 TD ()Tj /F6 1 Tf .3859 0 TD [(C\))19.8(,)-256.9(a)0(n)19.7(d)-254.5(th)20.7(e)-261.4(s)0(u)21(p)0(e)19.7(r)0(n)20.9(a)0(t)19.5(a)0(n)13.9(t)0(s)]TJ -14.7564 -1.1116 TD [(ca)18.5(re)19.7(fu)15.1(ll)20.6(y)-185.4(t)0(r)15(a)0(n)19.7(s)0(f)21.1(e)0(r)19.7(r)0(e)19.7(d)-191.2(to)-180.9(2)-156.6(m)0(L)-177.4(c)0(e)18.5(n)0(t)20.7(r)0(i)15(f)0(u)20.9(g)0(e)-181.9(t)0(u)20.7(b)0(e)19.7(s)-191(an)19.7(d)-185.4(i)0(m)19.5(m)0(e)18.4(d)0(i)15(a)0(t)19.5(e)0(l)19.6(y)]TJ T* [(dr)20.9(ie)19.5(d)-294.8(t)0(o)]TJ /F9 1 Tf 3.3809 0 TD (*)Tj /F6 1 Tf .9849 0 TD (10)Tj /F9 1 Tf 1.1519 0 TD (m)Tj /F6 1 Tf .5414 0 TD [(L)-290.3(b)0(y)-284.4(c)0(e)18.5(n)0(t)20.7(r)0(i)20.7(f)0(u)20.9(g)0(a)13.9(l)-289.2(ev)19.7(ap)19.7(or)15.1(at)19.5(io)20.7(n)-289.1(\()]TJ /F8 1 Tf 11.9859 0 TD ()Tj /F6 1 Tf .5472 0 TD [(8)-156.6(h)-289.1(at)-285.7(me)18.4(di)20.7(um)]TJ -18.5923 -1.1174 TD [(he)19.7(at)19.5(;)-404.4(D)0(N)19.1(A)-405.1(11)20.8(0)-404.3(S)0(a)19.8(v)0(a)19.7(n)0(t)-394(D)0(N)19.1(A)-399.4(Sp)15.2(ee)18.5(dV)20(ac)18.5(\).)-390.4(Th)19.6(e)-405.4(c)0(o)19.7(n)0(c)19.7(e)0(n)19.7(t)0(r)15(a)0(t)19.6(e)0(d)]TJ 0 -1.1116 TD [(ex)19.7(tr)20.7(ac)12.8(ts)-307.4(we)13(re)-308.6(di)14.9(lu)20.7(te)19.5(d)]TJ /F9 1 Tf 8.6741 0 TD (*)Tj /F6 1 Tf .9849 0 TD [(10)15.1(0-)20.9(fo)20.9(ld)-313.4(us)21(in)20.7(g)-323.6(1)-156.6(mL)-315.6(of)-307.4(50)15.1(/5)20.7(0)-317.9(a)0(c)18.5(e)0(t)13.8(o)0(-)]TJ -9.659 -1.1116 TD [(ni)20.7(tr)15(il)20.6(e/)19.5(H)]TJ 7.3823 0 0 6.5614 94.6771 219.3448 Tm (2)Tj 9.843 0 0 9.843 98.2488 220.9889 Tm [(O,)-276.1(vo)20.8(rt)20.7(ex)13.9(ed)-268.3(ag)13.9(ai)19.5(n,)-269.5(an)19.7(d)-283.3(t)0(r)20.7(a)0(n)13.9(s)0(f)21.1(e)0(r)19.7(r)0(e)19.7(d)-283.3(in)-273(10)]TJ /F9 1 Tf 16.0638 0 TD (m)Tj /F6 1 Tf .5414 0 TD .2845 Tc [(La)284.5(l)304.1(i)284.5(q)305.2(u)284.5(o)299.6(t)284.5(s)]TJ -20.2857 -1.1116 TD 0 Tc [(to)-451.6(mi)19.5(cr)19.7(ov)15.1(ol)20.7(um)19.6(e)-463(g)0(l)20.7(a)0(s)19.9(s)-467.4(in)20.7(se)19.9(rt)20.7(s)-461.7(\()0(A)14.2(m)0(e)18.4(r)0(i)20.7(c)0(a)18.5(n)-461.9(Ch)19.8(ro)20.9(ma)18.4(to)20.7(gr)15.1(ap)19.7(hy)20.8(\),)]TJ 0 -1.1174 TD [(wh)20(ic)19.5(h)-289.1(h)0(a)19.7(d)-283.3(be)19.7(en)-274.1(in)20.7(se)19.9(rt)15(ed)-274.1(in)20.7(to)-273(2)-156.6(m)0(L)-275.3(c)0(e)18.5(n)0(t)20.7(r)0(i)15(f)0(u)20.9(g)0(e)-274.1(t)0(u)20.7(b)0(e)19.7(s)0(.)-275(S)0(a)19.8(m)0(p)13.8(l)0(e)19.6(s)]TJ 0 -1.1116 TD [(we)18.8(re)-354.7(ag)19.7(ai)19.5(n)-364(d)0(r)15.1(i)0(e)19.6(d)-364(by)-353.5(ce)18.5(nt)20.7(ri)20.7(fu)20.9(ga)19.7(l)-364.1(e)0(v)19.7(a)0(p)13.9(o)0(r)20.9(a)0(t)19.5(i)0(o)20.7(n)-364(\()]TJ /F9 1 Tf 18.4656 0 TD (*)Tj /F6 1 Tf .9907 0 TD [(10)-146.2(mi)19.5(n,)-355.9(me)18.4(-)]TJ -19.4563 -1.1116 TD [(di)20.7(um)-308.7(he)19.7(at)19.5(\))-312.1(a)0(n)19.7(d)-317.9(st)20.9(or)20.9(ed)-302.9(at)]TJ /F8 1 Tf 10.1198 0 TD (-)Tj /F6 1 Tf .5414 0 TD (80)Tj /F8 1 Tf .9791 0 TD ()Tj /F6 1 Tf .3859 0 TD [(C)-313.1(o)0(r)-307.4(i)0(m)19.5(m)0(e)18.4(d)0(i)20.7(a)0(t)19.5(e)0(l)19.5(y)-317.9(pr)20.9(ep)19.7(ar)19.7(ed)-302.9(fo)15.1(r)]TJ -12.0263 -1.1174 TD [(GC)18.9(-M)20(S)-260.1(a)0(n)19.7(a)0(l)13.8(y)0(s)21(i)0(s)20.9(.)]TJ 1.0137 -1.1116 TD -.02 Tc [(Sa)-5(mple)-5(s)-245.5(w)1.1(e)-5(r)2(e)-246.9(d)1.9(e)-5(r)2(ivatized)-245.7(by)-245.7(addition)-245.7(of)-245.7(10)]TJ /F9 1 Tf 16.8587 0 TD 0 Tc (m)Tj /F6 1 Tf .5357 0 TD .2263 Tc [(Lo)248.2(f2)248.2(0)75.5(m)247(g)248.2(/)242.4(m)247(L)]TJ -18.408 -1.1116 TD .0122 Tc [(meth)5.3(ox)5.3(yami)5.2(ne)-295.3(hy)5.3(dro)5.3(ch)5.3(lo)5.3(ri)5.2(de)-295.3(in)-294.2(pyr)5.4(id)5.3(in)5.3(e)-301.1(\()5.4(Sig)5.3(m)-1.6(a-Ald)5.3(r)-.4(ich\))5.4(,)]TJ 0 -1.1174 TD .0187 Tc [(fo)-5.4(llo)-5.4(wed)-293.4(b).3(y)-287.7(i).2(n)-5.4(c)-.8(ub)-5.4(atio)-5.4(n)-287.7(a)-.8(t)-293.5(3).3(7)]TJ /F8 1 Tf 12.1645 0 TD 0 Tc ()Tj /F6 1 Tf .4147 0 TD .0186 Tc [(C)-294.5(f).3(or)-293.5(90)-166.8(mi)-5.7(n.)-290.1(Sa)-6.7(mple)-6.7(s)-287.6(w)-.6(e)-6.7(r).3(e)]TJ -12.5792 -1.1116 TD .0188 Tc [(th)-5.3(en)-397(e)-6.5(quil)-5.5(i).3(br)-5.3(ate)-6.5(d)-397(to)-402.8(roo)-5.3(m)-398.2(temp)-5.3(era)-6.5(t).3(ur)-5.3(e,)-399.3(mixe)-6.5(d)-397(w)-.4(i)-5.5(t).3(h)-397(2)]TJ /F9 1 Tf 23.1079 0 TD 0 Tc (m)Tj /F6 1 Tf .5702 0 TD (L)Tj -23.6782 -1.1116 TD .0188 Tc [(of)-270.2(a)-265.7(s).6(t)-5.5(a)-.7(nda)-6.5(rd)-264.5(mi)-5.5(xtu)-5.3(r).5(e)-265.7(o).4(f)-270.2(f).5(at)-5.5(ty)-264.5(ac)-6.5(id)-264.5(met)-5.5(hyl)-270.4(est)-5.5(e)-.7(rs)-264.3(\()-5.3(F).6(AM)-6.2(Es,)]TJ T* .0186 Tc [(C8)-5.5(C10)-5.5(,)-532(e)-.9(ve)-6.7(n)-529.7(c)-.9(h)-5.5(a)-.9(in)-5.5(s)-529.5(f)-5.5(rom)-536.7(C)-.8(12)-5.5(C30)-5.5(\))-529.6(\()-5.5(B)-.8(ard)-5.5(i).1(ng)]TJ /F7 1 Tf 21.6507 0 TD .019 Tc [(et)-535.2(al.)]TJ /F6 1 Tf 2.3903 0 TD 0 Tc (,)Tj -24.041 -1.1174 TD .0185 Tc [(20)-5.6(13\))-5.6(,)-313.2(a)-1(n)-5.6(d)-316.7(sil)-5.8(y).1(lat)-5.8(e)-1(d)-316.7(b).1(y)-316.7(a)-1(d)-5.6(d).1(iti)-5.8(on)-316.7(of)-316.6(90)]TJ /F9 1 Tf 16.2596 0 TD 0 Tc (m)Tj /F6 1 Tf .5702 0 TD .3364 Tc [(Lo)318(f)]TJ /F7 1 Tf 2.1369 0 TD 0 Tc (N)Tj /F6 1 Tf .6854 0 TD .0218 Tc [(-met)3.3(hy)3.4(l)3.3(-)]TJ /F7 1 Tf 3.6229 0 TD 0 Tc (N)Tj /F6 1 Tf .6854 0 TD (-)Tj -23.9604 -1.1116 TD [(\(t)20.7(ri)15(me)18.4(th)20.7(yl)20.7(si)20.9(ly)20.7(l\))15(tr)20.7(i)20.9(uo)20.8(ro)15.1(ac)18.5(et)19.5(am)18.5(id)20.7(e)-520.6(\()-70.2(MS)14.3(TF)19.8(A;)-510.1(Si)20.9(gm)19.6(a-)19.7(Al)19.8(dr)20.9(ic)13.8(h\))]TJ T* -.0274 Tc [(c)-6.6(o).3(n)-5.5(t).2(ai)-5.6(ni)-5.6(ng)-276.2(1%)-277.2(tr)-5.4(im)-6.7(et)-5.6(hy)-5.5(lc)-6.6(hlo)-5.5(r)-5.4(os)-5.3(il)-5.6(an)-5.5(e)-271.6(\()-5.4(Si)-5.6(gma)-6.6(-).3(A)-6.3(l).2(d)-5.5(r).3(i)-5.6(c)-.9(h)-5.5(\)).3(,)-272.7(f)-5.4(ol)-5.6(lo)-5.5(we)-6.6(d)]TJ 0 -1.1174 TD -.023 Tc [(by)-329.4(h)4.7(e)-2.2(ati)4.6(n)-1.1(g)-329.4(a)3.5(t)-335.2(3)4.7(7)]TJ /F8 1 Tf 6.3645 0 TD 0 Tc ()Tj /F6 1 Tf .3686 0 TD -.0275 Tc [(C)-334.9(f)-5.5(or)-339.6(30)-172.6(min)-5.6(.)]TJ 19.7846 67.9242 TD 0 Tc [(Un)20(ta)13.8(rg)20.9(et)19.5(ed)-325.9(an)19.7(al)19.5(ys)21(es)-325.7(we)13(re)-325.9(al)19.5(so)-324.5(pe)19.7(rf)20.9(or)15.1(m)15(e)0(d)-325.9(o)0(n)-324.7(t)0(h)15(e)-330.6(ex)13.9(tr)20.7(ac)18.5(el)19.5(-)]TJ -1.0137 -1.1174 TD [(lu)15(la)19.6(r)-456.1(f)0(r)15.1(a)0(c)18.5(t)0(i)20.6(o)0(n)20.8(s)-461.7(of)-445.7(cu)19.7(lt)14.8(ur)20.9(es)-446.7(gr)15.1(ow)20(n)-456.1(i)0(n)-451.6(t)0(h)20.7(e)-457.3(ab)19.7(se)14.1(nc)19.7(e)-457.3(a)0(n)19.7(d)-461.9(pr)20.9(es)19.9(-)]TJ 0 -1.1116 TD [(en)13.9(ce)-298.3(of)-295.9(0.)18.5(1%)-297(an)19.7(d)-306.4(1)0(.)18.5(0)0(%)-297(\()0(v)20.9(/)0(v)20.7(\))-306.3(Kl)19.8(ee)18.5(no)20.8(l)-312.3(3)0(0)20.8(.)-302.9(Fo)15.2(r)-306.3(t)0(h)20.7(e)0(s)19.9(e)-307.5(sa)19.9(mp)19.6(le)19.5(s,)]TJ T* [(la)13.8(te)19.6(-l)20.7(og)-307.5(cu)19.7(lt)20.6(ur)15.1(es)-302.7(\(2)-151.9(mL)18.4(\))-312.1(w)0(e)13(r)0(e)-302.8(s)0(e)14.1(p)0(a)19.7(r)0(a)19.7(t)0(e)19.6(d)-317.9(by)-307.5(ce)18.5(nt)20.7(ri)20.7(fu)15.1(ga)19.7(ti)20.6(on)-307.5(\(a)19.7(s)]TJ T* [(de)13.9(sc)19.9(ri)20.7(be)19.7(d\))20.9(,)-274.1(a)0(n)13.9(d)-271.8(th)20.7(e)-273(s)0(u)15.3(p)0(e)19.7(r)0(n)20.9(a)0(t)19.5(a)0(n)19.7(t)0(s)-267.1(w)0(e)18.8(r)0(e)-262.5(r)0(e)13.9(m)15(ov)15.1(ed)-262.5(an)19.7(d)-271.8(s)0(e)14.1(p)0(a)19.7(r)0(a)19.7(t)0(e)19.5(d)]TJ 0 -1.1174 TD [(in)15(to)-422.8(50)20.8(0)]TJ /F9 1 Tf 3.6056 0 TD (m)Tj /F6 1 Tf .5414 0 TD [(L)-434.3(a)0(l)13.8(i)0(q)20.7(u)0(o)20.8(t)0(s)20.9(,)-435.4(dr)20.9(ie)13.8(d)-433.1(b)0(y)-422.7(c)0(e)18.5(n)0(t)20.7(r)0(i)15(f)0(u)20.9(g)0(a)19.7(l)-433.2(ev)19.7(ap)13.9(or)20.9(at)19.5(io)20.7(n,)-425(an)19.7(d)]TJ -4.147 -1.1116 TD [(st)15.1(or)20.9(ed)-366.2(at)]TJ /F8 1 Tf 3.8648 0 TD (-)Tj /F6 1 Tf .5414 0 TD (80)Tj /F8 1 Tf .9849 0 TD ()Tj /F6 1 Tf .3859 0 TD [(C.)-362.7(Up)20(on)-359.3(an)13.9(al)19.5(ys)21(is)20.9(,)-372.1(t)0(h)15(e)-370.9(dr)20.9(ie)13.8(d)-369.7(s)0(a)19.9(m)0(p)19.6(l)0(e)19.5(s)-375.3(we)18.8(re)-366.2(di)20.7(-)]TJ -5.777 -1.1116 TD [(re)14(ct)19.5(ly)-411.3(de)19.7(ri)15(va)19.7(ti)20.6(ze)18.5(d)-421.6(u)0(s)21(i)0(n)14.9(g)-421.5(90)]TJ /F9 1 Tf 11.1565 0 TD (m)Tj /F6 1 Tf .5414 0 TD [(L)-422.7(M)0(S)20.1(T)0(F)14(A)-422.4(wi)19.8(th)-411.3(1%)-412.2(tr)15(im)19.5(et)19.5(hy)20.8(l-)]TJ -11.698 -1.1174 TD [(ch)13.9(lo)20.7(ro)20.9(si)20.9(la)19.6(ne)-268.3(\(w)14.2(it)20.6(h)-277.6(F)0(A)20.1(M)0(E)18.7(s)-277.4(st)20.9(an)19.7(da)19.7(rd)15.1(s\))21.1(,)-274.1(f)0(o)15.1(l)0(l)20.6(o)0(w)20(e)0(d)-268.3(b)0(y)-267.1(h)0(e)19.7(a)0(t)19.5(i)0(n)20.7(g)-277.6(at)]TJ 0 -1.1116 TD (37)Tj /F8 1 Tf .9849 0 TD ()Tj /F6 1 Tf .3859 0 TD [(C)-261.3(f)0(o)20.9(r)-266(30)-146.2(mi)19.5(n.)-258(Al)19.8(l)-266.2(s)0(a)19.9(m)0(p)19.6(l)0(e)19.6(s)-265.9(we)18.8(re)-256.8(tr)20.7(an)19.7(sf)21.1(er)19.7(re)14(d)-260.3(t)0(o)-255.8(w)0(i)19.8(d)0(e)-256.8(m)0(o)19.6(u)0(t)20.7(h)]TJ -1.3708 -1.1116 TD [(cr)14(im)19.5(p)-415.8(t)0(o)20.7(p)-421.6(vi)20.7(al)19.5(s)-421.4(\()0(A)20(m)0(e)18.4(r)0(i)20.7(c)0(a)18.5(n)-421.6(Ch)19.8(ro)20.9(ma)18.4(to)20.7(gr)20.9(ap)13.9(hy)-405.4(Su)21(pp)15.1(li)20.6(es)19.9(,)-418.1(N)0(e)18.8(w)]TJ 0 -1.1174 TD [(Je)14.1(rs)21.1(ey)19.7(\))-340.9(a)0(n)19.7(d)-340.9(se)14.1(al)19.5(ed)-331.7(wi)19.8(th)-330.6(an)-331.7(11)-146.2(mm)-333(cr)19.7(im)19.5(p)-340.9(c)0(a)18.5(p)0(.)-332.8(S)0(a)19.8(m)0(p)19.6(l)0(e)19.5(s)-340.7(we)18.8(re)]TJ 0 -1.1116 TD [(an)13.9(al)19.5(yz)19.7(ed)-314.4(by)-313.2(GC)18.9(-M)20(S)-323.5(w)0(i)19.8(t)0(h)20.7(i)0(n)-313.3(2)0(4)-152(h)-317.9(of)-319(de)19.7(ri)20.7(va)19.7(ti)20.6(za)18.5(ti)14.8(on)20.8(.)]TJ 1.0137 -1.1116 TD [(All)-413.4(samples)-414.2(were)-416.5(analyzed)-416.8(on)-411.1(an)-412.3(Agilent)-413.3(Technologies)]TJ -1.0137 -1.1116 TD .0123 Tc [(689)5.4(0N)-646.3(Net)5.3(w)-1.2(o)5.4(r)-.3(k)-645.4(G)-1.2(C)-646.4(S)5.6(ys)5.6(tem)-646.6(c)-1.5(o)5.4(nnect)5.3(ed)-645.4(t)5.3(o)-645.4(an)-645.4(Agi)5.3(l)-.4(en)5.4(t)]TJ 0 -1.1174 TD 0 Tc [(Technologi)-9(es)-383.3(5973)-378.8(Inert)-386.9(Mass)-380.5(Selective)-389.2(Detector)-387.8(and)-384.6(out-)]TJ 0 -1.1116 TD [(tted)-415.7(with)-408.7(a)-405.4(7683B)-409.7(Series)-411.9(Injector.)-412.2(Separations)-412.9(were)-416.5(per-)]TJ T* [(forme)-7.8(d)-248.8(using)-253.1(an)-256.8(Agilent)-257.8(J&WDB-5ms)-258(GC-capillary)-255.1(column)]TJ 0 -1.1174 TD [(\(30)-170.3(m)]TJ /F8 1 Tf 2.4536 0 TD ()Tj /F6 1 Tf .7142 0 TD [(0.25)-168(mm)-304.2(i.d.\))-304(and)-304(an)-302.9(integrated)-308.6(10)-169.2(m)-301.8(guard)-306.1(column.)]TJ -3.1678 -1.1116 TD [(Samples)-327.8(\(1)]TJ /F9 1 Tf 4.7172 0 TD (m)Tj /F6 1 Tf .5529 0 TD [(L\))-320.1(were)-324.4(introduced)-324.6(by)-319(splitless)-322(injection)-323.8(using)]TJ -5.2701 -1.1116 TD [(a)-376.6(constant)-374.1(helium)-372.1(gas)-372.9(\(99.999%)-369.3(purity\))-370.8(ow)-372.6(of)-370.8(1)-168.1(mL/min.)]TJ 0 -1.1174 TD [(Injection)-266(port)-257.9(temperature)-260.1(was)-258.6(maintained)-263.8(at)-256.9(250)]TJ /F8 1 Tf 19.7904 0 TD ()Tj /F6 1 Tf .3974 0 TD [(C,)-253.2(and)-263.6(the)]TJ -20.1878 -1.1116 TD [(separation)-325.6(was)-316.2(performed)-318.6(using)-322.2(an)-314.4(initial)-320.5(oven)-316.6(temperature)]TJ T* [(of)-428.4(60)]TJ /F8 1 Tf 2.2636 0 TD ()Tj /F6 1 Tf .3917 0 TD [(C)-428.3(\(for)-424.8(1)-168.1(min\))-426.2(and)-430.7(a)-422.7(temperature)-432.9(ramp)-427.2(of)-428.4(10)]TJ /F8 1 Tf 18.7306 0 TD ()Tj /F6 1 Tf .3974 0 TD (C/min)Tj -21.7832 -1.1174 TD [(to)-394(320)]TJ /F8 1 Tf 2.6725 0 TD ()Tj /F6 1 Tf .3974 0 TD [(C)-388(\(hold)-391.5(for)-389.1(5)-162.4(min\).)-395.1(Mass)-386.2(spectra)-397(were)-387.7(obtained)-391.5(by)]TJ -3.0699 -1.1116 TD [(elect)-9.3(ron)-492.8(impact)-500(ionization)-497.7(at)-498.8(70)-163.5(eV,)-497.2(using)-500.8(an)-492.9(ion)-498.8(source)]TJ T* [(temperatur)-10.2(e)-411.2(o)0(f)-411.1(230)]TJ /F8 1 Tf 7.9657 0 TD ()Tj /F6 1 Tf .3974 0 TD [(C)-411.1(and)-413.4(collected)-418.1(over)-414.5(a)-417(mass)-409.6(range)-416.7(of)]TJ -8.3631 -1.1116 TD (60600)Tj /F7 1 Tf 3.3349 0 TD (m/z)Tj /F6 1 Tf 1.7221 0 TD [(\(2.71)-330.3(scans/s\).)]TJ -4.0433 -1.1174 TD [(Deconvolution)-375(and)-367.3(identication)-375.4(were)-370.4(performed)-376.2(on)-370.8(the)]TJ -1.0137 -1.1116 TD [(raw)-276(data)-277.6(using)-270.4(the)-275.3(Automated)-273.8(Mass)-276.8(Spectral)-271.6(Deconvolution)]TJ T* [(and)-448(Identication)-450.1(System)-452.3(software)-449.6(\(AMDIS,)-444.5(National)-450.1(In-)]TJ 0 -1.1174 TD [(stitute)-262.6(of)-255.6(Standards)-265.4(and)-257.9(Technology\))-257.7(using)-258.9(a)-261.4(retention)-260.3(index)]TJ 0 -1.1116 TD (of)Tj /F8 1 Tf 1.2383 0 TD ()Tj /F6 1 Tf .5529 0 TD 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[(Dat)4.2(a)-469.1(are)-469.1(a)3.2(vailabl)4.2(e)-469.1(o)-1.4(n)4.3(l)-1.5(i)4.2(n)-1.4(e)-469.1(a)3.2(t)-468.1(w)-2.3(ww.l)4.2(ieberto)4.3(n)-1.4(l)4.2(i)-1.5(ne.co)4.3(m)-2.6(/)4.2(a)-2.6(s)4.5(t)-1.5(\),)]TJ 0 -1.1174 TD .0071 Tc [(e)-6.7(x)-5.5(ce)-6.7(pt)-552.8(fo)-5.5(r)-546.9(t)-5.6(he)-553.9(2P)-5.4(01)-5.5(AA)-553.6(s)-5.3(t).1(r)-5.5(a)-.9(i)-5.6(n).2(,)-549.3(a)-6.7(ll)-552.8(s)-5.3(p).2(a)-6.7(c)-.9(e)-6.7(c)-.9(r)-5.5(a)-.9(f)-5.5(t).1(-)-5.5(a)-6.7(ss)-5.3(oc)-6.7(i)-5.6(a)-.9(t)-5.6(e)-.9(d)]TJ /F7 1 Tf 0 -1.1116 TD [(A)-6.6(c)-.8(i)-5.5(n)-5.4(et)-5.5(ob)-5.4(ac)-6.6(te)-6.6(r)]TJ /F6 1 Tf 6.1686 0 TD .0118 Tc [(st)4.8(rai)4.8(n)-.8(s)-398(g)4.9(rew)-399.1(o)4.9(n)-398.2(e)-2(t)4.8(h)-.8(anol)-398.4(as)-398(the)-399.4(s)5.1(ol)4.8(e)-399.4(c)-2(arbo)4.9(n)]TJ -6.1686 -1.1116 TD .0116 Tc [(sou)4.7(r)-1(ce,)-170.4(w)-1.9(i)4.6(t)-1.1(h)-168(gro)4.7(wt)4.6(h)-173.8(r)-1(ates)-173.6(rang)4.7(in)4.7(g)-173.8(f)-1(r)4.8(o)-1(m)]TJ /F9 1 Tf 15.7586 0 TD 0 Tc (*)Tj /F6 1 Tf 1.0137 0 TD .0072 Tc [(0.3)-5.4(6)-178.2(to)-178.2(0.)-7.7(53)-172.5(h)]TJ /F8 1 Tf 7.3823 0 0 6.5614 531.3259 115.8235 Tm 0 Tc (-)Tj /F6 1 Tf .5683 0 TD (1)Tj 9.843 0 0 9.843 541.0203 111.4582 Tm .0126 Tc [(\(i)5.6(n)]TJ -23.1598 -1.1174 TD .0116 Tc [(16)-168(mM)-353.3(o)4.7(r)-352.3(0.1%)-347.7(v/v)-352.4(e)3.6(th)4.7(an)4.7(ol)4.6(\),)-354.7(where)-353.5(t)4.6(he)-353.5(f)4.8(a)-2.2(st)4.6(es)4.9(t)-352.5(r)-1(ates)-357.9(wer)4.8(e)]TJ 0 -1.1116 TD .0069 Tc [(e)-6.9(x)-5.7(hi)-5.8(bi)-5.8(te)-6.9(d)-270.7(b)-5.7(y)]TJ /F7 1 Tf 5.3911 0 TD .0128 Tc [(A.)-267.1(j)5.8(ohn)5.9(so)5.9(ni)5.8(i)]TJ /F6 1 Tf 5.2471 0 TD .0124 Tc [(2)5.5(P)0(08)5.5(AA)-266(\(0)5.5(.53)]TJ /F8 1 Tf 6.1168 0 TD 0 Tc ()Tj /F6 1 Tf .7315 0 TD .0109 Tc [(0.0)4(3)-168.7(h)]TJ /F8 1 Tf 7.3823 0 0 6.5614 509.4424 93.8834 Tm 0 Tc (-)Tj /F6 1 Tf .5683 0 TD (1)Tj 9.843 0 0 9.843 517.4361 89.5181 Tm .0126 Tc (\).)Tj -19.75 -1.1116 TD 0 Tc [(At)-377.6(10-fold)-376.4(higher)-376.5(concentrations)-377.3(of)-376.5(ethanol)-378.9(\(160)-165.6(mM)-372.9(or)]TJ -1.0137 -1.1174 TD [(1.0%)-336.1(v/v\),)-336.2(rates)-336(for)-331.5(the)-332.9(2P08AA)-336.5(and)-332.8(2P07AA)-336.5(strains)-337(were)]TJ /F9 1 Tf -.1498 -1.1116 TD (*)Tj /F6 1 Tf 1.0137 0 TD .0123 Tc [(1)5.4(.)3.1(5-)5.5(fol)5.3(d)-495.6(l)5.3(ower)-495.6(\()]TJ /F7 1 Tf 7.1075 0 TD 0 Tc (p)Tj /F8 1 Tf .6796 0 TD (<)Tj /F6 1 Tf .7257 0 TD .0115 Tc [(0.0)4.6(5\),)-493(whereas)-496.3(r)4.7(ates)-496.3(f)4.7(o)-1.1(r)-496.4(t)4.5(he)-491.8(50)4.6(v1,)]TJ /F5 1 Tf 8.9663 0 0 8.9663 62.022 749.6502 Tm 0 Tc (4)Tj 47.3776 0 TD [(MOGUL)-332.3(ET)-338.7(AL.)]TJ ET endstream endobj 71 0 obj <>stream /GS1 gs BT /F6 1 Tf 9.843 0 0 9.843 59.7543 479.7353 Tm 0 0 0 rg 0 Tc 0 Tw [(2P)15.2(07)20.8(PB)20(,)-308.7(a)0(n)19.7(d)-312.1(2P)21(07)15.1(PC)-296.8(st)15.1(ra)19.7(in)20.7(s)-311.9(w)0(e)18.8(r)0(e)19.7(,)-314.4(re)19.7(sp)21(ec)18.5(ti)20.6(ve)13.9(ly)20.7(,)-308.7(a)0(n)19.7(d)-312.1(st)20.9(at)19.5(is)15.2(ti)20.6(-)]TJ 0 -1.1116 TD -.0196 Tc [(c)-19.6(a)-1.1(l)-19.6(l)-4.8(y)-279.9(e)-19.6(q)-5.7(u)-19.6(iv)-19.6(al)-19.6(en)-19.6(t)-275.4(a)-19.6(cr)-19.6(os)-19.6(s)-274.8(1)-19.6(6)-275.2(a)-19.6(nd)-285.6(1)-19.6(6)1.2(0)-176.2(m)-19.6(M)-277.4(e)-19.6(th)-19.6(an)-19.6(ol)-19.6(.)-271.9(A)-19.6(s)-275.9(d)-19.6(is)-19.6(pl)-19.6(ay)-19.6(ed)]TJ 0 -1.1174 TD 0 Tc [(in)-157.8(Fi)20.9(gu)15.1(re)-158.8(1B)19.8(,)-164.7(v)0(i)20.7(a)0(b)19.7(l)0(e)-159(c)0(u)19.7(l)0(t)20.6(u)0(r)15.1(e)0(s)-158.7(w)0(e)18.8(r)0(e)-158.8(c)0(o)19.7(n)0()21(r)0(m)19.6(e)0(d)-158.9(b)0(y)-157.7(p)0(l)20.7(a)0(t)19.6(e)-169.3(co)19.7(un)20.8(ts)-157.6(on)]TJ 0 -1.1116 TD [(mi)19.5(d-)15.1(lo)20.7(g)-260.3(p)0(h)20.8(a)0(s)19.9(e)-261.4(cu)19.7(lt)14.8(ur)20.9(es)19.9(,)-262.6(w)0(h)20(i)0(c)19.6(h)-260.3(pr)20.9(ov)20.8(id)20.7(ed)-251(ce)12.8(ll)-250.1(de)19.7(ns)21(it)20.6(ie)19.6(s)-260.1(r)0(a)14(n)0(g)20.8(i)0(n)20.7(g)]TJ T* [(fr)15.1(om)]TJ /F9 1 Tf 2.4479 0 TD (*)Tj /F6 1 Tf .9907 0 TD (4)Tj /F8 1 Tf .6566 0 TD ()Tj /F6 1 Tf .7084 0 TD (10)Tj 7.3823 0 0 6.5614 116.674 440.2771 Tm (8)Tj 9.843 0 0 9.843 125.5181 435.9117 Tm [(to)-514.9(1)]TJ /F8 1 Tf 1.9525 0 TD ()Tj /F6 1 Tf .7142 0 TD (10)Tj 7.3823 0 0 6.5614 161.4047 440.2771 Tm (9)Tj 9.843 0 0 9.843 170.2488 435.9117 Tm [(cf)19.7(u/)15(m)15(L)0(.)-518.3(M)0(o)19.9(s)0(t)-514.7(s)0(t)15.1(r)0(a)19.7(i)0(n)20.7(s)-525(di)20.7(sp)15.3(la)19.6(ye)19.7(d)]TJ -11.2257 -1.1174 TD [(si)15.1(mi)19.5(la)19.6(r)-306.3(c)0(e)12.8(l)0(l)-296.2(d)0(e)19.7(n)0(s)15.3(i)0(t)20.6(i)0(e)19.5(s)-306.2(wh)14.2(en)-297.1(gr)20.9(ow)14.2(n)-306.4(o)0(n)-301.7(1)0(6)-295.9(o)0(r)-301.7(1)0(6)20.8(0)-156.6(mM)-298.1(et)13.8(ha)19.7(no)20.8(l;)]TJ 0 -1.1116 TD [(ho)15.1(we)18.8(ve)19.7(r,)-286.7(pl)20.7(at)19.5(e)-301.8(c)0(o)19.7(u)0(n)20.8(t)0(s)-290.1(f)0(o)20.9(r)-300.6(th)20.7(e)-301.8(2)0(P)21(0)0(7)20.8(P)0(B)-291.1(s)0(t)20.9(r)0(a)19.7(i)0(n)-290.3(w)0(e)18.8(r)0(e)]TJ /F9 1 Tf 20.1763 0 TD (*)Tj /F6 1 Tf .9907 0 TD [(1.)24.3(8-)15.1(fo)20.9(ld)]TJ -21.1669 -1.1116 TD [(hi)14.9(gh)20.8(er)-251(\(1)20.9(.1)]TJ /F8 1 Tf 4.4868 0 TD ()Tj /F6 1 Tf .7084 0 TD (10)Tj 7.3823 0 0 6.5614 120.5291 407.3952 Tm (9)Tj /F8 1 Tf 9.843 0 0 9.843 125.7448 403.0298 Tm ()Tj /F6 1 Tf .7142 0 TD [(1.)24.3(5)]TJ /F8 1 Tf 1.3823 0 TD ()Tj /F6 1 Tf .7084 0 TD (10)Tj 7.3823 0 0 6.5614 163.0488 407.3952 Tm (8)Tj 9.843 0 0 9.843 169.285 403.0298 Tm [(cf)19.7(u/)20.7(mL)18.4(\))-260.3(i)0(n)-250(1)0(6)-146.2(m)0(M)-252(e)0(t)19.5(h)0(a)13.9(n)0(o)20.8(l)0(.)]TJ -10.114 -1.1116 TD -.0157 Tc [(As)-575.3(a)-570.9(s).7(pe)-15.7(c)8.6(i).4(es-)-15.7(l)10.8(eve)-15.7(l)-560.6(comp)-15.7(a)9.7(r).5(is)-15.7(o)11.1(n).5(,)-572.1(gro)-15.7(w)10(t).4(h)-569.7(r)-15.7(a)9.8(t).4(es)-569.5(w)-15.7(e)8.9(re)-570.9(al)-15.7(s)11(o)]TJ -1.0137 -1.1174 TD -.0159 Tc [(me)-15.9(a)8.4(s).5(ur)-15.9(e)9.6(d)-195.5(a)-15.9(c)8.4(ros)-15.9(s)-184.7(a)-202.5(rang)-15.9(e)-186.3(o).3(f)-201.3(e)-.9(th)-15.9(a)9.5(nol)-201.4(con)-15.9(c)9.5(entr)-15.9(a)9.6(tio)-15.9(n)10.7(s)-195.4(\()-15.9(2)10.7(65)-15.9(0)-156.3(m)-.9(M\))]TJ 0 -1.1116 TD 0 Tc [(fo)26.6(r)]TJ /F7 1 Tf 1.342 0 TD [(A)15(.)-205(r)16.4(a)16.2(di)26.5(o)16.2(r)16.4(es)25.6(i)16.1(s)16.4(te)25.3(n)16.2(s)]TJ /F6 1 Tf 6.7273 0 TD [(50)26.6(v)16.2(1)-202.7(a)15(n)16.2(d)]TJ /F7 1 Tf 3.7841 0 TD [(A)15(.)-199.3(ra)26.8(d)16.2(i)16.1(or)26.8(e)15(s)16.4(is)26.7(t)16.1(e)15(ns)]TJ /F6 1 Tf 6.7273 0 TD -.0162 Tc [(439)-16.2(9)10.4(8)]TJ 7.3823 0 0 6.5614 266.5133 374.5133 Tm 0 Tc (T)Tj 9.843 0 0 9.843 270.9354 370.1479 Tm .1993 Tc [(,w)214.6(h)199.3(i)225.8(c)214.3(h)]TJ -21.4549 -1.1116 TD -.0157 Tc [(s)-15.7(e)9.9(rve)-15.7(d)-491.4(a)-.7(s)-500.4(a)-501.8(non)-15.7(s)11.1(p).5(ace)-15.7(c)8.6(r).5(af)-15.7(t)10.8(-).5(as)-15.7(s)11.3(o).5(ci)-15.7(a)9.6(t).4(ed)-500.6(co)-15.7(n)10.9(t).4(ro)-15.7(l)-490.3(for)-500.6(th)-15.7(i)10.8(s)-500.4(st)-15.7(u)10.8(d).5(y)]TJ 0 -1.1174 TD -.016 Tc [(\()-16(F)10.8(ig.)-295.9(2).2(A\).)-295.9(F).3(or)-293.5(the)-294.7(50v1)-293.6(st)-16(r)10.5(a)-1(in)-16(,)-279.7(r).2(ate)-16(s)-278.4(w)-16(e)8.6(re)-294.7(fast)-16(e)9.3(s).4(t)-293.7(a)-1(t)-293.7(8)-166.8(mM)-288.7(e)-16(t)9.3(h-)]TJ 0 -1.1116 TD -.0162 Tc [(a)-16.2(n)9.2(ol)-501.2(\(0)-16.2(.)13.8(4)-16.2(6)]TJ /F8 1 Tf 4.3486 0 TD 0 Tc ()Tj /F6 1 Tf .7027 0 TD -.0156 Tc [(0.02)-166.4(h)]TJ /F8 1 Tf 7.3823 0 0 6.5614 132.548 341.6314 Tm 0 Tc (-)Tj /F6 1 Tf .5299 0 TD (1)Tj 9.843 0 0 9.843 140.0314 337.2661 Tm -.0159 Tc [(\))-500.8(a)-.9(nd)-506.6(gradu)-15.9(a)9.5(lly)-500.8(t)-15.9(r)10.6(end)-15.9(e)9.5(d)-500.8(dow)-15.9(n)9.8(w)-.6(ard)-506.6(b).3(e-)]TJ -8.1557 -1.1116 TD -.0156 Tc [(t)-15.6(w)10(een)-195.2(40)-195.2(a)-15.6(n)9.8(d)-195.2(650)-166.4(mM)-196.1(\()-15.6(f)11.1(rom)-196.5(0.4)-15.6(3)]TJ /F8 1 Tf 12.9939 0 TD 0 Tc ()Tj /F6 1 Tf .7027 0 TD -.0158 Tc [(0.04)-195.4(to)-195.4(0)-15.8(.)14.2(1)-15.8(1)]TJ /F8 1 Tf 4.6884 0 TD 0 Tc ()Tj /F6 1 Tf .7027 0 TD -.0156 Tc [(0.02)-166.4(h)]TJ /F8 1 Tf 7.3823 0 0 6.5614 270.7086 330.6897 Tm 0 Tc (-)Tj /F6 1 Tf .5299 0 TD (1)Tj 9.843 0 0 9.843 278.192 326.3243 Tm -.0162 Tc [(\).)-198.2(For)]TJ 3.3176 15.5858 TD 0 Tc [(t)16.1(h)16.2(e)-244.2(t)0(y)26.5(p)16.2(e)-244.2(s)16.4(tr)26.5(a)15(i)16.1(n,)-229.2(gr)26.6(o)16.2(w)15.3(th)-232.7(r)16.2(a)15(t)16.1(e)0(s)-233.6(w)15.3(e)15(r)16.2(e)-249.9(e)15(s)16.4(s)16.4(e)0(n)25.4(t)16.1(i)16.1(a)15(ll)26.3(y)-243(e)15(qu)26.6(i)16.1(v)16.2(a)15(l)0(e)25.3(n)16.2(t)-243.1(a)15(cr)25.5(o)16.2(s)16.4(s)]TJ 0 -1.1116 TD -.0159 Tc [(the)-404.1(r).3(ange)-404.1(of)-397.1(t)-15.9(e)9.4(ste)-15.9(d)-387.9(eth)-15.9(a)9.5(nol)-403(conce)-15.9(n)9.5(tra)-15.9(t)9.4(ions)-15.9(;)-386.7(o).3(v)-15.9(e)9.5(rall)-15.9(,)-389.2(t).2(he)-398.3(r)-15.9(a)9.6(tes)]TJ 0 -1.1174 TD 0 Tc (\()Tj /F9 1 Tf .3168 0 TD (*)Tj /F6 1 Tf .9849 0 TD -.0156 Tc [(0.22)-172.2(h)]TJ /F8 1 Tf 7.3823 0 0 6.5614 346.7338 462.2172 Tm 0 Tc (-)Tj /F6 1 Tf .5299 0 TD (1)Tj 9.843 0 0 9.843 354.2172 457.7952 Tm -.015 Tc [(\))-367.4(b)1.2(et)-15(w)10.6(een)]TJ /F9 1 Tf 4.291 0 TD 0 Tc (*)Tj /F6 1 Tf .9907 0 TD -.0159 Tc [(2)-368.3(a)-.9(nd)-368.3(4)-15.9(0)-156.3(mM)-369.2(eth)-15.9(a)9.5(nol)-368.5(w)-15.9(e)8.7(re)]TJ /F9 1 Tf 11.2429 0 TD 0 Tc (*)Tj /F6 1 Tf .9849 0 TD -.0161 Tc [(2-)-16.1(f)10.6(o).1(ld)]TJ -21.9157 -1.1116 TD [(lowe)-16.1(r)-244.1(t)0(h)-16.1(a)9.3(n)-253.3(t)-16.1(h)10.4(o).1(se)-260.3(of)-259.1(the)-260.3(50v1)-259.1(str)-16.1(a)9.4(in.)-255.7(F)-16.1(o)10.7(r)-253.3(b)-16.1(o)10.5(th)-259.1(str)-16.1(a)9.4(ins,)-261.4(grow)-16.1(t)9.5(h)-253.4(at)]TJ T* [(conc)-16(e)8.3(n).2(tr)-16(a)9.5(tion)-16(s)]TJ /F8 1 Tf 5.9152 0 TD 0 Tc (<)Tj /F6 1 Tf .5357 0 TD -.016 Tc [(2)-166.8(m)-1(M)-271.4(p)-16(r)10.6(ovi)-16(d)10.5(e)-1(d)-270.5(i).1(r)-16(r)10.7(epr)-16(o)10.6(duci)-16(b)10.5(le)-271.7(re)-16(s)9.6(u).2(lt)-16(s)10.7(.)]TJ -5.4372 -1.1174 TD 0 Tc [(Fo)21(r)-421.5(t)0(h)20.7(e)-422.7(50)20.8(v1)-411.1(st)20.9(ra)19.7(in)20.7(,)-423.9(c)0(u)19.7(l)0(t)20.6(i)0(v)20.7(a)0(t)19.5(i)0(o)15(n)0(s)-410.9(w)0(e)18.8(r)0(e)-412.3(a)0(l)19.5(s)0(o)-410.9(p)0(e)19.7(r)0(f)20.9(o)0(r)15.1(m)15(ed)-412.3(in)]TJ -1.0137 -1.1116 TD [(mi)19.5(xt)20.7(ur)20.9(es)-227.8(of)-221(et)19.5(ha)19.7(no)15.1(l)-231.6(a)0(n)19.7(d)-231.5(2-)15.1(pr)20.9(op)20.8(an)19.7(ol)-227(us)21(in)20.7(g)-237.2(t)0(h)20.7(e)-232.6(mo)19.6(le)-222.4(ra)14(ti)20.6(os)-220.9(of)-226.8(0,)]TJ T* [(0.)18.5(15)20.8(,)-308.7(0)0(.)18.5(5)0(0)20.8(,)-314.5(0.)18.5(85)20.8(,)-314.5(a)0(n)19.7(d)-312.1(1.)18.5(0,)-298.3(at)-308.8(a)-313.3()0(n)21(a)0(l)-303(c)0(o)19.7(n)0(c)19.7(e)0(n)19.7(t)0(r)15(a)0(t)19.5(i)0(o)20.7(n)-312.1(of)-301.7(20)15.1(0)-156.6(m)0(M)]TJ T* [(\(F)21(ig)20.7(.)-435.4(2)0(B)19.8(\))0(.)-425(U)0(s)20.2(i)0(n)15(g)-433.1(th)20.7(es)19.9(e)-434.2(m)0(i)13.7(x)0(t)20.7(u)0(r)20.9(e)0(s)19.9(,)-435.4(re)19.7(pr)20.9(od)15.1(uc)19.7(ib)20.7(le)-424(gr)20.9(ow)14.2(th)-422.8(ra)19.7(te)19.6(s)]TJ 0 -1.1174 TD [(an)19.7(d)-300.6(h)0(i)20.7(g)0(h)-295.9(p)0(l)20.7(a)0(t)19.5(e)-301.8(co)19.7(un)15.1(ts)-290.1(\()]TJ /F9 1 Tf 9.1925 0 TD (*)Tj /F6 1 Tf .9907 0 TD (10)Tj 7.3823 0 0 6.5614 420.718 385.455 Tm (8)Tj 9.843 0 0 9.843 427.4077 381.0897 Tm [(cf)19.7(u/)20.7(mL)18.4(\))-306.3(w)0(e)18.8(r)0(e)-291.3(o)0(b)20.8(t)0(a)13.8(i)0(n)20.7(e)0(d)-291.3(a)0(t)-291.5(m)0(o)19.6(l)0(e)]TJ -11.842 -1.1116 TD [(ra)19.7(ti)20.6(os)-267(of)-267.1(0.)18.5(15)20.8(,)-274.1(0)0(.)18.5(5)0(0)20.8(,)-279.9(an)19.7(d)-271.8(0)0(.)18.5(8)0(5)20.8(.)-279.9(Fo)21(r)-277.5(i)0(n)20.7(s)0(t)20.9(a)0(n)19.7(c)0(e)18.5(,)-279.9(cu)19.7(lt)20.6(ur)20.9(es)-268.1(gr)20.9(ow)14.2(n)-271.8(i)0(n)]TJ T* [(mi)19.5(xt)20.7(ur)20.9(es)-417.9(of)-422.6(17)20.8(0)-156.6(m)0(M)-419(e)0(t)19.6(h)0(a)19.7(n)0(o)20.8(l)-427.4(an)19.7(d)-427.3(3)0(0)-146.2(m)0(M)-419(2)0(-)15.1(p)0(r)20.9(o)0(p)20.8(a)0(n)19.7(o)0(l)-417(\()0(m)19.6(o)0(l)20.7(e)]TJ 0 -1.1174 TD [(fr)20.9(ac)18.5(ti)20.6(on)-405.4(of)-405.3(0.)18.5(15)20.8(\),)-407.7(10)20.8(0)-156.6(m)0(M)-407.5(e)0(t)19.5(h)0(a)19.7(n)0(o)15.1(l)-410.2(an)13.9(d)-415.8(1)0(0)20.8(0)-156.6(mM)-407.5(2-)20.9(pr)20.9(op)20.8(an)19.7(ol)]TJ 0 -1.1116 TD [(\(m)19.6(ol)20.7(e)-353.6(f)0(r)20.9(a)0(c)18.5(t)0(i)20.6(o)0(n)-342(o)0(f)-336.2(0)0(.)18.5(5)0(0)20.8(\))0(,)-344.3(a)0(n)19.7(d)-346.7(30)-152(m)15(M)-353.3(et)19.6(ha)19.7(no)20.8(l)-352.6(a)0(n)19.7(d)-352.4(17)20.8(0)-156.6(m)0(M)-338.4(2)0(-)]TJ T* [(pr)20.9(op)20.8(an)19.7(ol)-497.7(\(m)19.6(ol)14.9(e)-503.3(f)0(r)15.1(a)0(c)18.5(t)0(i)20.6(o)0(n)-497.5(o)0(f)-497.5(0)0(.)18.5(8)0(5)20.8(\))-507.9(ex)19.7(hi)20.7(bi)14.9(te)19.5(d)-507.9(m)0(i)19.5(d)0(-)20.9(l)0(o)20.7(g)-507.9(ph)20.8(as)19.9(e)]TJ ET q 1 i 59.754 729.241 m 550.091 729.241 l 550.091 545.386 l 59.754 545.386 l W n q 490.48 0 0 183.855 59.754 545.386 cm /Im1 Do Q Q BT /F10 1 Tf 9.845 0 0 9.845 59.7543 531.0991 Tm [(FIG.)-371.3(1.)-1000.6(\(A\))]TJ /F6 1 Tf 5.9025 0 TD [(Gr)20.2(ow)20.2(th)-347.7(ra)14.1(te)19.7(s)-357.9(a)0(n)19.9(d)]TJ /F10 1 Tf 7.3594 0 TD [(\(B)20.1(\))]TJ /F6 1 Tf 1.67 0 TD [(mi)19.7(d-)21.1(lo)20.9(g)-358(p)0(h)21.1(a)0(s)14.3(e)-359.2(pl)20.9(at)19.7(e)-359.2(c)0(o)19.9(u)0(n)21.1(t)0(s)-347.5(f)0(o)21.1(r)-358(di)20.9(ff)15.3(er)19.9(in)20.9(g)-358(s)0(t)21(r)0(a)14.1(i)0(n)20.9(s)-357.9(of)-347.5(sp)21.2(ac)18.7(ec)18.7(ra)19.9(ft)15.1(-a)19.9(ss)21.4(oc)19.9(ia)19.7(te)13.9(d)]TJ /F7 1 Tf 29.3398 0 TD [(Ac)13(in)20.9(et)19.7(ob)21(ac)19.9(te)19.7(r)]TJ /F6 1 Tf -44.2717 -1.0135 TD [(\(5)15.3(0v)21.1(1,)-275(2P)21.2(01)21.1(AA)19.4(,)-285.5(2)0(P)21.2(0)0(8)21.1(A)0(A)13.6(,)-279.8(2P)15.5(07)21.1(AA)19.4(,)-285.5(2)0(P)21.2(0)0(7)21.1(P)0(B)20.2(,)-285.5(an)19.9(d)-288.9(2)0(P)21.2(0)0(7)21.1(P)0(C)20.2(\))-283.2(cu)14.1(lt)20.7(iv)20.9(at)19.7(ed)-273.8(in)-278.6(0.)18.7(2)]TJ /F8 1 Tf 30.6067 0 TD ()Tj /F6 1 Tf .7083 0 TD [(M9)-273.4(\(3)21(2)]TJ /F8 1 Tf 2.9599 0 TD ()Tj /F6 1 Tf .3858 0 TD [(C\))-279.4(co)19.9(nt)20.9(ai)19.7(ni)20.9(ng)-278.4(26)]TJ /F9 1 Tf 6.8584 0 TD (m)Tj /F6 1 Tf .5413 0 TD .284 Tc [(MF)284(e)]TJ 7.3837 0 0 6.5625 494.9857 525.5432 Tm 0 Tc (2)Tj /F8 1 Tf .4914 0 TD (+)Tj /F6 1 Tf 9.845 0 0 9.845 505.4739 521.1211 Tm [(an)19.9(d)-288.9(1)0(6)-145.9(m)0(M)]TJ -45.2737 -1.0077 TD [(\(0)15.3(.)13.9(1)0(%)-250.6(v)0(/)20.9(v)0(\))-249.6(o)0(r)-243.8(1)0(6)21.1(0)-156.5(mM)-251.6(\(1)21(.0)18.7(%)-255.4(v)0(/)20.9(v)0(\))-249.6(e)0(t)19.7(h)0(a)19.9(n)0(o)21.1(l)0(;)-250(t)0(h)20.9(e)-261.3(re)19.9(sp)21.2(ec)18.7(ti)20.7(ve)-250.8(gr)21.1(ow)20.2(th)-249.8(cu)19.9(rv)21.1(es)-250.6(ar)19.9(e)-261.3(p)0(r)21(o)0(v)21.1(i)0(d)20.9(e)0(d)-250.8(i)0(n)-244(S)0(u)15.5(p)0(p)21(l)0(e)19.7(m)0(e)18.7(n)0(t)20.9(a)0(r)19.9(y)-260.1(Fi)21.1(gu)21.1(re)-250.8(S1)-243.7(\(X)-250.4(de)19.9(ma)18.7(rk)21(s)]TJ 0 -1.0135 TD [(no)-255.4(me)18.7(as)20(ur)21.1(ab)14.1(le)-250.9(gr)21.1(ow)20.2(th)15.1(,)]TJ /F7 1 Tf 9.2885 0 TD (n)Tj /F8 1 Tf .6565 0 TD (=)Tj /F6 1 Tf .7083 0 TD [(6)21.1(7,)-252(er)19.9(ro)21(rs)-255.2(ba)19.9(rs)-255.2(in)]TJ /F10 1 Tf 7.4631 0 TD [(\(A)20.2(\))]TJ /F6 1 Tf 1.6239 0 TD [(re)19.9(pr)15.3(es)20.1(en)19.9(t)-266.1(t)0(h)20.9(e)-261.3(st)21(an)14.1(da)19.9(rd)-249.6(er)14.1(ro)21.1(r)-260.1(o)0(f)-255.4(r)0(e)19.9(g)0(r)21(e)0(s)14.3(s)0(i)21(o)0(n)-249.6(a)0(n)14.1(d)-260.1(in)]TJ /F10 1 Tf 19.1932 0 TD [(\(B)20.1(\))]TJ /F6 1 Tf 1.5721 0 TD -.0197 Tc [(t)-19.7(h)1.2(e)-286.8(s)-19.7(ta)-19.7(nd)-19.7(ar)-19.7(d)-275.1(d)-19.7(ev)-19.7(ia)-19.7(ti)-19.7(on)-19.7(\).)]TJ ET q 490.48 0 0 163.162 59.754 141.392 cm /Im2 Do Q BT /F10 1 Tf 9.845 0 0 9.845 59.7543 127.1055 Tm 0 Tc [(FIG.)-244.6(2.)-1000.6(\(A\))]TJ /F6 1 Tf 5.6491 0 TD [(Growth)-243.9(rates)-237.6(of)]TJ /F7 1 Tf 6.5014 0 TD [(Acinetobacter)-243.7(radioresistens)]TJ /F6 1 Tf 11.782 0 TD [(50v1)-240.1(and)]TJ /F7 1 Tf 3.9273 0 TD [(A.)-241.6(radioresistens)]TJ /F6 1 Tf 7.0081 0 TD (43998)Tj 7.3837 0 0 6.5625 427.6345 131.4709 Tm (T)Tj 9.845 0 0 9.845 434.5511 127.1055 Tm [(cultivated)-244.5(\(32)]TJ /F8 1 Tf 5.5455 0 TD ()Tj /F6 1 Tf .3916 0 TD [(C\))-244.8(in)-238.3(0.2)]TJ /F8 1 Tf 3.6797 0 TD ()Tj /F6 1 Tf .7198 0 TD (M9)Tj -48.4063 -1.0135 TD [(and)-292.1(26)]TJ /F9 1 Tf 2.9081 0 TD (m)Tj /F6 1 Tf .5471 0 TD .2897 Tc [(MF)289.7(e)]TJ 7.3837 0 0 6.5625 115.2 121.4929 Tm 0 Tc (2)Tj /F8 1 Tf .4991 0 TD (+)Tj /F6 1 Tf 9.845 0 0 9.845 125.8582 117.1275 Tm [(containing)-289.2(2650)-166.2(mM)-291.9(ethanol)-286(\()]TJ /F7 1 Tf 12.7264 0 TD (n)Tj /F8 1 Tf .668 0 TD (=)Tj /F6 1 Tf .7198 0 TD [(26,)-288.5(errors)-289.1(bars)-292.9(represent)-294.6(the)-286.5(standard)-292.4(error)-294.1(of)-284.2(regression\);)]TJ /F10 1 Tf 24.1629 0 TD (\(B\))Tj /F6 1 Tf 1.6239 0 TD (mid-log)Tj -46.6154 -1.0135 TD [(phase)-404.5(plate)-399.2(counts)-398.7(of)]TJ /F7 1 Tf 9.2828 0 TD [(A.)-397.1(radioresistens)]TJ /F6 1 Tf 7.3249 0 TD [(50v1)-395.5(obtained)-402.2(from)-396.7(cultivations)-400.7(\(32)]TJ /F8 1 Tf 15.0183 0 TD ()Tj /F6 1 Tf .3916 0 TD [(C\))-400.3(in)-399.5(0.2)]TJ /F8 1 Tf 3.9964 0 TD ()Tj /F6 1 Tf .7198 0 TD [(M9)-394.4(and)-401.5(26)]TJ /F9 1 Tf 4.7911 0 TD (m)Tj /F6 1 Tf .5528 0 TD .3992 Tc [(MF)399.2(e)]TJ 7.3837 0 0 6.5625 496.5164 111.5149 Tm 0 Tc (2)Tj /F8 1 Tf .4991 0 TD (+)Tj /F6 1 Tf 9.845 0 0 9.845 508.1951 107.1496 Tm (containing)Tj -45.5501 -1.0135 TD [(200)-170(mM)-268.9(ethanol)-274.5(\(mole)-266.6(ratio)-271.4(0\),)-270.2(170)-170(mM)-268.9(ethanol,)-272.1(and)-269(30)-169(mM)-268.9(2-propanol)-270.4(\(mole)-272.4(ratio)-271.4(0.15\),)-269.8(100)-164.2(mM)-268.9(ethanol)-274.5(and)-269(100)-164.2(mM)-274.6(2-)]TJ 0 -1.0077 TD [(propanol)-308.7(\(mole)-301.1(ratio)-305.9(0.50\),)-304.4(30)-169(mM)-303.4(ethanol)-303.3(and)-303.6(170)-170(mM)-303.4(2-propanol)-304.9(\(mole)-301.2(ratio)-305.9(0.85\),)-304.4(and)-303.6(200)-164.2(mM)-309.2(2-propanol)-304.9(\(mole)-301.1(ratio)]TJ 0 -1.0135 TD [(1.0\))-374.9(\(*demarks)-375(statistical)-377.9(signicance)-378.4(of)]TJ /F7 1 Tf 17.1086 0 TD (p)Tj /F8 1 Tf .6622 0 TD (<)Tj /F6 1 Tf .7198 0 TD [(0.05,)-372.5(X)-376.1(demarks)-373.1(no)-376.3(growth,)]TJ /F7 1 Tf 12.0642 0 TD (n)Tj /F8 1 Tf .6622 0 TD (=)Tj /F6 1 Tf .7198 0 TD [(511,)-375.9(and)-372.7(error)-374.7(bars)-373.5(represent)-375.2(the)-378.6(standard)]TJ -31.9369 -1.0135 TD [(deviation\);)-244.3(and)]TJ /F10 1 Tf 6.2883 0 TD (\(C\))Tj /F6 1 Tf 1.6239 0 TD [(growth)-243(rates)-243.4(of)]TJ /F7 1 Tf 6.2826 0 TD [(A.)-241.6(radioresistens)]TJ /F6 1 Tf 7.0139 0 TD [(50v1)-240.1(cultivated)-244.5(\(32)]TJ /F8 1 Tf 7.7856 0 TD ()Tj /F6 1 Tf .3916 0 TD [(C\))-244.8(in)-238.3(0.2)]TJ /F8 1 Tf 3.6797 0 TD ()Tj /F6 1 Tf .7198 0 TD [(M9)-238.9(and)-246(26)]TJ /F9 1 Tf 4.4802 0 TD (m)Tj /F6 1 Tf .5528 0 TD .2437 Tc [(MF)243.7(e)]TJ 7.3837 0 0 6.5625 462.8408 71.6598 Tm 0 Tc (2)Tj /F8 1 Tf .5068 0 TD (+)Tj /F6 1 Tf 9.845 0 0 9.845 472.9889 67.2945 Tm [(containing)-243.1(200)-170(mM)]TJ -41.974 -1.0077 TD [(ethanol)-337.9(\(mole)-335.7(ratio)-334.7(0;)-330.4(triangles\))-340.8(or)-330.2(170)-170(mM)-332.2(ethanol)-337.9(and)-332.4(30)-163.2(mM)-338(2-propanol)-333.7(\(mole)-335.7(ratio)-334.7(0.15;)-330(squares\).)]TJ /F5 1 Tf 8.9663 0 0 8.9663 59.7543 749.7069 Tm [(SURVIVAL)-340.1(ON)-334.6(SPACECRAFT)-335.2(CLEANING)-337.5(REAGENTS)-28647.3(5)]TJ ET endstream endobj 73 0 obj <>stream AdobedC        s!1AQa"q2B#R3b$r%C4Scs5D'6Tdt& EFVU(eufv7GWgw8HXhx)9IYiy*:JZjz?>iZ'|dWӕ N4 T]y? H5f99^_Go7;YN@חj*sr.VoS?uvʜ˯/#՛T]y? H5f99^_Go7;YN@חj*sr.VoS?uvʜ˯/#՛T]y? H5f99^_Go7;YN@חj*sr.VoS?uvʜ˯/#՛T]y? H5f99^_Go7;YN@חj*sr.VoS?uvʜ˯/#՛T]y? H5f99^_Go7;YN@חj*sr.VoS?uvʜ˯/#՛T]y? H5f99^_Go7;YN@חj*sr.VoS?uvʜ˯/#՛T]y? H5f99^_Go7;YN@חj*sr.VoS?uvʜ˯/#՛T]y? H5f99^_Go eZsJum̅Ai^4O*|ɖg2{([<&F_JVvA G;YN@חj*sr.VoS?uvʜ˯/#՛T]y? H5f99^_Go7;YN@חj*sr.VoS?uvʜ˯/#՛T]y? H5f99^_Go7;YN@חj*sr.VoS?uvʜ˯/#՛T]y? H5f99^_Go7;YN@חj*sr.VoS?uvʜ˯/#՛T]y? H5f99^_Go7;YN@חj*sr.VoS?uvʜ˯/#՛T]y? H5f99^_Go7;YN@חj*sr.VoS?uvʜ˯/#՛T]y? H5f99^_Go7;YN@חj*sr.VoS?uvʜ˯/#՛T]y? H5f99^_Go7;YN@חj*sr.VoS?uvʜ˯/#՛T]y? 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/F6 1 Tf .6969 0 TD -.0179 Tc (0.5)Tj /F8 1 Tf 1.3593 0 TD 0 Tc ()Tj /F6 1 Tf .6969 0 TD -.0162 Tc (10)Tj 7.3823 0 0 6.5614 261.7511 674.7021 Tm 0 Tc (8)Tj 9.843 0 0 9.843 267.6472 670.3369 Tm -.0208 Tc [(cfu/m)-5.8(L)0(\),)]TJ -20.8905 -1.1116 TD 0 Tc [(an)19.7(d)]TJ /F9 1 Tf 1.7625 0 TD (*)Tj /F6 1 Tf .9907 0 TD [(1.)18.5(7-)20.9(fo)20.9(ld)-324.9(hi)20.7(gh)15.1(er)-325.9(th)20.7(an)-325.9(th)20.7(os)21(e)-336.3(o)0(b)20.8(t)0(a)13.8(i)0(n)20.7(e)0(d)-325.9(\()0(i)20.7(n)-335.2(co)19.7(nt)20.7(ro)20.9(l)-335.3(e)0(x)19.7(p)0(e)13.9(r)0(-)]TJ -2.7531 -1.1116 TD [(im)19.5(en)19.7(ts)15.1(\))-335.1(a)0(t)-331.8(1)0(7)15.1(0)-156.6(mM)-326.9(et)19.5(ha)13.9(no)20.8(l)-341(\()0(4)20.9(.)0(7)]TJ /F8 1 Tf 12.9363 0 TD ()Tj /F6 1 Tf .7084 0 TD (10)Tj 7.3823 0 0 6.5614 205.9653 652.8187 Tm (8)Tj /F8 1 Tf 9.843 0 0 9.843 211.181 648.4534 Tm ()Tj /F6 1 Tf .7084 0 TD [(1.)18.5(6)]TJ /F8 1 Tf 1.3881 0 TD ()Tj /F6 1 Tf .7084 0 TD (10)Tj 7.3823 0 0 6.5614 248.4283 652.8187 Tm (8)Tj 9.843 0 0 9.843 255.5149 648.4534 Tm [(cf)19.7(u/)20.7(mL)18.4(\).)-332.8(In)]TJ -19.6579 -1.1174 TD -.016 Tc [(c)-16(o)3.7(n)-16(t)4.7(r)-16(a)-2(s)-16(t)4.9(,)-255.6(grow)-16(t)9.6(h)-184.1(rat)-16(e)9.3(s)-183.9(a)-1(t)-190(t).1(he)-185.3(r)-16(e)9.5(spe)-16(c)8.3(tiv)-16(e)-174.9(m)-1(ole)-191(r).2(atio)-16(s)-173.5(o).2(f)-189.9(0).2(.15)-184.1(a)-1(n)-16(d)-173.7(0)]TJ 0 -1.1116 TD -.0157 Tc [(\(a)-15.7(s)-681.2(measu)-15.7(r)10.9(ed)-690.7(t)-15.7(h)10.8(roug)-15.7(h)-680.3(OD\))-690.6(w)-15.7(e)8.9(re)-691.8(st)-15.7(a)9.6(tis)-15.7(t)11(i).4(cal)-15.7(l)10.6(y)-690.7(equ)-15.7(i)10.8(val)-15.7(e)9.6(nt,)]TJ T* -.0154 Tc [(amo)-15.4(u)11.2(n).8(tin)-15.4(g)-397.7(t).7(o)-408.2(0).8(.33)]TJ /F8 1 Tf 7.5855 0 TD 0 Tc ()Tj /F6 1 Tf .7027 0 TD -.0153 Tc [(0.04)-408.1(an)-15.3(d)-397.6(0).9(.30)]TJ /F8 1 Tf 5.7655 0 TD 0 Tc ()Tj /F6 1 Tf .7027 0 TD [(0.)30(01)-140.4(h)]TJ /F8 1 Tf 7.3823 0 0 6.5614 230.3432 619.9368 Tm (-)Tj /F6 1 Tf .5299 0 TD (1)Tj 9.843 0 0 9.843 241.8519 615.5715 Tm .3951 Tc [(\()411.3(F)411.4(i)395.1(g)421.6(.2)411.3(C)410.3(\))411.3(.F)411.4(u)411.3(r)395.1(-)]TJ -18.2698 -1.1174 TD -.0156 Tc [(th)-15.6(e)9.8(r).6(mor)-15.6(e)9.9(,)-387.7(a)-.6(t)-391.2(a)-386.5(mo)-15.6(l)10.9(e)-392.2(ratio)-391.1(of)-391(0.50)-15.6(,)-377.2(a)-.6(nd)-391.1(when)-391.1(com)-15.6(p)9.8(ared)-391.1(wi)-15.6(t)10.7(h)]TJ 0 -1.1116 TD 0 Tc [(t)16.1(h)0(e)-279.8(2)16.2(00)-140.4(m)15(M)-290(e)15(t)0(h)26.5(a)15(n)16.2(o)0(l)-278.8(c)15(on)26.6(t)16.1(r)16.2(ol)26.5(,)-291.4(t)16.1(h)16.2(e)-296(p)16.2(l)16.1(at)25.3(e)-290.2(c)0(o)25.4(u)16.2(n)16.2(t)0(s)-278.6(w)15.3(er)25.5(e)]TJ /F9 1 Tf 20.2108 0 TD (*)Tj /F6 1 Tf .9849 0 TD -.0162 Tc [(1)-16.2(.)8.1(5-fo)-16.2(l)10.3(d)]TJ -21.1957 -1.1116 TD -.0156 Tc [(hi)-15.6(g)10.9(h).6(er)-396.8(\()]TJ /F7 1 Tf 3.3521 0 TD 0 Tc (p)Tj /F8 1 Tf .6508 0 TD (<)Tj /F6 1 Tf .7084 0 TD -.016 Tc [(0.05\),)-399.6(and)-397.2(t).1(he)-398.4(gr)-16(o)10.6(w)-.7(th)-397.2(ra)-16(t)9.3(e)-392.6(w)-16(a)8.6(s)]TJ /F9 1 Tf 12.9017 0 TD 0 Tc (*)Tj /F6 1 Tf .9849 0 TD -.0159 Tc [(1.3-f)-15.9(o)10.7(l).2(d)-397.1(l).2(ow)-15.9(e)8.7(r)]TJ -18.5981 -1.1116 TD -.0162 Tc [(\(0)-16.2(.)13.8(2)-16.2(5)]TJ /F8 1 Tf 2.1772 0 TD 0 Tc ()Tj /F6 1 Tf .7027 0 TD -.0156 Tc [(0.01)-166.4(h)]TJ /F8 1 Tf 7.3823 0 0 6.5614 113.4425 576.1132 Tm 0 Tc (-)Tj /F6 1 Tf .5299 0 TD (1)Tj 9.843 0 0 9.843 120.9259 571.7479 Tm -.0158 Tc [(\).)-410.9(Fina)-15.8(l)9.5(l).3(y,)-410.9(at)-408.7(a)-409.7(m)-.8(o)-15.8(l)10.7(e)-409.7(r).4(at)-15.8(i)10.5(o)-408.6(of)-408.5(0)-15.8(.)14.2(8)-15.8(5)10.8(,)-410.9(a)-.8(nd)-408.6(wh)-15.8(e)9.6(n)]TJ -5.9843 -1.1174 TD [(com)-15.8(p)9.6(ared)-362.5(with)-356.7(t)-15.8(h)10.7(e)-357.9(200)-166.6(mM)-357.6(e)-15.8(t)9.5(han)-15.8(o)10.8(l)-356.8(c)-.8(ont)-15.8(r)10.7(o).4(l,)-359(th)-15.8(e)-347.5(p).4(lat)-15.8(e)-347.6(count)-15.8(s)]TJ 0 -1.1116 TD -.0159 Tc [(wer)-15.9(e)-261.1(st)-15.9(a)9.4(tis)-15.9(t)10.8(i).2(ca)-15.9(l)9.4(l).2(y)-270.4(e)-15.9(q)9.5(u).3(iv)-15.9(a)9.5(l).2(ent)-15.9(,)-262.5(whil)-15.9(e)-261.3(t).2(he)-277.3(gro)-15.9(w)9.8(t).2(h)-270.4(r)-15.9(a)9.6(t).2(e)-271.6(w)-15.9(a)8.7(s)]TJ /F9 1 Tf 21.7659 0 TD 0 Tc (*)Tj /F6 1 Tf .9849 0 TD [(1.)30(5-)]TJ -22.7508 -1.1116 TD -.0159 Tc [(fo)-15.9(l)10.6(d)-270.4(low)-15.9(e)8.7(r)-270.4(\(0.21)]TJ /F8 1 Tf 6.4797 0 TD 0 Tc ()Tj /F6 1 Tf .7027 0 TD -.0156 Tc [(0.02)-166.4(h)]TJ /F8 1 Tf 7.3823 0 0 6.5614 155.7921 543.2313 Tm 0 Tc (-)Tj /F6 1 Tf .5299 0 TD (1)Tj 9.843 0 0 9.843 163.2755 538.866 Tm -.0162 Tc (\).)Tj -9.2731 -1.1174 TD 0 Tc [(To)19.6(ge)19.7(th)20.7(er)19.7(,)-262.6(t)0(h)20.7(e)0(s)14.1(e)-261.4(tr)20.7(en)19.7(ds)-255.4(in)20.7(di)20.7(ca)18.5(te)19.6(d)-260.3(t)0(h)15(a)0(t)-251.2(c)0(e)18.5(l)0(l)-250.1(v)0(i)20.7(a)0(b)19.7(i)0(l)14.8(i)0(t)20.6(i)0(e)19.6(s)-260.1(at)-256.9(mi)19.5(d-)]TJ -1.0137 -1.1116 TD [(lo)20.7(g)-358.2(p)0(h)20.8(a)0(s)19.9(e)-359.4(we)18.8(re)-348.9(m)15(a)0(x)13.9(i)0(m)19.5(a)0(l)19.5(l)0(y)-342.1(e)0(n)13.9(h)0(a)19.7(n)0(c)19.7(e)0(d)-343.2(i)0(n)-347.9(t)0(h)20.7(e)-359.4(pr)20.9(es)19.9(en)19.7(ce)-350.1(of)-347.7(lo)20.7(w)]TJ T* [(mo)19.6(le)-153.2(ra)19.7(ti)20.6(os)-151.8(of)-151.9(2-)20.9(pr)20.9(op)15.1(an)19.7(ol)20.7(,)-158.9(a)0(n)19.7(d)-162.4(th)20.7(at)-153.2(a)-163.5(c)0(o)19.7(n)0(c)19.7(e)0(n)19.7(t)0(r)20.7(a)0(t)19.6(i)0(o)15(n)-156.6(of)-151.9(30)-146.2(mM)-154.1(2-)]TJ 0 -1.1174 TD [(pr)20.9(op)15.1(an)19.7(ol)-175.1(wa)18.8(s)-185.2(n)0(o)20.8(t)-191.3(in)20.7(hi)20.7(bi)20.7(to)20.7(ry)15.1(,)-182(a)0(s)-181.7(t)0(h)20.7(e)-186.6(gr)20.9(ow)20(th)-180.9(ra)19.7(te)-176.3(wa)18.8(s)-185.2(u)0(n)15.1(a)0(f)19.7(f)0(e)19.7(c)0(t)19.6(e)0(d)19.7(.)]TJ 0 -1.1116 TD [(At)-371.8(a)-382.4(h)0(i)20.7(g)0(h)20.8(e)0(r)-371.9(m)0(o)19.6(l)0(e)-372.1(r)0(a)14(t)0(i)20.6(o)-381.2(of)-370.8(0.)18.5(85)20.8(,)-377.8(h)0(o)15.1(w)0(e)18.8(v)0(e)19.7(r)0(,)-367.4(l)0(o)15(n)0(g)20.8(e)0(r)-372(c)0(u)19.7(l)0(t)20.6(i)0(v)20.7(a)0(t)13.8(i)0(o)20.7(n)]TJ T* [(ti)20.6(me)18.4(s)-340.7(w)0(e)18.8(r)0(e)-325.9(r)0(e)19.7(q)0(u)15.1(i)0(r)20.7(e)0(d)-325.9(t)0(o)-330.6(r)0(e)19.7(a)0(c)18.5(h)-335.2(mi)19.5(d-)20.9(lo)15(g)-335.2(p)0(h)20.8(a)0(s)19.9(e)0(,)-328.2(a)0(s)-331.5(i)0(n)20.7(d)0(i)20.7(c)0(a)18.5(t)0(e)19.6(d)-340.9(by)]TJ 0 -1.1174 TD [(th)20.7(e)-296(s)0(l)20.9(o)0(w)20(e)0(r)-279.8(g)0(r)15.1(o)0(w)20(t)0(h)-278.8(r)0(a)19.7(t)0(e)19.6(s)-294.6(\(i)20.7(n)-289.1(1)0(7)15.1(0)-156.6(m)15(M)-295.7(2-)20.9(pr)20.9(op)20.8(an)19.7(ol)14.9(\),)-281(an)19.7(d)-289.1(c)0(e)18.5(l)0(l)-284.7(v)0(i)20.7(-)]TJ 0 -1.1116 TD [(ab)19.7(il)20.6(it)14.8(ie)19.6(s)-265.8(a)0(t)-251.2(m)0(i)19.5(d)0(-)15.1(l)0(o)20.7(g)-266(ph)20.8(as)19.9(e)-267.2(w)0(e)18.8(r)0(e)-256.8(n)0(o)20.8(t)-266.2(en)19.7(ha)19.7(nc)19.7(ed)19.7(.)-268.4(U)0(n)20(s)0(u)21(r)0(p)20.9(r)0(i)20.7(s)0(i)15.1(n)0(g)20.8(l)0(y)20.7(,)]TJ T* [(no)-215.3(gr)20.9(ow)20(th)-215.4(wa)18.8(s)-219.8(o)0(b)20.8(s)0(e)14.1(r)0(v)20.9(e)0(d)-210.7(u)0(n)20.8(d)0(e)13.9(r)-219.9(th)20.7(es)19.9(e)-226.9(c)0(o)19.7(n)0(d)20.8(i)0(t)20.6(i)0(o)15(n)0(s)-209.4(w)0(h)20(e)0(n)-216.5(u)0(s)21(i)0(n)20.7(g)-225.7(2-)]TJ T* [(pr)20.9(op)15.1(an)19.7(ol)-250(as)-250.8(a)-261.4(s)0(o)21(l)0(e)-251.2(c)0(a)18.5(r)0(b)20.9(o)0(n)-249.9(s)0(o)15.3(u)0(r)20.9(c)0(e)-252.2(\()0(m)19.6(o)0(l)20.7(e)-261.4(ra)19.7(ti)20.6(o)-260.3(o)0(f)-255.6(1)0(.)24.3(0)0(\))15.1(.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 62.022 407.3385 Tm [(3.2.)-502.8(Oxidative)-335.3(extremotolerance)-335.1(under)]TJ 0 -1.2203 TD [(ultraminimal)-337(conditions)]TJ /F6 1 Tf 9.843 0 0 9.843 72 379.9558 Tm [(The)-431.9(extremotolerance)-440.9(of)]TJ /F7 1 Tf 10.667 0 TD [(A.)-437.7(radioresistens)]TJ /F6 1 Tf 7.3955 0 TD [(50v1)-436.4(toward)]TJ -19.0761 -1.1174 TD [(aqueous)-418.8(hydrogen)-413.1(peroxide)-420.2(\(H)]TJ 7.3823 0 0 6.5614 188.7307 367.3133 Tm (2)Tj 9.843 0 0 9.843 192.4157 368.9574 Tm (O)Tj 7.3823 0 0 6.5614 199.5023 367.3133 Tm (2)Tj 9.843 0 0 9.843 203.1873 368.9574 Tm [(\))-415.8(was)-414.1(measured)-422.2(in)-411.3(both)]TJ -14.3417 -1.1116 TD [(nutrient-rich)-368.4(\(LB\))-363.7(and)-361.6(ultraminimal)-370(\(0.2)]TJ /F8 1 Tf 16.8183 0 TD ()Tj /F6 1 Tf .72 0 TD [(M9,)-357.9(16)-169.2(mM)-361.4(eth-)]TJ -17.5383 -1.1116 TD [(anol,)-746.4(26)]TJ /F9 1 Tf 3.8705 0 TD (m)Tj /F6 1 Tf .5472 0 TD .7335 Tc [(MF)733.5(e)]TJ 7.3823 0 0 6.5614 131.074 351.4393 Tm 0 Tc (2)Tj /F8 1 Tf .4915 0 TD (+)Tj /F6 1 Tf 9.843 0 0 9.843 138.6708 347.0739 Tm [(\))-738.3(m)0(e)18.4(d)0(i)20.7(a)0(.)-725.7(F)0(o)21(r)-738.3(mi)19.5(d-)20.9(lo)20.7(g)-738.3(p)0(h)20.8(a)0(s)19.9(e)-739.5(cu)19.7(lt)20.6(ur)15.1(es)]TJ -7.7871 -1.1174 TD [(\(1)20.9(.5)]TJ /F8 1 Tf 1.7106 0 TD ()Tj /F6 1 Tf .7084 0 TD (10)Tj 7.3823 0 0 6.5614 95.4708 340.4976 Tm (8)Tj /F8 1 Tf 9.843 0 0 9.843 100.7433 336.0755 Tm ()Tj /F6 1 Tf .7084 0 TD [(0.)18.5(4)]TJ /F8 1 Tf 1.3881 0 TD ()Tj /F6 1 Tf .7084 0 TD (10)Tj 7.3823 0 0 6.5614 137.9905 340.4976 Tm (8)Tj 9.843 0 0 9.843 144.2267 336.0755 Tm [(cf)19.7(u/)20.7(mL)18.4(\),)-252.2(ex)19.7(po)20.8(su)21(re)19.7(s)-260.1(o)0(f)-249.8(1)0(0)-146.2(m)0(M)-252(H)]TJ 7.3823 0 0 6.5614 269.8582 334.4881 Tm (2)Tj 9.843 0 0 9.843 273.4298 336.0755 Tm (O)Tj 7.3823 0 0 6.5614 280.403 334.4881 Tm (2)Tj 9.843 0 0 9.843 286.6393 336.0755 Tm [(\(f)15.1(or)]TJ -22.82 -1.1116 TD -.0199 Tc [(1)-176.5(h)-19.9(\))-246.7(i)-19.9(n)-241.1(u)-19.9(l)-5(t)-19.9(ra)-19.9(mi)-19.9(ni)-19.9(ma)-19.9(l)-248(m)-19.9(ed)-19.9(iu)-19.9(m)-242.2(r)-19.9(es)-19.9(u)-4.6(l)-19.9(te)-19.9(d)-242.1(i)-19.9(n)-246.9(a)]TJ /F9 1 Tf 16.5476 0 TD 0 Tc (*)Tj /F6 1 Tf .9907 0 TD [(1.)18.5(5-)20.9(lo)15(g)-231.5(r)0(e)19.7(d)0(u)20.8(c)0(t)13.8(i)0(o)20.7(n)]TJ -17.5383 -1.1116 TD [(in)-405.5(su)15.3(rv)20.9(iv)20.7(al)-406.7(\(5)20.9(.3)]TJ /F8 1 Tf 6.4739 0 TD ()Tj /F6 1 Tf .7084 0 TD (10)Tj 7.3823 0 0 6.5614 142.3559 318.5574 Tm (6)Tj /F8 1 Tf 9.843 0 0 9.843 147.6283 314.192 Tm ()Tj /F6 1 Tf .7084 0 TD [(2.)18.5(4)]TJ /F8 1 Tf 1.3881 0 TD ()Tj /F6 1 Tf .7084 0 TD (10)Tj 7.3823 0 0 6.5614 184.8755 318.5574 Tm (6)Tj 9.843 0 0 9.843 192.6425 314.192 Tm [(cf)14(u/)20.7(mL)18.4(\).)-407.7(In)-405.3(sh)21(ar)19.7(p)-415.8(c)0(o)13.9(n)0(t)20.7(r)0(a)19.7(s)0(t)20.9(,)]TJ -13.2704 -1.1116 TD [(ex)19.7(po)20.8(su)15.3(re)19.7(s)-317.7(t)0(o)-307.6(m)0(i)19.5(d)0(-)20.9(l)0(o)20.7(g)-317.9(ph)20.8(as)19.9(e)-319(c)0(u)19.7(l)0(t)14.8(u)0(r)20.9(e)0(s)-308.4(i)0(n)-307.6(n)0(u)20.8(t)0(r)20.7(i)0(e)19.6(n)0(t)20.7(-)0(r)15.1(i)0(c)19.5(h)-317.9(me)18.4(di)20.7(um)]TJ 0 -1.1174 TD [(re)19.7(su)15.3(lt)20.6(ed)-377.7(in)-382.5(no)-376.6(lo)15(ss)-376.2(in)-382.5(su)21(rv)15.1(iv)20.7(al)-377.9(\(1)20.9(.9)]TJ /F8 1 Tf 14.3705 0 TD ()Tj /F6 1 Tf .7084 0 TD (10)Tj 7.3823 0 0 6.5614 220.0818 296.6172 Tm (9)Tj /F8 1 Tf 9.843 0 0 9.843 225.3543 292.2519 Tm ()Tj /F6 1 Tf .7084 0 TD [(0.)18.5(4)]TJ /F8 1 Tf 1.3881 0 TD ()Tj /F6 1 Tf .7084 0 TD (10)Tj 7.3823 0 0 6.5614 262.6015 296.6172 Tm (9)Tj 9.843 0 0 9.843 270.1417 292.2519 Tm [(cf)19.7(u/)20.7(mL)18.4(,)]TJ -21.1439 -1.1116 TD [(10)-146.2(mM)-401.7(H)]TJ 7.3823 0 0 6.5614 100.6299 279.666 Tm (2)Tj 9.843 0 0 9.843 104.2582 281.3102 Tm (O)Tj 7.3823 0 0 6.5614 111.2315 279.666 Tm (2)Tj 9.843 0 0 9.843 114.8031 281.3102 Tm [(,)-412.4(1)-156.6(h\))20.9(.)-412.4(F)0(u)21(r)0(t)20.7(h)0(e)19.7(r)0(m)19.6(o)0(r)15.1(e)0(,)-397.4(a)0(t)-400.9(1)0(0)15.1(0)-156.6(mM)-401.7(H)]TJ 7.3823 0 0 6.5614 251.6031 279.666 Tm (2)Tj 9.843 0 0 9.843 255.1747 281.3102 Tm (O)Tj 7.3823 0 0 6.5614 262.148 279.666 Tm (2)Tj 9.843 0 0 9.843 265.7763 281.3102 Tm .4066 Tc [(,n)406.6(o)7(v)406.6(i)421.5(a)406.6(-)]TJ -20.7004 -1.1116 TD 0 Tc [(bi)20.7(li)20.6(ty)-394(wa)18.8(s)-398.3(o)0(b)20.8(s)0(e)19.9(r)0(v)15.1(e)0(d)-389.3(i)0(n)-388.2(u)0(l)20.7(t)0(r)20.7(a)0(m)18.5(i)0(n)20.7(i)0(m)19.5(a)0(l)-395.2(m)0(e)18.4(d)0(i)20.7(u)0(m)19.6(;)-398.6(wh)20(er)19.7(ea)18.5(s)-398.3(o)0(n)15.1(l)0(y)]TJ 0 -1.1174 TD (a)Tj /F9 1 Tf .8524 0 TD (*)Tj /F6 1 Tf .9907 0 TD [(1-)15.1(lo)20.7(g)-404.3(r)0(e)19.7(d)0(u)20.8(c)0(t)13.8(i)0(o)20.7(n)-404.3(wa)18.8(s)-409.8(m)0(e)18.4(a)0(s)19.9(u)0(r)20.9(e)0(d)-400.8(i)0(n)-394(n)0(u)20.8(t)0(r)15(i)0(e)19.6(n)0(t)20.7(-)0(r)20.9(i)0(c)19.6(h)-410(me)18.4(di)20.7(um)]TJ -1.8431 -1.1116 TD .0109 Tc [(\(3)4(.0)]TJ /F8 1 Tf 1.7913 0 TD 0 Tc ()Tj /F6 1 Tf .7257 0 TD .0126 Tc (10)Tj 7.3823 0 0 6.5614 96.8882 252.7936 Tm 0 Tc (8)Tj /F8 1 Tf 9.843 0 0 9.843 102.274 248.4283 Tm ()Tj /F6 1 Tf .7315 0 TD .0109 Tc (0.4)Tj /F8 1 Tf 1.4457 0 TD 0 Tc ()Tj /F6 1 Tf .7315 0 TD .0069 Tc (10)Tj 7.3823 0 0 6.5614 140.9385 252.7936 Tm 0 Tc (8)Tj 9.843 0 0 9.843 147.1181 248.4283 Tm .0135 Tc [(c)5.5(f).9(u)6.6(/).8(m)5.4(L)-.3(\))6.7(.)-237.6(Th)6.6(es)6.8(e)-242.2(r)6.7(es)6.8(ult)6.5(s)-240.8(r)6.7(e)-.3(v)6.6(e)-.3(a)5.5(l).8(e)5.5(d)-241(a)-236.4(p).9(o)6.6(s)1.1(-)]TJ -8.6453 -1.1116 TD .0124 Tc [(it)5.4(iv)5.5(e)-393(c)4.4(or)5.6(relat)5.4(i)-.3(o)5.5(n)-391.9(b)5.5(e)-1.4(t)5.4(w)-1.1(een)-386.1(n)-.2(u)5.5(t)-.3(r)5.6(i)-.3(en)5.5(t)-386.2(a)-1.4(v)5.5(a)-1.4(il)5.4(ab)5.5(il)5.4(ity)-386.1(and)-386.1(s)0(u)5.5(rvi)5.4(v-)]TJ 0 -1.1174 TD .0131 Tc [(ab)6.2(il)6.1(it)6.1(y,)-566.3(as)-563.8(\(e)5.1(xpe)5.1(ct)6.1(ed)6.2(ly)6.2(\))-569.7(o).5(x)6.2(i).4(d)6.2(a)-.7(t)6.1(i).4(v)6.2(e)-570.9(e)5.1(x).5(tr)6.3(em)5(ot)6.1(ol)6.1(era)5.1(n).5(c)5.1(e)-570.9(w)5.4(a)-.7(s)]TJ 0 -1.1116 TD 0 Tc [(si)20.9(gn)15.1(i)20.9(ca)18.5(nt)20.7(ly)-394(en)19.7(ha)19.7(nc)19.7(ed)-395(un)20.8(de)19.7(r)-404.2(n)0(u)20.8(t)0(r)20.7(i)0(e)19.6(n)0(t)20.7(-)0(r)15.1(i)0(c)19.6(h)-398.5(co)13.9(nd)20.8(it)20.6(io)20.7(ns)21(.)-400.8(H)0(o)14.2(w)0(-)]TJ T* [(ev)19.7(er)19.7(,)-516(e)0(x)19.7(p)0(o)20.8(s)0(u)15.3(r)0(e)19.7(s)-513.5(to)-503.4(10)-146.2(mM)-505.4(H)]TJ 7.3823 0 0 6.5614 182.0976 202.9606 Tm (2)Tj 9.843 0 0 9.843 185.6692 204.6047 Tm (O)Tj 7.3823 0 0 6.5614 192.6992 202.9606 Tm (2)Tj 9.843 0 0 9.843 201.4299 204.6047 Tm [(in)-503.4(ul)20.7(tr)20.7(am)18.5(in)15(im)19.5(al)-504.6(me)18.4(di)20.7(um)]TJ -14.1631 -1.1174 TD [(re)19.7(su)15.3(lt)20.6(ed)-400.8(in)-399.7(ap)19.7(pr)20.9(ec)12.8(ia)19.6(bl)20.7(e)-411.2(s)0(u)21(r)0(v)20.9(i)0(v)15(a)0(l)19.5(s)0(,)-401.8(a)0(s)-400.6(e)0(x)19.7(p)0(o)20.8(s)0(u)15.3(r)0(e)19.7(s)-409.8(to)]TJ /F9 1 Tf 20.5794 0 TD (*)Tj /F6 1 Tf .9907 0 TD (5)Tj /F8 1 Tf .6566 0 TD ()Tj /F6 1 Tf .7084 0 TD (10)Tj 7.3823 0 0 6.5614 297.4109 198.0283 Tm (6)Tj 9.843 0 0 9.843 62.022 182.6645 Tm [(cf)19.7(u/)20.7(mL)-315.6(yi)20.7(el)13.8(de)19.7(d)-323.6(o)0(n)20.8(l)0(y)-313.3(a)0(n)]TJ /F9 1 Tf 9.7915 0 TD (*)Tj /F6 1 Tf .9907 0 TD [(30)20.8(-f)20.9(ol)20.7(d)-323.6(l)0(o)20.7(s)0(s)-318.6(i)0(n)-313.3(v)0(i)20.7(a)0(b)19.7(i)0(l)20.6(i)0(t)20.6(y)0(.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 62.022 160.7811 Tm [(3.3.)-502.8(Stable)-334.1(isotope)-333.8(labeling)]TJ /F6 1 Tf 9.843 0 0 9.843 72 144.3401 Tm [(Cultivation)-360.5(on)-359.3(ethanol)-361.6(as)-360.3(a)-359.4(sole)-356.8(carbon)-360.2(source)-365.8(was)-356.5(con-)]TJ -1.0137 -1.1174 TD [(rmed)-629.8(by)-630(untargeted)-636.8(metabolomics)-635.7(analysis)-633.1(and)-632.3(stable)]TJ 0 -1.1116 TD [(isotope)-694.3(proling)-688.5(using)]TJ 7.3823 0 0 6.5614 166.1669 126.7653 Tm (13)Tj 9.843 0 0 9.843 173.5936 122.3999 Tm [(C-labeled)-694.3(ethanol)-695.7(\([1,2-)]TJ 7.3823 0 0 6.5614 276.8881 126.7653 Tm (13)Tj 9.843 0 0 9.843 284.3149 122.3999 Tm (C)Tj 7.3823 0 0 6.5614 290.8912 120.7559 Tm (2)Tj 9.843 0 0 9.843 294.5763 122.3999 Tm (]-)Tj -23.6263 -1.1116 TD [(ethanol\).)-366.1(Cultures)-362.4(of)]TJ /F7 1 Tf 8.8584 0 TD [(A.)-357.1(radioresistens)]TJ /F6 1 Tf 7.2515 0 TD [(50v1)-361.5(were)-364.7(prepared)]TJ -16.1099 -1.1174 TD [(in)-670.5(ultraminimal)-675.2(medium)-672.7(\(0.2)]TJ /F8 1 Tf 13.0342 0 TD ()Tj /F6 1 Tf .7142 0 TD [(M9,)-674.7(26)]TJ /F9 1 Tf 3.4731 0 TD (m)Tj /F6 1 Tf .5529 0 TD .6701 Tc [(MF)670.1(e)]TJ 7.3823 0 0 6.5614 262.148 104.8819 Tm 0 Tc (2)Tj /F8 1 Tf .4992 0 TD (+)Tj /F6 1 Tf 9.843 0 0 9.843 269.9149 100.4598 Tm [(\))-669.2(using)]TJ -21.1208 -1.1116 TD [(16)-169.2(mM)-315.4(ethanol)-321.3(or)]TJ 7.3823 0 0 6.5614 136.6299 93.8834 Tm (13)Tj 9.843 0 0 9.843 144 89.5181 Tm [(C-labeled)-325.7(ethanol,)-319(and)-315.5(the)-321.4(cell)-318(extracts)]TJ -8.3285 -1.1116 TD [(were)-335.9(analyzed)-336.1(by)-336.3(GC-MS)-336.4(\(Supplementary)-337(Fig.)-335(S2A,)-330(B\).)]TJ 1.0137 -1.1174 TD [(As)-325.4(li)14.8(st)20.9(ed)-325.9(in)-330.6(Su)21(pp)20.8(le)19.5(me)18.4(nt)20.7(ar)13.9(y)-335.2(T)0(a)18.5(b)0(l)20.7(e)-336.3(S1)15.2(,)-337.5(c)0(u)19.7(l)0(t)20.6(i)0(v)20.7(a)0(t)19.5(i)0(o)20.7(n)0(s)-330.3(o)0(n)-324.7(e)0(t)13.8(h)0(-)]TJ -1.0137 -1.1116 TD [(an)19.7(ol)-244.2(in)-244.2(ul)20.7(tr)15(am)18.5(in)20.7(im)19.5(al)-245.4(me)18.4(di)20.7(um)-245.3(yi)20.7(el)19.5(de)19.7(d)-254.5(a)0(n)-245.3(a)0(r)19.7(r)0(a)19.7(y)-254.5(of)-244.1(me)18.4(ta)19.6(bo)15.1(li)20.6(te)19.6(s,)]TJ 25.504 67.9184 TD [(in)15(cl)19.5(ud)20.8(in)20.7(g)-300.6(c)0(i)13.8(t)0(r)20.7(i)0(c)-291.5(a)0(c)18.5(i)0(d)-290.3(c)0(y)13.9(c)0(l)19.5(e)-301.8(in)20.7(te)19.6(rm)19.6(ed)19.7(ia)13.8(te)19.6(s)-300.4(\()0(m)19.6(a)0(l)19.5(a)0(t)19.5(e)-307.5(an)19.7(d)-300.6(c)0(i)19.5(t)0(r)20.8(a)0(t)19.5(e)0(\))14(,)]TJ 0 -1.1174 TD .013 Tc [(mo)6.1(no)-304.9(and)-304.9(d).4(i)6(s).6(a)5(c)-.8(c)5(h).4(a)5(r).4(id)6.1(es)-304.7(\(f)6.2(ruc)5(to)6.1(se)5(,)-307.2(g).4(lu)6.1(co)6.1(se)5(,)-307.2(a)-.8(n)6.1(d)-310.6(t)6(r).4(eh)6.1(al)6(os)6.3(e\),)]TJ 0 -1.1116 TD .3199 Tc [(a)306.1(m)311.8(i)307.2(n)307.3(oa)311.9(c)306.1(i)312.9(d)307.3(s)2.2(\()307.3(a)311.9(s)307.5(p)307.3(,c)311.9(y)307.3(s)313.2(,g)307.3(l)312.9(u)307.3(,g)313(l)307.2(n)313(,g)307.3(l)312.9(y)307.3(,i)312.9(l)307.2(e)306.1(,)5.5(l)307.2(y)307.3(s)313.2(,m)311.8(e)306.1(t)307.2(,)5.5(p)307.3(h)307.3(e)311.9(,p)313(r)307.3(o)307.3(,)]TJ T* -.0159 Tc [(s)-15.9(e)9.7(r,)-272.8(thr)-15.9(,)-256.5(t)-15.9(r)10.6(p,)-272.8(tyr)-15.9(,)-256.5(an)-15.9(d)-260(v).3(al\))-15.9(,)-256.5(mo)-15.9(d)10.7(i).2(e)-15.9(d)-261.2(amino)-270.4(a)-15.9(c)8.4(ids)-270.2(\()-15.9(2)10.7(-ox)-15.9(o)10.7(pro)-15.9(l)10.6(i).1(ne)-15.9(,)]TJ T* [(h)-16(o)10.6(mos)-16(e)9.6(rine)-16(,)-522.8(orni)-16(t)10.3(h).2(in)-16(e)9.4(,)-532(and)]TJ /F9 1 Tf 11.4906 0 TD 0 Tc (b)Tj /F6 1 Tf .5357 0 TD -.0159 Tc [(-ala)-15.9(n)9.5(i).2(ne)-15.9(\))9.6(,)-531.9(pept)-15.9(i)10.4(d).3(es)-535.2(\(gl)-15.9(y)10.6(c)-.9(ylg)-15.9(l)10.6(y-)]TJ -12.0263 -1.1174 TD -.0158 Tc [(c)-15.8(i)9.5(ne\))-15.8(,)-319.8(s)-15.8(h)11(ort)-333.8(a)-15.8(n)9.6(d)-333.7(l).2(on)-15.8(g)-323.3(c)-.8(hain)-333.7(f)-15.8(a)9.7(tty)-333.7(a)-15.8(c)8.5(i).3(ds)-333.5(\()-15.8(1)10.8(1-o)-15.8(c)9.6(t).3(ad)-15.8(e)9.6(cenoi)-15.8(c)-324.6(acid)-15.8(,)]TJ 0 -1.1116 TD -.016 Tc [(2)-16(-)10.6(but)-16(e)9.3(n).2(edi)-16(o)10.5(ic)-404.2(ac)-16(i)9.3(d).2(,)-405.3(2-he)-16(x)9.4(e)-1(ned)-16(i)10.5(oic)-404.2(a)-16(c)8.3(i)0(d,)-405.3(2-p)-16(r)10.6(ope)-16(n)9.4(o).2(ic)-404.2(a)-16(c)8.3(id,)-405.3(9).2(-)]TJ T* -.0158 Tc [(o)-15.8(c)9.6(tad)-15.8(e)9.6(ceno)-15.8(i)10.7(c)-634.3(acid,)-635.5(buta)-15.8(n)9.6(edio)-15.8(i)10.7(c)-634.3(acid)-15.8(,)-619.3(hyd)-15.8(r)10.8(oxy)-15.8(b)10.8(u).4(tyr)-15.8(i)10.7(c)-634.3(acid)-15.8(,)]TJ 0 -1.1174 TD 0 Tc [(my)25.4(r)16.2(i)16.1(st)26.7(i)16.1(c)-273(a)15(c)15(i)16(d,)-258(n)16.2(o)16.2(n)0(a)25.4(n)16.2(o)16.2(i)0(c)-256.9(a)15(ci)25.3(d)16.2(,)-268.4(pa)25.4(l)16.1(m)15(i)16.1(t)0(i)26.3(c)-267.2(ac)24.3(i)16.1(d)16.2(,)-274.1(p)16.2(e)15(n)16.2(ta)25.3(n)16.2(e)15(d)16.2(i)0(o)26.5(i)16(c)-273(a)15(c)15(i)16(d,)]TJ 0 -1.1116 TD -.0157 Tc [(p)-15.7(r)10.9(opa)-15.7(n)9.7(o).5(ic)-179.2(a)-15.7(c)8.6(id,)-180.4(a)-.7(nd)-178.1(s)-15.7(t)11(ear)-15.7(i)10.8(c)-179.2(aci)-15.7(d)10.8(\)).5(,)-180.4(f).5(att)-15.7(y)-167.8(alco)-15.7(h)10.9(o).5(ls)-183.6(\(1-h)-15.7(e)9.7(x).5(ade)-15.7(c)8.6(anol)-15.7(,)]TJ T* -.0159 Tc [(1)-15.9(-)10.7(oct)-15.9(a)9.4(deca)-15.9(n)9.5(o).3(l,)-508.9(2)-15.9(-)10.7(dode)-15.9(c)8.4(a)-.9(nol)-15.9(\))10.6(,)-508.9(nu)-15.9(c)9.5(l).1(eob)-15.9(a)9.5(ses)-512.1(\().3(ade)-15.9(n)9.5(ine)-513.5(a)-.9(nd)-512.3(py-)]TJ 0 -1.1174 TD 0 Tc [(ri)26.5(m)15(i)16.1(di)26.5(n)16.2(e)15(\))16.2(,)-279.9(a)15(n)0(d)-267.1(a)-278.7(v)16.2(a)15(ri)26.5(e)15(t)16.1(y)-277.6(o)0(f)-267.1(o)16.2(t)16.1(h)16.2(er)-268.3(m)15(e)15(t)16(ab)25.4(o)16.2(l)16.1(i)16(t)0(e)25.3(s)-277.4(\()]TJ /F7 1 Tf 17.9991 0 TD [(e.)28.9(g.)]TJ /F6 1 Tf 1.3881 0 TD [(,)-279.9(3)16.2(-a)25.5(m)15(i)16.1(n)16.2(o)0(-)26.6(2)16.2(-)]TJ -19.3872 -1.1116 TD -.016 Tc [(p)-16(i)10.5(per)-16(i)10.5(don)-16(e)9.4(,)-336.2(3-)-16(h)10.6(ydr)-16(o)10.6(xyi)-16(s)10.7(ova)-16(l)9.3(e)-1(ric)-340.8(a)-1(c)-16(i)9.3(d,)-342(4-hyd)-16(r)10.6(oxy)-16(b)10.6(e)-1(nzo)-16(i)10.5(c)-340.8(acid)-16(,)]TJ T* -.0158 Tc [(4)-15.8(-)10.8(hyd)-15.8(r)10.8(oxy)-15.8(p)10.8(h).4(eny)-15.8(l)10.7(lac)-15.8(t)9.5(ic)-323.3(aci)-15.8(d)10.7(,)-318.7(be)-15.8(n)9.6(zene)-15.8(p)9.6(rop)-15.8(a)9.6(noic)-323.3(a)-15.8(c)8.5(i).2(d,)-324.5(dimet)-15.8(h)10.7(y).4(l)]TJ T* .0121 Tc [(tar)5.3(t)-.6(arate,)-406(homog)5.2(en)5.2(ti)5.1(sic)-404.9(a)4.1(ci)5.1(d,)-406(in)5.2(do)5.2(le-2-)5.3(carb)5.2(ox)5.2(yli)5.1(c)-404.9(aci)5.1(d,)]TJ /F7 1 Tf 23.2865 0 TD 0 Tc (N)Tj /F6 1 Tf .6739 0 TD (-)Tj -23.9604 -1.1174 TD .0132 Tc [(eth)6.3(y).6(l)6.2(d).6(i)6.2(e)-.6(t)6.2(h).6(an)6.3(ol)6.2(am)5.1(in)6.3(e,)-266.7(a)5.2(n).6(d)-264.4(o).6(x)6.3(a)-.6(li)6.2(c)-271.3(a)5.2(ci)6.2(d\))6.4(.)]TJ 1.0137 -1.1116 TD -.0159 Tc [(Co)-15.9(n)10.7().4(rma)-15.9(t)9.4(ion)-569.9(o).3(f)-569.9(e)-.9(tha)-15.9(n)9.5(ol)-570.1(incor)-15.9(p)10.7(ora)-15.9(t)9.4(i).2(on)-569.9(was)-569.7(obt)-15.9(a)9.4(i).2(ned)-569.9(b).3(y)]TJ -1.0137 -1.1116 TD -.0157 Tc [(c)-15.7(o)9.7(mpar)-15.7(i)10.8(s).7(on)-189.6(o)-15.7(f)-179.1(thes)-15.7(e)-180.1(metab)-15.7(o)10.9(l).4(it)-15.7(e)9.6(s)-189.4(wit)-15.7(h)-179.3(thos)-15.7(e)-180.1(e)-.7(xtr)-15.7(a)9.8(cted)-195.3(from)-190.8(ce)-15.7(l)9.6(l).4(s)]TJ 0 -1.1174 TD -.0159 Tc [(c)-15.9(u)9.5(lti)-15.9(v)10.6(a)-.9(ted)-253.1(o).3(n)]TJ 7.3823 0 0 6.5614 365.1589 532.2329 Tm -.0239 Tc (13)Tj 9.843 0 0 9.843 372.2456 527.8676 Tm -.0159 Tc [(C-l)-15.9(a)9.4(bele)-15.9(d)-238.1(e)-.9(t)-15.9(h)10.6(anol)-15.9(.)-239.4(A)-.6(s)-253(r).3(epre)-15.9(s)9.7(e)-.9(nt)-15.9(a)9.4(tiv)-15.9(e)-238.1(e)-.9(xa)-15.9(m)8.3(p).3(les)-15.9(,)]TJ -6.0131 -1.1116 TD [(m)-15.9(a)8.3(ss)-322.1(spec)-15.9(t)9.4(r).3(a)-323.4(for)-322.2(olei)-15.9(c)-307.4(a)-.9(c)-15.9(i)9.4(d)-316.5([)-15.9(\()]TJ /F7 1 Tf 11.5367 0 TD 0 Tc (E)Tj /F6 1 Tf .599 0 TD -.0158 Tc [(\)-)-15.8(9)10.8(-oc)-15.8(t)9.5(a)-.8(dec)-15.8(e)8.5(noic)-323.3(aci)-15.8(d)10.7(])-316.4(a)-15.8(n)9.6(d)-316.4(t)-15.8(r)10.7(e)-.8(-)]TJ -12.1357 -1.1116 TD 0 Tc [(ha)25.4(l)16.1(o)16.2(se)-613.7(\()]TJ /F9 1 Tf 3.4385 0 TD (a)Tj /F6 1 Tf .5357 0 TD (-)Tj /F11 1 Tf .3168 0 TD (d)Tj /F6 1 Tf .5357 0 TD -.0162 Tc [(-)-16.2(g)10.4(luc)-16.2(o)9.2(pyr)-16.2(a)9.3(nos)-16.2(y)10.6(l)-.1(-\()-16.2(1)]TJ /F16 1 Tf 7.5279 0 TD 0 Tc (4)Tj /F6 1 Tf 1.2959 0 TD -.0162 Tc [(1\))-16.2(-)]TJ /F9 1 Tf 1.1231 0 TD 0 Tc (a)Tj /F6 1 Tf .5357 0 TD (-)Tj /F11 1 Tf .3168 0 TD (d)Tj /F6 1 Tf .5414 0 TD -.0161 Tc [(-glu)-16.1(c)9.3(opy)-16.1(r)10.5(a)-1.1(nos)-16.1(e)9.5(\))-645(are)]TJ -16.1675 -1.1174 TD .2494 Tc [(p)249.4(r)276(o)265.6(v)265.6(i)249.4(d)275.9(e)264.4(di)265.5(nF)265.7(i)265.5(g)249.4(u)276(r)265.6(e3)265.6(.I)265.6(nF)265.7(i)265.5(g)265.6(u)249.4(r)276(e3)265.6(A\()265.6(h)265.6(i)265.4(g)249.4(h)276(l)265.4(i)265.5(g)265.6(h)249.4(t)275.9(e)264.4(db)265.6(yt)265.4(h)265.6(e)-.5(a)264.4(r)249.4(r)276.1(o)265.6(w)264.7(\))249.4(,)]TJ 0 -1.1116 TD -.016 Tc [(t)-16(h)10.5(e)-283.2(m)-1(ol)-16(e)9.3(c)-1(ul)-16(a)9.3(r)-282(ion)-287.8(for)-287.8(the)-283.2(M)-.7(S)-16(T)9.6(FA-)-16(d)10.6(eriv)-16(a)9.4(t).1(iz)-16(e)8.3(d)-282(ver)-16(s)10.8(ion)-287.8(o).2(f)-282(o)-16(l)10.5(e)-1(ic)]TJ T* [(a)-15.9(c)8.4(id)-212.8(\()-15.9(t)10.6(rim)-15.9(e)8.3(thyl)-15.9(s)10.8(i).1(ly)-15.9(l)-202.5(e)-.9(s)-15.9(t)10.8(er)-212.8(o)-15.9(f)-202.4(ole)-15.9(i)9.4(c)-214(aci)-15.9(d)10.6(,)-215.2(354)-15.9(.)14.1(6)-172.5(g/mol\))-218.5(is)-218.4(obse)-15.9(r)9.6(ved)]TJ 0 -1.1174 TD [(a)-16(t)-376.6(a)-386.9(m)-1(a)-16(s)9.6(s-)-16(t)10.5(o-ch)-16(a)9.4(rge)-392.6(rati)-16(o)-375.4(\()]TJ /F7 1 Tf 10.6843 0 TD -.0153 Tc [(m/)-15.3(z)]TJ /F6 1 Tf 1.342 0 TD 0 Tc [(\))-369.7(o)0(f)-359.3(3)16.2(54)26.6(.)-372(I)16.2(n)-369.7(c)0(o)25.4(m)15(p)16.2(a)15(ri)26.5(s)16.4(o)16.2(n,)-355.9(ma)24.2(s)16.4(s)]TJ -12.0263 -1.1116 TD [(sp)26.8(e)15(c)15(t)0(r)26.5(a)-370.9(fo)26.6(r)-369.7(o)0(l)26.5(e)15(i)16.1(c)-376.6(a)15(c)15(i)16(d)-375.5(o)16.2(b)16.2(t)0(a)25.3(i)16(n)16.2(e)0(d)-360.5(f)16.2(ro)26.6(m)-370.9(c)15(ul)26.5(t)16.1(u)16.2(re)25.5(s)-369.5(g)0(r)26.6(o)16.2(w)15.3(n)-375.5(o)16.2(n)]TJ 7.3823 0 0 6.5614 535.4077 455.5274 Tm -.0239 Tc (13)Tj 9.843 0 0 9.843 542.4943 451.1621 Tm -.0152 Tc (C-)Tj -23.3095 -1.1116 TD -.0157 Tc [(l)-15.7(a)9.6(bel)-15.7(e)9.6(d)-189.6(e)-.7(tha)-15.7(n)9.7(ol)-189.7(yi)-15.7(e)9.6(l).4(ded)-189.6(a)-190.8(mo)-15.7(l)10.8(ecu)-15.7(l)10.8(a)-.7(r)-189.6(i).4(on)-195.3(at)-189.7(372)]TJ /F7 1 Tf 17.7341 0 TD -.0153 Tc [(m/)-15.3(z)]TJ /F6 1 Tf 1.342 0 TD 0 Tc [(,)-176.2(r)16.2(e)15(p)16.2(re)25.5(s)16.4(e)15(nt)26.5(i)16.1(n)16.2(g)]TJ -19.0761 -1.1116 TD [(a)-336.3(g)16.2(ai)25.3(n)-329.4(o)0(f)-319(1)0(8)-319(m)15(as)25.6(s)-335(u)16.2(n)16.2(i)16(ts)26.7(,)-331.7(c)15(on)26.6(s)16.4(i)16.1(st)26.7(e)15(n)16.2(t)-335.3(w)15.3(it)26.3(h)]TJ 7.3823 0 0 6.5614 473.4991 433.644 Tm -.0239 Tc (13)Tj 9.843 0 0 9.843 480.5857 429.2786 Tm -.0159 Tc [(C)-346.3(i)-15.9(n)10.6(c)-.9(or)-15.9(p)10.7(ora)-15.9(t)9.4(i).2(on)-351.1(at)]TJ -17.0199 -1.1174 TD [(e)-15.9(a)8.4(ch)-270.4(of)-270.4(th)-15.9(e)-261.2(1).3(8)-270.4(carb)-15.9(o)10.7(ns)-270.2(of)-270.4(o)-15.9(l)10.6(eic)-271.6(a)-.9(c)-15.9(i)9.4(d)-270.4(\(18:)-15.9(1)]TJ /F9 1 Tf 7.3823 0 0 6.5614 473.0455 422.6456 Tm 0 Tc (D)Tj /F6 1 Tf .6451 0 TD (9)Tj 9.843 0 0 9.843 481.3794 418.2802 Tm -.0159 Tc [(\).)-272.8(For)-270.4(t)-15.9(r)10.6(e)-.9(hal)-15.9(o)10.6(se,)-272.8(i).2(n)]TJ -17.1006 -1.1116 TD 0 Tc [(Fi)26.6(g)16.2(u)16.2(r)0(e)-170.4(3)0(B)25.6(,)-182(t)16.1(h)16.2(e)-186.6(f)16.2(ra)25.5(g)16.2(m)15(e)15(n)16.2(t)-185.5(i)16.1(on)-169.2(a)15(t)-185.5(3)16.2(6)0(1)]TJ /F7 1 Tf 13.3683 0 TD -.0153 Tc [(m/)-15.3(z)]TJ /F6 1 Tf 1.5378 0 TD -.0158 Tc [(r)-15.8(e)9.7(pre)-15.8(s)9.8(e)-.8(nt)-15.8(e)9.5(d)-195.4(a)-202.4(s).6(i)-15.8(x)10.7(-car)-15.8(b)10.8(o).4(n)]TJ -14.9061 -1.1116 TD -.016 Tc [(p)-16(r)10.6(odu)-16(c)9.4(t)-282.2(resu)-16(l)10.5(tin)-16(g)-265.9(f)-16(r)10.7(o).2(m)-283.3(s).4(ci)-16(s)10.7(s).4(i)-16(o)10.5(n)-282(a)-1(t)-282.2(t).1(he)-283.2(gly)-16(c)9.4(osid)-16(i)10.5(c)-283.2(bond)-282(to)-282(y)-16(i)10.5(eld)]TJ 0 -1.1174 TD 0 Tc [(tw)25.6(o)-300.6(i)0(d)26.5(e)15(n)16.2(t)16(ic)25.3(a)15(l)-300.7(fr)26.7(a)15(g)16.2(m)15(e)0(n)25.4(t)-300.7(i)16.1(o)0(n)26.6(s)-300.4(\(F)26.8(u)]TJ 12.1184 .0115 TD ()Tj .3974 -.0115 TD -.015 Tc [(zf)-15(a)10.5(i)]TJ /F7 1 Tf 1.7682 0 TD -.0156 Tc [(et)-322.1(al.)]TJ /F6 1 Tf 2.0044 0 TD -.016 Tc [(,)-318.9(200)-16(8)10.6(\)).2(.)-318.9(I).2(n)-322.4(c)-1(ompa)-16(r)9.5(i)0(-)]TJ -16.2885 -1.1116 TD [(s)-15.9(o)10.9(n,)-226.7(mass)-224.2(s).5(pe)-15.9(c)8.4(t).2(ra)-225.5(of)-224.3(tre)-15.9(h)9.5(alo)-15.9(s)10.9(e)-219.7(o)-15.9(b)10.7(t).2(ai)-15.9(n)10.6(e)-.9(d)-224.3(from)-225.6(cul)-15.9(t)10.4(ure)-15.9(s)-209.1(g)-15.9(r)10.7(o).3(wn)-224.3(on)]TJ 7.3823 0 0 6.5614 313.0582 367.8802 Tm -.0162 Tc (13)Tj 9.843 0 0 9.843 320.2015 363.5149 Tm -.0158 Tc [(C-la)-15.8(b)9.6(e)-.8(led)-374(e)-.8(th)-15.8(a)9.6(nol)-374.1(yiel)-15.8(d)10.7(e)-.8(d)-374(a)-369.4(fr)-15.8(a)9.7(g).4(ment)-374.1(i).3(on)-374(pea)-15.8(k)-359(at)-374.1(367)]TJ /F7 1 Tf 21.979 0 TD (m/z)Tj /F6 1 Tf 1.342 0 TD 0 Tc (,)Tj -24.0468 -1.1174 TD -.016 Tc [(r)-16(e)9.5(pre)-16(s)9.6(e)-1(nt)-16(i)10.3(n).2(g)-282(a)-277.4(g)-16(a)9.4(in)-282(of)-282(6)-282(mass)-281.9(uni)-16(t)10.3(s).4(,)-284.4(c)-1(ons)-16(i)10.7(s).4(te)-16(n)9.4(t)-282.2(with)]TJ 7.3823 0 0 6.5614 513.0707 356.9385 Tm -.0162 Tc (13)Tj 9.843 0 0 9.843 520.1573 352.5164 Tm .2671 Tc [(Ci)283.1(n)283.3(c)267.1(o)292.5(r)283.3(-)]TJ -21.0402 -1.1116 TD -.0158 Tc [(p)-15.8(o)10.8(rat)-15.8(i)10.5(on)-270.3(at)-270.5(e)-15.8(a)8.5(ch)-270.3(of)-276.1(the)-271.5(car)-15.8(b)10.8(ons)-275.9(in)-270.3(the)-271.5(f)-15.8(r)10.9(a)-.8(gme)-15.8(n)9.6(t)-270.5(i).2(on)-15.8(s)11(.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 313.0582 319.6913 Tm 0 Tc [(3.4.)-502.8(Kinetics)-338.4(of)-330.4(ethanol)-332.4(and)-335.7(2-propanol)-335.6(oxidation)]TJ /F6 1 Tf 9.843 0 0 9.843 323.0361 303.2503 Tm [(The)-218.8(alc)11.5(oho)19.7(l)-225.9(deh)12.8(ydr)14(oge)12.8(nas)13(e)-226.9(a)0(c)12.8(tiv)13.7(iti)13.6(es)-222(in)-221.2(cel)11.5(lul)13.7(ar)-222.2(ex)13.9(tra)12.7(cts)-217.5(of)]TJ /F7 1 Tf -1.0137 -1.1174 TD [(A.)-305.2(rad)14.2(ior)14(esi)12.9(ste)12.9(ns)]TJ /F6 1 Tf 7.0844 0 TD [(50v)14(1)-306.4(wer)12(e)-313.3(m)0(e)12.7(asu)13(red)-303.9(ag)13.9(ain)12.7(st)-307.4(the)-298.3(sub)14.2(str)14.1(ate)11.5(s)]TJ -7.0844 -1.1116 TD [(of)-376.5(et)13.8(han)12.8(ol)-370.9(and)-367.3(2-p)14(rop)14(ano)12.8(l)-375.6(\(Fi)14(g.)-367.4(4\).)-368.5(Cul)12.8(tur)13.9(es)-371.8(wer)12(e)-376.6(pre)18.6(par)12.8(ed)]TJ T* [(und)14(er)-308.6(ul)14.9(tra)12.7(min)12.6(ima)11.5(l)-306.5(con)12.8(dit)13.7(io)15(ns)-307.3(\(0.)17.4(2)]TJ /F8 1 Tf 14.1919 0 TD ()Tj /F6 1 Tf .7142 0 TD [(M9,)-300.3(26)]TJ /F9 1 Tf 3.0872 0 TD (m)Tj /F6 1 Tf .5472 0 TD .313 Tc [(MF)313(e)]TJ 7.3823 0 0 6.5614 517.0392 274.3369 Tm 0 Tc (2)Tj /F8 1 Tf .4992 0 TD (+)Tj /F6 1 Tf 9.843 0 0 9.843 524.7495 270.3684 Tm [(\))-306.3(usi)14(ng)]TJ -21.5067 -1.1174 TD [(16)-157.7(mM)-280.8(eth)12.7(ano)12.8(l)-283.5(a)0(s)-285.4(the)-275.3(sol)14(e)-284.5(car)11.7(bon)-274(sou)14.2(rce)11.7(.)-285.6(Ext)12.7(rac)11.7(ts)-278.6(wer)12(e)-284.5(pre)12.8(-)]TJ 0 -1.1116 TD [(par)12.8(ed)-475.7(by)-468.7(ult)13.7(ras)13(oni)13.8(cat)17.3(ion)13.9(,)-475.7(and)-471(the)-465.4(mem)16.1(bra)12.8(ne)-475.7(\(re)18.6(susp)19(end)12.8(ed)]TJ T* [(pel)12.7(let)12.6(\))-461.8(and)-459.5(sol)14(ub)15.1(le)-464.3(\(su)14.2(per)12.8(na)13.9(tan)12.7(t\))-463.1(fra)18.6(cti)12.6(ons)-458.1(we)13(re)-464.1(sep)13(ar)14(ate)11.5(ly)]TJ 0 -1.1174 TD [(tes)12.9(ted)-425(for)-423.7(alc)11.5(oh)15.1(ol)-428.5(oxi)13.8(dat)12.7(ion)-418.1(act)11.5(ivi)13.7(tie)12.6(s.)-424.8(Com)11.7(par)12.8(iso)14(ns)-428.2(of)-422.6(the)]TJ 0 -1.1116 TD [(pro)14(tei)12.6(n)-335.2(ext)12.7(rac)11.7(ts)-324.7(rev)12.8(eal)11.5(ed)-325.9(app)12.8(rox)14(ima)11.5(tel)12.6(y)-329.4(ve)13(fol)13.9(d)-335.2(hig)13.9(he)13.9(r)-335.1(spe)13(-)]TJ T* [(ci)12.9(c)-486.1(act)11.5(ivi)13.7(tie)12.6(s)-484.7(i)0(n)-480.4(the)-471.1(mem)10.4(bra)12.8(ne)-481.4(fra)18.6(cti)12.6(ons)14.2(.)-487.2(Kin)13(et)13.8(ic)-481.5(stu)14(die)12.7(s)]TJ 0 -1.1174 TD [(on)-278.7(the)-275.3(mem)10.4(bra)12.8(ne)-274.1(fra)12.9(cti)12.6(ons)-273.8(usi)14(ng)-278.7(the)-275.3(sub)14.2(str)14.1(ate)11.5(s)-283.1(o)0(f)-278.6(e)0(t)13.8(han)12.8(ol)-278.8(or)]TJ 0 -1.1116 TD 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9.843 0 0 9.843 406.8849 429.6755 Tm .0073 Tc [(,)-474.2(1).4(6)-172.3(m)-.8(M)-478.5(e)-.7(t)-5.4(h).4(a)-6.5(n).4(o)-5.3(l).3(,)-474.2(a)-6.5(nd)-477.6(no)-477.6(ba)-6.5(ct)-5.5(er)-5.3(i)-5.4(a)]TJ -9.7569 -1.1116 TD .0122 Tc [(\()5.4(S)-.3(up)5.3(pl)5.2(emen)5.3(tary)-328.7(Fi)5.2(g.)-331.1(S2)5.3(D,)-331.1(E\).)]TJ 1.0137 -1.1116 TD 0 Tc [(Co)19.8(mp)19.6(ar)19.7(is)20.9(on)-295.9(of)-290.1(th)15(e)-301.8(d)0(a)19.7(t)0(a)-297.2(\()]TJ /F7 1 Tf 10.1889 0 TD (p)Tj /F8 1 Tf .6566 0 TD (<)Tj /F6 1 Tf .7084 0 TD [(0.)18.5(01)20.8(71)20.8(,)]TJ /F7 1 Tf 3.2427 0 TD (t)Tj /F6 1 Tf .2707 0 TD [(-t)20.7(es)14.1(t,)-292.6(fa)19.7(ls)20.9(e)-307.5(d)0(i)20.7(s)0(c)19.9(o)0(v)20.8(e)0(r)19.7(y)]TJ -16.0811 -1.1174 TD [(ra)19.7(te)-228.1(of)-226.8(0.)18.5(10)20.8(\))-243(s)0(u)21(p)0(p)20.8(o)0(r)20.9(t)0(e)19.6(d)-243(th)20.7(e)-238.4(f)0(o)20.9(r)0(m)19.6(a)0(t)19.5(i)0(o)15(n)-237.2(of)-226.8(de)19.7(gr)20.9(ad)13.9(at)19.5(io)20.7(n)-237.2(p)0(r)20.9(o)0(d)20.8(u)0(c)13.9(t)0(s)20.9(,)]TJ 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[(et)19.5(hy)20.8(le)13.8(ne)-372(gl)20.7(yc)19.7(ol)-370.9(mo)19.6(no)20.8(bu)15.1(ty)20.7(l)-381.4(e)0(t)19.5(h)0(e)19.7(r)0(,)-373.1(1)0()20.8(5)0(%)-371.9(n)0(o)20.8(n)0(y)15.1(l)0(p)20.7(h)0(e)19.7(n)0(o)20.8(l)-381.4(et)19.5(ho)15.1(x-)]TJ 0 -1.1116 TD [(yl)20.7(at)19.5(e,)-437.7(1%)-441(do)20.8(de)19.7(cy)19.7(lb)20.7(en)19.7(ze)18.5(ne)13.9(su)21(lf)20.7(on)20.8(at)19.5(e,)-437.7(an)19.7(d)-450.3(1)0()20.8(4)0(%)-435.2(s)0(i)20.9(l)0(i)14.8(c)0(i)19.5(c)-445.8(ac)18.5(id)20.7(,)]TJ T* [(di)20.7(so)15.3(di)20.7(um)-314.4(sa)19.9(lt)20.6(.)]TJ 1.0137 -1.1174 TD .0198 Tc [(As)-660.7(summa)-5.5(riz)-5.5(e).3(d)-660.9(i)1.3(n)-666.7(F)1.6(igure)-662.1(5)-4.3(B,)-663.3(impacts)-666.5(t)1.3(o)-660.9(t)-4.5(he)-662.1(ex-)]TJ -1.0137 -1.1116 TD .0202 Tc [(trace)-5.1(llular)-464.7(m).6(e)-5.1(t)1.7(abolome)-471.6(w)1(ere)-465.9(s)2(upported)-464.7(b)-3.9(y)-464.7(d)1.8(ec)-5.1(rea)-5.1(s)2(es)-464.5(in)]TJ T* .0188 Tc [(ab)-5.3(und)-5.3(ance)-6.5(s)-275.8(f)-5.3(or)-281.8(sev)-5.3(e)-.7(ra)-6.5(l)-276.2(h)-5.3(ydr)-5.3(oxy-)-281.8(an)-5.3(d)-276(k)-5.3(eto)-5.3(acid)-5.3(s).6(,)-278.4(i)-5.5(ncl)-5.5(udi)-5.5(ng)]TJ 0 -1.1174 TD [(2-)-5.3(ket)-5.5(oglu)-5.3(t).3(ar)-5.3(ate)-6.5(,)]TJ /F9 1 Tf 7.4243 0 TD 0 Tc (a)Tj /F6 1 Tf .5702 0 TD .0188 Tc [(-)-5.3(hyd)-5.3(rox)-5.3(ygl)-5.5(utar)-5.3(ate)-6.5(,)-767.9(2-)-5.3(ket)-5.5(o).4(is)-5.1(ocap)-5.3(roa)-6.5(t).3(e,)]TJ -7.9945 -1.1116 TD [(ci)-5.6(tra)-6.6(t).2(e,)-290(and)-287.7(4)-5.4(-hyd)-5.4(rox)-5.4(yph)-5.4(enyl)-5.6(lac)-6.6(t).2(ate)-6.6(.)-284.2(F)-5.3(u).3(rt)-5.6(herm)-6.7(ore,)-290(co)-5.4(ntro)-5.4(l)]TJ T* .0205 Tc [(experiments)-423.9(w)1.3(ith)-424.1(K)1.3(leenol)-424.2(30)-424.1(\(Fig.)-426.4(5)2.1(A)-4.5(\))-424.1(showed)-424.1(that)-424.2(in-)]TJ 0 -1.1174 TD .0187 Tc [(cu)-5.4(bati)-5.6(ons)-299(in)-293.4(0)-5.4(.)3.8(2)]TJ /F8 1 Tf 6.9116 0 TD 0 Tc ()Tj /F6 1 Tf .7372 0 TD .0188 Tc [(M9)-293.3(\()-5.3(c)-.7(on)-5.3(tai)-5.5(n).4(ing)-299.1(2).4(6)]TJ /F9 1 Tf 8.0118 0 TD 0 Tc (m)Tj /F6 1 Tf .576 0 TD .313 Tc [(MF)294.8(e)]TJ 7.3823 0 0 6.5614 243.8362 115.8235 Tm 0 Tc (2)Tj /F8 1 Tf .5299 0 TD (+)Tj /F6 1 Tf 9.843 0 0 9.843 254.8913 111.4016 Tm .0253 Tc [(an)6.9(d)-286.8(1)1.2(6)-160.1(m)5.7(M)]TJ -19.5945 -1.1116 TD .0189 Tc [(et)-5.4(hano)-5.2(l\),)-249.5(i)-5.4(n)-247.1(t).4(h)-5.2(e)-248.3(ab)-5.2(sen)-5.2(c)-.6(e)-248.3(o)-5.2(f)]TJ /F7 1 Tf 11.266 0 TD [(A.)-249.6(r)-5.1(adi)-5.5(ores)-5.1(is)-5.1(tens)]TJ /F6 1 Tf 7.3494 0 TD .0185 Tc [(50)-5.6(v1,)-249.9(yi)-5.8(eld)-5.6(e)-1(d)]TJ -18.6154 -1.1116 TD .0188 Tc [(su)-5.3(bst)-5.5(a)-.7(nt)-5.5(ial)-650.6(i).3(nc)-6.5(reas)-5.1(es)-650.2(in)-650.4(the)-651.6(a)-.7(bun)-5.3(dan)-5.3(ces)-650.2(of)-650.4(deca)-6.5(noat)-5.5(e)]TJ T* [(\(1)-5.3(0:0)-5.3(\)).5(.)-554.8(H)-6.2(owev)-5.3(er,)-560.6(i).3(n)-558.3(t).3(he)-559.4(pr)-5.3(ese)-6.5(n).4(ce)-559.4(of)]TJ /F7 1 Tf 16.9047 0 TD [(A.)-554.9(r)-5.2(adi)-5.6(ore)-6.6(s).5(is)-5.2(ten)-5.4(s)]TJ /F6 1 Tf -16.9047 -1.1174 TD [(50)-5.3(v1,)-347.5(d)-5.3(eca)-6.5(noat)-5.5(e)-346.3(w)-6.2(a)-.7(s)-350.7(not)-351(det)-5.5(ecte)-6.5(d).4(,)-347.5(s)-5.1(ugg)-5.3(esti)-5.5(ng)-350.9(eit)-5.5(h).4(er)-350.9(bio)-5.3(-)]TJ 0 -1.1116 TD .0186 Tc [(de)-6.7(gra)-6.7(d).2(ati)-5.7(o).2(n)-333.8(o).2(r)-339.6(m)-1(eta)-6.7(boli)-5.7(s).4(m)-335.1(o).2(f)-339.6(t).1(his)-339.4(p).2(ro)-5.5(duct)-5.7(.)]TJ /F5 1 Tf 8.9663 0 0 8.9663 313.0582 364.1385 Tm 0 Tc [(4.)-501.1(Discussion)]TJ /F6 1 Tf 9.843 0 0 9.843 323.0361 341.5747 Tm [(In)-267.1(this)-263.7(study,)-268.1(we)-263.4(measured)-266.7(the)-269.5(ability)-262.8(of)-267.1(several)-264.5(strains)-267.9(of)]TJ -1.0137 -1.1174 TD (spacecraft-associated)Tj /F7 1 Tf 9.0312 0 TD (Acinetobacter)Tj /F6 1 Tf 6.1283 0 TD [(to)-497.7(metabolize)-501.1(or)-497.5(bio-)]TJ -15.1595 -1.1116 TD [(degrade)-351(the)-344.4(reagents)-346.3(used)-345.2(to)-342.1(clean)-348.9(spacecraft,)-348.4(and)-344.3(surfaces)]TJ T* [(and)-367.3(oors)-362.2(of)-359.3(spacecraft)-368(assembly)-363.4(facilities.)-369.7(Cultivations)-361.5(in)]TJ 0 -1.1174 TD [(the)-304.1(presence)-301.2(of)-295.9(the)-298.3(cleaning)-306.3(reagents)-300.2(were)-301.3(conducted)-301.5(under)]TJ 0 -1.1116 TD [(ultraminimal)-496.7(conditions)-490.4(to)-491.9(roughly)-491.6(approximate)-489.4(the)-494.2(low-)]TJ T* [(nutrient)-367.4(and)-361.6(low-particulate)-368.2(\(inorganics)-365.8(and)-361.6(organics\))-363.5(con-)]TJ 0 -1.1174 TD [(ditions)-514.8(of)-514.8(the)-511.4(assembly)-513.2(facilities.)-519.4(Cultivations)-517(were)-514.4(per-)]TJ 0 -1.1116 TD [(forme)-7.8(d)-513.7(i)0(n)-514.9(0.2)]TJ /F8 1 Tf 6.1283 0 TD ()Tj /F6 1 Tf .72 0 TD [(M9)-515.7(minimal)-518.6(medium)-517.2(supplemented)-519.1(with)]TJ -6.8483 -1.1116 TD (26)Tj /F9 1 Tf 1.1692 0 TD (m)Tj /F6 1 Tf .5529 0 TD .2381 Tc [(MF)238.1(e)]TJ 7.3823 0 0 6.5614 350.929 247.2944 Tm 0 Tc (2)Tj /F8 1 Tf .4992 0 TD (+)Tj /F6 1 Tf 9.843 0 0 9.843 358.696 242.929 Tm [(,)-239.6(where)-244.8(alkali,)-243.1(halogen,)-238.2(and)-240.6(main)-243.1(group)-241.6(elements)]TJ -4.6366 -1.1116 TD (\()Tj /F7 1 Tf .3283 0 TD [(i.)24.1(e.)]TJ /F6 1 Tf 1.1865 0 TD [(,)-366.3(N)0(,)-356.7(S)0(,)-361.5(a)0(n)19.7(d)-364(P,)-361.5(ex)19.7(cl)19.6(ud)20.8(in)20.7(g)-369.7(o)0(x)20.8(y)0(g)20.8(e)0(n)19.7(\))-369.7(we)18.8(re)]TJ /F8 1 Tf 16.179 0 TD (<)Tj /F6 1 Tf .5414 0 TD [(15)-146.2(mM)-355.7(in)-359.4(co)19.7(n-)]TJ -18.2352 -1.1174 TD [(ce)12.8(nt)20.7(ra)19.7(ti)20.6(on)20.8(,)-452.7(a)0(l)19.5(k)0(a)19.7(l)0(i)14.8(n)0(e)-441.1(e)0(a)18.5(r)0(t)20.7(h)-450.4(me)18.4(ta)19.5(ls)-445.6(we)18.8(re)]TJ /F8 1 Tf 16.012 0 TD ()Tj /F6 1 Tf .5414 0 TD [(0.)18.5(4)]TJ /F9 1 Tf 1.3881 0 TD (m)Tj /F6 1 Tf .5414 0 TD [(M,)-443.2(an)19.7(d)-450.4(h)0(e)19.7(a)0(v)19.7(y)]TJ -18.4829 -1.1116 TD [(me)18.4(ta)13.8(ls)-388(co)13.9(nt)20.7(am)18.5(in)20.7(an)19.7(ts)-393.8(we)18.8(re)-395(co)19.7(ll)20.6(ec)18.5(ti)20.6(ve)19.7(ly)]TJ /F8 1 Tf 15.9371 0 TD ()Tj /F6 1 Tf .5414 0 TD [(0.)18.5(00)20.8(1%)-394.9(of)-388.1(th)14.9(e)-399.7(m)0(e)18.4(-)]TJ -16.4785 -1.1116 TD [(di)14.9(um)-562.1(co)13.9(ns)21(ti)20.6(tu)20.7(en)19.7(ts)15.1(.)-573.6(I)0(n)-566.6(c)0(o)19.7(m)0(p)19.6(a)0(r)19.7(i)0(s)15.1(o)0(n)-566.6(w)0(i)19.8(t)0(h)-566.8(p)0(r)20.9(i)0(o)20.7(r)-577(wo)20(rk)20.9(,)-579.4(e)0(a)18.5(r)0(l)20.7(y)]TJ 0 -1.1174 TD [(cu)13.9(lt)20.6(iv)20.7(at)19.5(io)20.7(ns)-572.2(of)-572.4(th)20.7(e)]TJ /F7 1 Tf 8.3573 0 TD [(Ac)18.5(in)20.7(et)19.5(ob)20.8(ac)19.7(te)19.6(r)]TJ /F6 1 Tf 6.0938 0 TD [(on)-572.4(et)19.5(ha)19.7(no)20.8(l)-583(r)0(e)19.7(l)0(i)20.6(e)0(d)-573.6(u)0(p)20.8(o)0(n)]TJ -14.4511 -1.1116 TD [(in)15(or)20.9(ga)19.7(ni)20.7(c-)19.7(ri)15(ch)-498.7(me)18.4(di)20.7(um)-504.5(\(A)20(bb)20.8(ot)20.7(t)]TJ /F7 1 Tf 13.3913 0 TD [(et)-498.8(al)20.7(.)]TJ /F6 1 Tf 2.229 0 TD [(,)-510.3(1)0(9)20.8(7)0(3)20.8(\))-513.7(co)19.7(nt)20.7(ai)19.6(ni)14.9(ng)-497.5(a)]TJ -15.6203 -1.1116 TD [(va)13.9(ri)20.7(et)19.5(y)-577.1(o)0(f)-572.4(s)0(u)21(p)0(p)20.8(l)0(e)19.6(m)0(e)18.4(n)0(t)20.7(e)0(d)-567.8(m)0(e)18.4(t)0(a)13.8(l)0(l)20.6(o)0(i)20.7(d)0(s)-566.5(a)0(n)13.9(d)-577.1(tr)20.7(an)19.7(si)20.9(ti)14.8(on)-566.6(me)18.4(ta)19.6(ls)]TJ 0 -1.1174 TD (\()Tj /F7 1 Tf .3283 0 TD [(e.)23.1(g.)]TJ /F6 1 Tf 1.4054 0 TD .2684 Tc [(,0)268.4(.)292.7(1)268.4()283.5(1)268.4(0)289.2(0)]TJ /F9 1 Tf 3.8648 0 TD 0 Tc (m)Tj /F6 1 Tf .5414 0 TD [(M)-266.9(c)0(o)19.7(n)0(c)19.7(e)0(n)19.7(t)0(r)20.7(a)0(t)19.6(i)0(o)15(n)0(s)-255.4(o)0(f)-255.6(F)0(e)19.8(,)-262.6(Mn)19.9(,)-268.4(C)0(u)19.8(,)-262.6(Co)14(,)-262.6(Z)0(n)19.6(,)-268.4(Mo)19.9(,)]TJ -6.1398 -1.1116 TD [(an)13.9(d)-507.9(B)0(\))14.1(,)-510.3(wi)19.8(th)-503.4(ot)20.7(he)19.7(r)-513.7(m)0(e)18.4(d)0(i)20.7(a)-514.9(co)19.7(nt)20.7(ai)19.5(ni)20.7(ng)-503.3(or)20.9(ga)13.9(ni)20.7(c)-509.1(c)0(o)13.9(m)0(p)19.6(o)0(n)20.8(e)0(n)19.7(t)0(s)]TJ T* [(su)15.3(ch)-343.2(as)-348.8(ci)19.5(tr)20.7(at)19.6(e)-353.6(\()0(D)14.2(u)-352.4(Pr)21(ee)18.5(z)]TJ /F7 1 Tf 10.5863 0 TD [(et)-343.3(al)20.7(.)]TJ /F6 1 Tf 2.0735 0 TD [(,)-354.8(1)0(9)20.8(8)0(1)20.8(\))0(,)-344.3(a)0(n)19.7(d)-358.2(ye)19.7(as)19.9(t)-352.6(a)0(u)19.7(t)0(o)14.9(l)0(y)20.7(s)0(a)19.9(t)0(e)]TJ -12.6598 -1.1174 TD [(an)13.9(d)-323.6(p)0(a)19.7(n)0(t)20.7(o)0(t)20.7(h)0(e)19.7(n)0(a)19.7(t)0(e)-314.5(\()0(P)15.3(i)0(r)20.7(o)0(g)-313.2(a)0(n)19.7(d)-323.6(Ku)20(z)19.7(mi)19.5(ns)15.3(ka)19.7(ya)19.7(,)-320.2(2)0(0)20.8(0)0(3)15.1(\))0(.)]TJ 1.0137 -1.1116 TD -.0281 Tc [(Un)5.4(der)-305.6(m)-1.6(o)5.4(r)-.4(e)-312.6(e)4.2(xt)5.2(reme)-312.6(n)5.4(u)-.4(t)5.2(r)-.4(ient-)5.4(r)-.4(es)5.6(tri)5.2(c)-1.6(t)5.2(e)-1.6(d)-311.4(c)4.2(on)5.4(dit)5.2(i)-.5(o)5.4(n)-.4(s)-311.2(\()5.4(0.2)]TJ /F8 1 Tf 21.0172 0 TD 0 Tc ()Tj /F6 1 Tf .6854 0 TD -.0273 Tc (M9,)Tj -22.7163 -1.1116 TD 0 Tc (26)Tj /F9 1 Tf 1.1519 0 TD (m)Tj /F6 1 Tf .5414 0 TD .3245 Tc [(MF)324.5(e)]TJ 7.3823 0 0 6.5614 351.2692 104.8252 Tm 0 Tc (2)Tj /F8 1 Tf .4838 0 TD (+)Tj /F6 1 Tf 9.843 0 0 9.843 358.866 100.4598 Tm [(\),)-309.8(mo)19.6(st)-313.2(of)-313.2(th)20.7(e)-324.8(t)0(e)19.6(s)0(t)15.1(e)0(d)-314.4(s)0(p)21(a)0(c)18.5(e)0(c)18.5(r)0(a)19.7(f)0(t)15(-)0(a)19.7(s)0(s)21.2(o)0(c)19.7(i)0(a)19.6(t)0(e)13.8(d)-317.9(st)15.1(ra)19.7(in)20.7(s)]TJ -4.6538 -1.1116 TD [(gr)15.1(ew)-269.2(on)-267.1(et)19.6(ha)19.7(no)20.8(l)-277.7(a)0(s)-268.1(a)-278.7(so)21(le)-268.4(ca)18.5(rb)15.1(on)-267.1(so)21(ur)20.9(ce)-269.5(\(s)21.1(ix)-273(ou)20.8(t)-277.7(o)0(f)-267.1(t)0(h)20.7(e)-278.7(se)19.9(ve)19.7(n)]TJ 0 -1.1174 TD [(te)13.8(st)20.9(ed)-274.1(st)20.9(ra)19.7(in)20.7(s\))15.3(.)-279.9(C)0(u)19.8(l)0(t)14.8(i)0(v)20.7(a)0(t)19.5(i)0(o)20.7(n)0(s)-272.7(p)0(r)20.9(o)0(v)15.1(i)0(d)20.7(e)0(d)-274.1(h)0(i)20.7(g)0(h)-272.9(c)0(e)18.5(l)0(l)-273.2(c)0(o)19.7(u)0(n)20.8(t)0(s)-272.8(a)0(t)-274.2(m)0(i)19.5(d)0(-)]TJ 0 -1.1116 TD [(lo)15(g)-565.6(p)0(h)20.8(a)0(s)19.9(e)-566.7(\(1)20.9(0)]TJ 7.3823 0 0 6.5614 371.5085 71.9433 Tm (8)Tj 9.843 0 0 9.843 375.1369 67.5779 Tm [(1)20.8(0)]TJ 7.3823 0 0 6.5614 389.5936 71.9433 Tm (9)Tj 9.843 0 0 9.843 398.8912 67.5779 Tm [(cf)19.7(u/)20.7(mL)18.4(\),)-557.4(wh)20(er)19.7(e)-566.7(g)0(e)19.7(n)0(e)19.7(r)0(a)19.7(t)0(i)14.8(o)0(n)-555.1(t)0(i)20.6(m)0(e)18.4(s)-565.4(\(o)20.9(r)]TJ -8.7202 -1.1116 TD [(do)15.1(ub)20.8(li)20.6(ng)-313.2(ti)20.6(me)18.4(s\))-318.8(ra)19.7(ng)20.8(ed)-314.4(fr)15.2(om)-314.4(0.)24.3(56)-319(to)-313.4(0.)18.5(80)-146.2(h)-323.6(i)0(n)-313.4(1)0(6)-146.2(m)0(M)-315.4(\()0(0)15.1(.)13.9(1%)]TJ ET q 490.48 0 0 221.726 62.022 507.515 cm /Im5 Do Q BT /F10 1 Tf 9.845 0 0 9.845 62.022 493.2282 Tm [(FIG.)-336.7(5.)]TJ /F6 1 Tf 4.1174 0 TD [(Biodegradation)-341.4(and)-332.4(impacts)-338.9(of)-336(0.1%)-335.6(and)-332.4(1.0%)-335.6(v/v)-337.1(Kleenol)-338.7(30)-336(on)-336(cultures)-332.9(of)]TJ /F7 1 Tf 32.029 0 TD [(A.)-339.5(radioresistens)]TJ /F6 1 Tf 7.2039 0 TD [(50v1)-332.2(\(0.2)]TJ /F8 1 Tf 4.0828 0 TD ()Tj /F6 1 Tf .7198 0 TD (M9,)Tj -48.153 -1.0077 TD (26)Tj /F9 1 Tf 1.169 0 TD (m)Tj /F6 1 Tf .5528 0 TD .2494 Tc [(MF)249.4(e)]TJ 7.3837 0 0 6.5625 99.9496 487.6723 Tm 0 Tc (2)Tj /F8 1 Tf .4991 0 TD (+)Tj /F6 1 Tf 9.845 0 0 9.845 107.7732 483.3069 Tm [(,)-245.2(1)0(6)-169(m)0(M)-251.6(ethanol,)-249.1(32)]TJ /F8 1 Tf 8.0389 0 TD ()Tj /F6 1 Tf .3916 0 TD 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[(prepared)-276.3(from)-275.8(glycerol)-275.5(stocks,)-275.2(and)-274.8(technical)-279(replicates)-274.1(referred)-276.3(to)-278.6(samples)-275.2(cultivated)-273.2(from)-275.8(separate)-277.5(colonies)-275.3(from)-275.8(the)-275(same)]TJ 0 -1.0077 TD [(plate;)-291(all)-292.4(metabolites)-292.5(were)-289.3(detected)-295.1(in)-284.3(three)-295.4(biological)-289.3(replicates)-291.4([)]TJ /F7 1 Tf 26.783 0 TD (n)Tj /F8 1 Tf .668 0 TD (=)Tj /F6 1 Tf .7198 0 TD [(3],)-287.5(with)-287.3(at)-291.3(least)-289.6(one)-292.1(technical)-290.5(replicate)-296.3(per)-286.3(condition,)]TJ -28.1708 -1.0135 TD [(except)-378.2(for)-377.3(citrate)-379.5([)]TJ /F7 1 Tf 7.774 0 TD (n)Tj /F8 1 Tf .668 0 TD (=)Tj /F6 1 Tf .7198 0 TD [(1)-375.3(with)-379.4(three)-376(technical)-382.7(replicates])-384.5(and)-378.4(suberic)-377.8(acid)-375([)]TJ /F7 1 Tf 21.4794 0 TD (n)Tj /F8 1 Tf .668 0 TD (=)Tj /F6 1 Tf .7198 0 TD [(1)-375.3(with)-379.4(two)-378.3(technical)-376.9(replicates];)-385.6(error)-380.4(bars)]TJ 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[(su)15.3(pp)20.8(or)20.9(t)-387.1(a)-388.2(tr)20.7(en)19.7(d)-387(b)0(e)19.7(t)0(w)14.1(e)0(e)18.5(n)-387(lo)20.7(we)18.8(r)-387(o)0(p)20.8(t)0(i)20.6(m)0(a)18.4(l)-387.1(su)15.3(bs)21(tr)20.7(at)19.5(e)-388.2(c)0(o)19.7(n)0(c)13.9(e)0(n)19.7(t)0(r)20.7(a)0(-)]TJ 0 -1.1116 TD [(ti)14.8(on)20.8(s)-288.9(a)0(n)19.7(d)-289.1(sp)21(ac)18.5(ec)18.5(ra)19.7(ft)-278.8(as)19.9(so)15.3(ci)19.6(at)19.5(io)20.7(n,)-281(wh)20(ic)19.6(h)-289.1(w)0(o)20(u)0(l)20.7(d)-289.1(be)-279.8(a)-284.5(n)0(e)19.7(c)0(e)12.8(s)0(s)21.2(a)0(r)19.7(y)]TJ T* [(co)13.9(rr)20.9(el)19.5(at)19.5(io)20.7(n)-433.1(f)0(o)15.1(r)-433(an)19.7(y)-433.1(p)0(o)20.8(s)0(t)20.9(u)0(l)20.7(a)0(t)19.5(e)0(d)-429.6(m)15(et)13.8(ab)19.7(ol)20.7(is)20.9(m)-434.3(u)0(n)20.8(d)0(e)19.7(r)-433(th)15(e)-434.2(o)0(l)20.7(i)0(g)20.7(o)0(-)]TJ 0 -1.1174 TD [(tr)15(op)20.8(hi)20.7(c)-324.8(c)0(o)19.7(n)0(d)20.8(i)0(t)20.6(i)0(o)15(n)0(s)-313(o)0(f)-313.2(t)0(h)20.7(e)-324.8(as)19.9(se)19.9(mb)19.6(ly)-313.3(fa)19.7(ci)13.8(li)20.6(ti)20.6(es)19.9(.)]TJ 1.0137 -1.1116 TD [(Fo)21(r)-513.7(t)0(h)20.7(i)0(s)-509(s)0(t)20.9(u)0(d)20.8(y)0(,)-505.6(a)0(l)19.5(l)-513.8(do)20.8(wn)20(st)20.9(re)14(am)-499.9(an)19.7(al)13.8(ys)21(es)-504.3(fo)20.9(cu)19.7(se)14.1(d)-507.9(o)0(n)]TJ /F7 1 Tf 22.4225 0 TD (A.)Tj -23.4362 -1.1116 TD [(ra)15.3(di)20.7(or)21(es)19.9(is)15.1(te)19.6(ns)]TJ /F6 1 Tf 6.0074 0 TD [(50)20.8(v1)20.8(,)-464.2(w)0(h)20(i)0(c)13.8(h)-461.9(is)-457.1(th)20.7(e)-468.8(b)0(e)19.7(s)0(t)-457.1(c)0(h)19.7(a)0(r)19.7(a)0(c)18.5(t)0(e)19.6(r)0(i)15(z)0(e)18.5(d)-461.9(st)15.1(ra)19.7(in)]TJ -6.0074 -1.1116 TD [(am)18.5(on)15.1(g)-404.3(t)0(h)20.7(e)-411.2(sp)21(ac)18.5(ec)18.5(ra)14(ft)20.7(-a)19.7(ss)21.2(oc)19.7(ia)13.8(te)19.6(d)]TJ /F7 1 Tf 13.4547 0 TD [(Ac)18.5(in)15(et)19.5(ob)20.8(ac)19.7(te)19.6(r)]TJ /F6 1 Tf 5.5063 0 TD .4102 Tc [(;i)410.2(n)10.5(a)410.2(d)429.9(d)410.2(i)430.9(t)410.2(i)430.8(o)410.2(n)431(,)]TJ -18.961 -1.1174 TD 0 Tc [(at)-383.6(th)20.7(e)-393.9(s)0(p)21(e)0(c)18.5(i)0(e)13.8(s)-386.8(le)13.8(ve)19.7(l,)]TJ /F7 1 Tf 8.4898 0 TD [(A.)-380.1(ra)15.3(di)20.7(or)21(es)19.9(is)15.1(te)19.6(ns)]TJ /F6 1 Tf 7.1766 0 TD -.0196 Tc [(h)-19.6(a).1(s)-412.2(b)-19.6(ee)-19.6(n)-403.1(d)-19.6(et)-19.6(ec)-19.6(te)-19.6(d)-403.1(o)-19.6(n)]TJ -15.6664 -1.1116 TD 0 Tc [(Ma)18.8(rs)15.3(-b)20.9(ou)20.8(nd)-290.2(sp)21(ac)18.5(ec)12.8(ra)19.7(ft)-290.3(an)19.7(d)-300.6(i)0(n)-290.3(t)0(h)20.7(e)-301.8(IS)21(S)-300.4(\()0(s)21.1(u)0(r)20.9(f)0(a)19.7(c)0(e)12.8(s)-294.6(an)13.9(d)-294.8(d)0(r)15.1(i)0(n)20.7(k)0(i)20.7(n)0(g)]TJ T* [(wa)18.8(te)13.8(r\))-226.8(\(L)19.7(a)-238.4(D)0(u)20(c)]TJ /F7 1 Tf 6.2493 0 TD [(et)-222.4(al)15(.)]TJ /F6 1 Tf 1.9525 0 TD [(,)-239.6(2)0(0)20.8(0)0(3)20.8(;)-237.4(Ca)18.6(st)20.9(ro)]TJ /F7 1 Tf 5.7655 0 TD [(et)-228.1(al)20.7(.)]TJ /F6 1 Tf 1.9583 0 TD [(,)-239.6(2)0(0)20.8(0)0(4)20.8(;)-237.4(Mc)18.8(Co)19.8(y)]TJ /F7 1 Tf 6.1629 0 TD [(et)-228.1(al)20.7(.)]TJ /F6 1 Tf 1.9583 0 TD (,)Tj -24.0468 -1.1174 TD [(20)15.1(12)20.8(;)-352.6(M)0(o)19.9(i)0(s)20.9(s)0(l)15.1(-)0(E)19.7(i)0(c)19.6(h)0(i)20.7(n)0(g)20.8(e)0(r)]TJ /F7 1 Tf 9.7627 0 TD [(et)-343.3(al)20.7(.)]TJ /F6 1 Tf 2.0735 0 TD [(,)-354.8(2)0(0)20.8(1)0(3)20.8(;)-358.3(Sc)19.8(hu)20.8(er)19.7(ge)19.7(r)]TJ /F7 1 Tf 7.5395 0 TD [(et)-343.3(al)20.7(.)]TJ /F6 1 Tf 2.0735 0 TD -.0208 Tc [(,)-375.6(2)-20.8(01)-20.8(3;)]TJ -21.4491 -1.1116 TD 0 Tc [(De)18.8(re)14(ch)19.7(o)]TJ /F7 1 Tf 3.8187 0 TD [(et)-475.8(al)20.7(.)]TJ /F6 1 Tf 2.206 0 TD .4815 Tc [(,2)481.5(0)502.3(1)481.5(4)496.6(\))481.5(.)10.5(F)481.5(o)502.5(r)]TJ /F7 1 Tf 5.5984 0 TD 0 Tc [(A.)-472.3(ra)21(di)14.9(or)21(es)19.9(is)20.9(te)13.8(ns)]TJ /F6 1 Tf 7.3551 0 TD [(50)15.1(v1)20.8(,)-481.5(u)0(s)21(e)-486.1(of)]TJ -18.9782 -1.1116 TD [(et)13.8(ha)19.7(no)20.8(l)-266.2(a)0(s)-262.4(a)-267.2(so)15.3(le)-256.9(ca)18.5(rb)20.9(on)-261.4(so)21(ur)15.1(ce)-257.9(wa)18.8(s)-271.6(c)0(o)19.7(n)0()21(r)0(m)19.6(e)0(d)-262.5(t)0(h)20.7(r)0(o)20.9(u)0(g)20.8(h)-271.8(st)20.9(ab)19.7(le)]TJ 0 -1.1174 TD [(is)15.1(ot)20.7(op)20.8(e)-411.2(l)0(a)13.8(b)0(e)19.7(l)0(i)20.6(n)0(g)-399.6(\()0(u)15.1(s)0(i)20.9(n)0(g)]TJ 7.3823 0 0 6.5614 155.2251 499.4077 Tm -.0162 Tc (13)Tj 9.843 0 0 9.843 162.4252 494.9857 Tm 0 Tc [(C-)19.8(la)19.6(be)19.7(le)19.6(d)-415.8(e)0(t)19.5(h)0(a)19.7(n)0(o)20.8(l)0(\))-405.5(a)0(n)19.7(d)-410(un)20.8(ta)13.8(rg)20.9(et)19.5(ed)]TJ -10.4308 -1.1116 TD [(an)13.9(al)19.5(ys)21(es)19.9(,)-337.5(w)0(h)20(i)0(c)19.6(h)-340.9(su)21(pp)20.8(or)20.9(te)19.6(d)-340.9(f)0(u)20.9(l)0(l)-325(e)0(n)19.7(r)0(i)15(c)0(h)19.7(m)0(e)18.4(n)0(t)-324.9(o)0(f)]TJ 7.3823 0 0 6.5614 241.7385 488.4093 Tm -.0162 Tc (13)Tj 9.843 0 0 9.843 248.9385 484.0439 Tm 0 Tc [(C)-336.2(i)0(n)-324.9(t)0(h)20.7(e)-342.1(pr)20.9(i-)]TJ -19.2201 -1.1116 TD [(ma)18.4(ry)-336.2(me)18.4(ta)19.6(bo)20.8(lo)20.7(me)18.4(.)-349(C)0(o)19.8(n)0(s)21(i)0(s)20.9(t)0(e)19.6(n)0(t)-336.4(w)0(i)19.8(t)0(h)-336.4(t)0(h)20.7(e)-342.1(kn)15.1(ow)20(n)-340.9(m)0(i)19.5(c)0(r)19.7(o)0(b)15.1(i)0(o)20.7(l)0(o)20.7(g)0(y)]TJ 0 -1.1174 TD (of)Tj /F7 1 Tf 1.3651 0 TD [(A.)-535.6(ra)21(di)20.7(or)15.3(es)19.9(is)20.9(te)19.6(ns)]TJ /F6 1 Tf 7.4761 0 TD [(\(N)14.2(is)20.9(hi)20.7(mu)19.6(ra)]TJ /F7 1 Tf 5.0167 0 TD [(et)-533.4(al)20.7(.)]TJ /F6 1 Tf 2.2636 0 TD -.0166 Tc [(,)-555.7(1)-16.6(9)4.2(8)-16.6(8\))-16.6(,)-545.2(2)-16.6(-)4.3(p)-16.6(ro)-16.6(p)4.2(a)-16.6(no)-16.6(l)]TJ -16.1214 -1.1116 TD 0 Tc [(\(i)15(so)21(pr)20.9(op)20.8(yl)-221.2(al)19.5(co)19.7(ho)20.8(l,)-217.8(is)20.9(op)20.8(ro)15.1(pa)19.7(no)20.8(l\))-215.4(di)14.9(d)-225.7(n)0(o)20.8(t)-225.9(se)19.9(rv)15.1(e)-226.9(a)0(s)-216.3(a)-226.9(so)21(le)-222.4(ca)18.5(rb)20.9(on)]TJ T* [(so)15.3(ur)20.9(ce)18.5(;)-358.3(h)0(o)20.8(w)0(e)18.8(v)0(e)19.7(r)0(,)-344.3(c)0(u)19.7(l)0(t)14.8(i)0(v)20.7(a)0(t)19.5(i)0(o)20.7(n)0(s)-347.6(o)0(n)-342(m)0(i)19.5(x)0(t)15(u)0(r)20.9(e)0(s)-348.7(o)0(f)-342(e)0(t)19.5(h)0(a)13.9(n)0(o)20.8(l)-352.6(an)19.7(d)-358.2(2)0(-)]TJ T* [(pr)15.1(op)20.8(an)19.7(ol)-670.5(\(7)20.9(0/)20.7(30)-670.3(an)19.7(d)-680.7(5)0(0)20.8(/)0(5)20.7(0)-680.7(mi)19.5(xt)20.7(ur)20.9(es)14.1(\))-674.9(s)0(h)15.3(o)0(w)20(e)0(d)-671.5(e)0(n)19.7(h)0(a)19.7(n)0(c)19.7(e)0(d)]TJ 0 -1.1174 TD [(gr)15.1(ow)20(th)20.7(,)-418.1(a)0(s)-406.3(i)0(n)15(d)0(i)20.7(c)0(a)18.5(t)0(e)19.5(d)-415.8(by)-411.1(st)20.9(at)19.5(is)15.1(ti)20.6(ca)18.5(ll)20.6(y)-415.8(s)0(i)15.1(g)0(n)20.8(i)0()20.9(c)0(a)18.5(n)0(t)-411.3(i)0(n)20.7(c)0(r)19.7(e)0(a)18.5(s)0(e)19.9(s)-421.4(in)]TJ 0 -1.1116 TD [(pl)14.9(at)19.5(e)-324.8(c)0(o)19.7(u)0(n)20.8(t)0(s)-313.2(\()0(c)19.7(f)0(u)20.9(/)0(m)19.5(L)0(\))-314.4(a)0(t)-314.5(m)0(o)19.6(l)0(e)-314.5(r)0(a)14(t)0(i)20.6(o)0(s)-313(o)0(f)]TJ /F8 1 Tf 16.0062 0 TD ()Tj /F6 1 Tf .5414 0 TD [(0.)18.5(50)20.8(.)]TJ -15.5339 -1.1116 TD [(Bi)19.7(oc)19.7(he)13.9(m)15(i)0(c)13.8(a)0(l)-233.9(i)0(n)15(t)0(e)19.6(r)0(r)20.9(o)0(g)20.8(a)0(t)19.5(i)0(o)15(n)0(s)-238.2(s)0(u)21(p)0(p)20.8(o)0(r)20.9(t)0(e)19.6(d)-248.8(th)15(e)-244.2(o)0(x)20.8(i)0(d)15(a)0(t)19.5(i)0(o)20.7(n)-248.8(of)-238.3(bo)20.8(th)]TJ -1.0137 -1.1174 TD [(et)13.8(ha)19.7(no)20.8(l)-271.9(a)0(n)19.7(d)-277.6(2-)20.9(pr)20.9(op)20.8(an)19.7(ol)-267.3(by)-261.4(ex)19.7(tr)20.7(ac)12.8(ts)-261.3(of)]TJ /F7 1 Tf 15.1423 0 TD [(A.)-264.9(ra)15.3(di)20.7(or)21(es)19.9(is)15.1(te)19.6(ns)]TJ /F6 1 Tf 6.9404 0 TD [(50)20.8(v1)20.8(,)]TJ -22.0827 -1.1116 TD [(li)14.8(ke)19.7(ly)-336.4(du)20.8(e)-353.6(t)0(o)-336.4(a)-347.8(me)18.4(mb)19.6(ra)14(ne)19.7(-a)19.7(ss)21.2(oc)13.9(ia)19.6(te)19.6(d)-346.7(a)0(l)19.5(c)0(o)19.7(h)0(o)15.1(l)-346.8(de)19.7(hy)20.8(dr)15.1(og)20.8(en)19.7(as)19.9(e)]TJ T* [(\(S)15.3(in)20.7(ge)19.7(r)-300.6(a)0(n)19.7(d)-306.4(Fi)20.9(nn)20.8(er)19.7(ty)20.7(,)-302.9(1)0(9)20.8(8)0(5)15.1(\))0(.)-286.7(M)0(i)14(c)0(h)19.7(a)0(e)18.5(l)0(i)20.6(s)0()21(M)0(e)18.8(n)0(t)14.9(e)0(n)-291.3(k)0(i)20.7(n)0(e)19.7(t)0(i)20.6(c)0(s)-296.9(p)0(r)20.9(o)0(-)]TJ 0 -1.1174 TD [(vi)14.9(de)19.7(d)-254.5(a)-255.7(lo)20.7(w)]TJ /F7 1 Tf 4.89 0 TD (K)Tj /F6 1 Tf 7.3823 0 0 6.5614 114.3496 350.8723 Tm (M)Tj 9.843 0 0 9.843 123.4204 352.5164 Tm [(va)19.7(lu)20.7(e)-255.7(f)0(o)20.9(r)-260.3(et)19.5(ha)19.7(no)20.8(l)-260.4(\()]TJ /F9 1 Tf 7.2745 0 TD (*)Tj /F6 1 Tf .9907 0 TD [(0.)24.3(3)]TJ /F9 1 Tf 1.3823 0 TD (m)Tj /F6 1 Tf .5472 0 TD [(M\))20(,)-256.9(c)0(o)19.7(n)0(s)21(i)0(s)20.9(t)0(e)19.6(n)0(t)-250(w)0(i)19.8(t)0(h)]TJ -16.6628 -1.1116 TD [(th)15(e)-267.2(f)0(a)19.7(s)0(t)20.9(e)0(r)-262.5(g)0(e)19.7(n)0(e)19.7(r)0(a)19.7(t)0(i)20.6(o)0(n)-261.4(t)0(i)20.6(m)0(e)18.4(s)-265.8(ob)20.8(ta)19.6(in)15(ed)-256.8(at)-256.9(th)20.7(e)-267.2(l)0(o)15(w)0(e)18.8(r)-266(et)19.5(ha)19.7(no)15.1(l)-266.2(c)0(o)19.7(n)0(-)]TJ T* [(ce)18.5(nt)14.9(ra)19.7(ti)20.6(on)20.8(s)-335(i)0(n)-324.9(u)0(l)20.7(t)0(r)15(a)0(m)18.5(i)0(n)20.7(i)0(m)19.5(a)0(l)-326(m)0(e)18.4(d)0(i)20.7(u)0(m)19.6(.)-337.5(Ki)19.8(ne)19.7(ti)20.6(c)-336.3(s)0(t)20.9(u)0(d)20.8(i)0(e)13.8(s)-335(al)19.5(so)-324.5(in)20.7(-)]TJ T* [(di)14.9(ca)18.5(te)19.6(d)-415.8(a)-417(re)19.7(qu)20.8(is)15.1(it)20.6(e)-417(n)0(e)19.7(e)0(d)-406.5(f)0(o)20.9(r)-415.8(bo)20.8(th)-411.3(NA)19.1(D)]TJ /F8 1 Tf 7.3823 0 0 6.5614 217.8708 324.0566 Tm (+)Tj /F6 1 Tf 9.843 0 0 9.843 226.0346 319.6913 Tm -.0188 Tc [(a)-18.8(n).9(d)-434.6(a)-18.8(n)-425.3(e)-18.8(xo)-18.8(ge)-18.8(no)-18.8(us)]TJ -16.8932 -1.1174 TD 0 Tc [(el)13.8(ec)18.5(tr)20.7(on)-249.9(ac)18.5(ce)18.5(pt)20.7(or)-255.6(\(X)20(TT)-252.3(or)-249.8(DC)18.9(IP)21(\),)-252.2(th)20.7(er)19.7(eb)19.7(y)-260.3(s)0(u)15.3(p)0(p)20.8(o)0(r)20.9(t)0(i)20.6(n)0(g)-249.9(t)0(h)15(e)-261.4(fo)20.9(r-)]TJ 0 -1.1116 TD [(ma)18.4(ti)14.8(on)-399.6(of)-399.6(NA)19.1(DH)-401.4(\(a)14(lt)20.6(ho)20.8(ug)20.8(h)-410(t)0(r)20.7(a)0(n)13.9(s)0(i)20.9(e)0(n)19.7(t)0(l)20.6(y)-410(in)-405.5(ce)18.5(ll)20.6(ul)20.7(ar)-400.7(ex)19.7(tr)15(ac)18.5(ts)20.9(\))]TJ T* [(fr)15.1(om)-285.7(ei)19.5(th)15(er)-285.6(al)13.8(co)19.7(ho)20.8(l)-300.7(s)0(u)21(b)0(s)21(t)0(r)15(a)0(t)19.5(e)0(,)-287.9(w)0(h)20(i)0(c)19.6(h)]TJ /F7 1 Tf 14.6873 0 TD [(in)-290.3(vi)19.5(vo)]TJ /F6 1 Tf 3.0181 0 TD [(\(a)19.7(nd)-290.2(in)-290.3(th)20.7(e)-301.8(p)0(r)20.9(e)0(s)19.9(-)]TJ -17.7053 -1.1174 TD [(en)13.9(ce)-240.7(of)-244.1(in)20.7(ta)19.5(ct)-239.6(me)18.4(mb)19.6(ra)14(ne)19.7(s\))-238.1(wo)14.2(ul)20.7(d)-248.8(d)0(i)20.7(r)0(e)14(c)0(t)19.5(l)0(y)-238.5(s)0(u)21(p)0(p)15.1(o)0(r)20.9(t)-248.9(re)14(sp)21(ir)20.7(at)19.6(io)20.7(n.)]TJ 1.0137 -1.1116 TD [(Molecular)-388.9(and)-384.6(cultivation)-383.7(studies)-383.1(show)-385.2(that)-386(the)-379(oor)-384.4(of)]TJ -1.0137 -1.1116 TD [(the)-367.5(assembly)-369.2(facilities)-366.3(also)-368.4(harbor)-364.8(strains)-365.8(of)]TJ /F7 1 Tf 18.6557 0 TD (Acinetobacter)Tj /F6 1 Tf -18.6557 -1.1174 TD (\(Ghosh)Tj /F7 1 Tf 3.2024 0 TD [(et)-262.7(al.)]TJ /F6 1 Tf 2.0217 0 TD [(,)-262.6(2010;)-259.1(La)-263.7(Duc)]TJ /F7 1 Tf 6.3069 0 TD [(et)-262.7(al.)]TJ /F6 1 Tf 2.0217 0 TD [(,)-256.9(2012\),)-262.3(with)-264.7(human-based)]TJ -13.5526 -1.1116 TD [(activities)-475.7(possibly)-475.2(assisting)-471.7(in)-468.9(physical)-472(transport)-471.9(of)-474.5(these)]TJ T* [(microbes)-398.2(across)-394.4(the)-396.3(facilities.)-392.7(Molecular)-400.4(experiments)-397(with)]TJ /F7 1 Tf 0 -1.1174 TD [(A.)-449.2(radioresistens)]TJ /F6 1 Tf 7.43 0 TD [(50v1)-447.9(show)-448.6(that)-449.3(Kleenol)-448.9(30,)-449.1(an)-446.9(alkaline)]TJ -7.43 -1.1116 TD [(o)15.2(or)-255.6(de)19.7(te)19.5(rg)20.9(en)13.9(t,)-252.3(is)-261.3(bi)20.7(od)20.8(eg)19.7(ra)19.7(de)13.9(d)-266(u)0(n)20.8(d)0(e)19.7(r)-266(ul)20.7(tr)15(am)18.5(in)20.7(im)19.5(al)-256.9(co)19.7(nd)20.8(it)14.8(io)20.7(ns)]TJ T* [(in)15(to)-313.4(lo)20.7(we)18.8(r)-323.6(m)0(o)19.6(l)0(e)19.6(c)0(u)19.7(l)0(a)19.5(r)-323.6(we)18.8(ig)15(ht)-313.4(et)19.5(hy)20.8(le)19.6(ne)-314.4(gl)20.7(yc)19.7(ol)14.9(s.)]TJ 1.0137 -1.1116 TD [(Fu)21(rt)15(he)19.7(rm)19.6(or)20.9(e,)-380.1(un)20.8(ta)19.5(rg)20.9(et)13.8(ed)-377.7(an)19.7(al)19.5(ys)21(is)-382.3(of)-376.5(th)15(e)-388.2(e)0(x)19.7(t)0(r)20.7(a)0(c)18.5(e)0(l)19.6(l)0(u)15(l)0(a)19.6(r)-387(me)18.4(-)]TJ -1.0137 -1.1174 TD [(ta)13.8(bo)20.8(lo)20.7(me)-263.8(sh)21(ow)20(ed)-262.5(de)19.7(cr)19.7(ea)18.5(se)14.1(d)-266(a)0(b)19.7(u)0(n)15.1(d)0(a)19.7(n)0(c)19.7(e)0(s)-262.4(f)0(o)20.9(r)-271.8(se)19.9(ve)19.7(ra)14(l)-266.2(h)0(y)15.1(d)0(r)20.9(o)0(x)20.8(y)0(-)]TJ 0 -1.1116 TD [(an)13.9(d)-415.8(k)0(e)19.7(t)0(o)15(a)0(c)18.5(i)0(d)20.7(s)-421.4(in)-411.3(th)20.7(e)-422.7(p)0(r)20.9(e)0(s)19.9(e)0(n)19.7(c)0(e)-413.5(o)0(f)-411.1(K)0(l)19.8(e)0(e)18.5(n)0(o)15.1(l)-421.7(30)20.8(.)-418.1(I)0(n)20.9(t)0(e)19.5(r)0(e)14(s)0(t)20.9(i)0(n)20.7(g)0(l)20.7(y)0(,)]TJ T* [(th)15(es)19.9(e)-440(h)0(y)20.8(d)0(r)20.9(o)0(x)20.8(y)0(-)-434.1(a)0(n)19.7(d)-438.8(ke)19.7(to)20.7(ac)18.5(id)20.7(s)-438.6(s)0(h)15.3(a)0(r)19.7(e)-440(ir)20.7(on)20.8(-b)15.1(in)20.7(di)20.7(ng)-428.4(pr)20.9(op)15.1(er)19.7(ti)20.6(es)]TJ 0 -1.1174 TD [(\(D)14.2(re)19.7(ch)19.7(se)19.9(l)]TJ /F7 1 Tf 4.0664 0 TD [(et)-245.4(al)20.7(.)]TJ /F6 1 Tf 1.9756 0 TD [(,)-245.3(1)0(9)15.1(9)0(3)20.8(;)-248.9(Sc)19.8(ho)20.8(e)14.1(ld)-238.5(an)19.7(d)-248.8(Z)0(h)19.6(a)0(n)19.7(g)0(,)-240.7(1)0(9)15.1(9)0(9)20.8(;)-248.9(Yu)20(e)]TJ /F7 1 Tf 16.0293 0 TD [(et)-245.4(al)20.7(.)]TJ /F6 1 Tf 1.9698 0 TD (,)Tj -24.041 -1.1116 TD [(20)15.1(03)20.8(\))-340.9(a)0(n)19.7(d)0(,)-327.1(h)0(e)13.9(n)0(c)19.7(e)0(,)-328.2(r)0(e)19.7(v)0(e)13.9(a)0(l)-326(a)-342.1(po)20.8(te)13.8(nt)20.7(ia)19.6(l)-341(i)0(m)19.5(p)0(a)19.7(c)0(t)-331.8(t)0(o)-330.6(t)0(h)20.7(e)-342.1(tr)20.7(an)19.7(sp)15.3(or)20.9(t/)]TJ T* [(me)18.4(ta)13.8(bo)20.8(li)20.6(sm)-487(of)-491.7(ex)19.7(tr)20.7(ac)18.5(el)19.5(lu)15(la)19.6(r)-433(i)0(r)15(o)0(n)20.8(.)-435.4(Ou)20(r)-438.8(s)0(t)20.9(u)0(d)20.8(i)0(e)19.6(s)-438.6(al)19.5(so)-428.2(in)20.7(di)20.7(ca)18.5(te)]TJ 0 -1.1174 TD [(th)15(at)-406.7(de)19.7(ca)18.5(no)20.8(at)19.5(e)-417(\()0(f)15.1(o)0(r)20.9(m)0(e)18.4(d)-415.8(du)20.8(ri)15(ng)-405.4(in)20.7(cu)19.7(ba)19.7(ti)14.8(on)-405.4(in)-405.5(Kl)19.8(ee)18.5(no)20.8(l)-421.7(3)0(0)-405.4(i)0(n)]TJ 0 -1.1116 TD [(0.)18.5(2)]TJ /F8 1 Tf 1.3881 0 TD ()Tj /F6 1 Tf .7084 0 TD [(M9)19.9(/F)15.1(e/)19.5(et)19.5(ha)19.7(no)20.8(l\))-192.4(is)-198(bi)20.7(od)20.8(eg)19.7(ra)19.7(de)19.7(d)-202.7(b)0(y)]TJ /F7 1 Tf 13.4316 0 TD [(A.)-190(ra)21(di)15(or)21(es)19.9(is)20.9(te)13.8(ns)]TJ /F6 1 Tf 6.7965 0 TD [(50)20.8(v1)]TJ -22.3246 -1.1116 TD [(\(F)15.3(ig)20.7(.)-423.9(5)0(\))15.1(,)-423.9(wi)19.8(th)-417(th)15(e)-428.5(r)0(e)19.7(s)0(u)21(l)0(t)20.6(s)-427.1(\(F)15.3(ig)20.7(.)-423.9(5)0(B)19.8(\))-427.3(su)15.3(gg)20.8(es)19.9(ti)20.6(ng)-416.9(co)13.9(nc)19.7(om)19.6(it)20.6(an)19.7(t)]TJ 0 -1.1174 TD [(in)15(cr)19.7(ea)18.5(se)19.9(s)-421.4(i)0(n)-417(a)0(b)19.7(u)0(n)20.8(d)0(a)19.7(n)0(c)19.7(e)0(s)-417.9(o)0(f)-411.1(s)0(u)21(b)0(e)19.7(r)0(i)20.7(c)-428.5(ac)18.5(id)-411.3(\(o)20.9(ct)19.5(an)19.7(ed)13.9(io)20.7(ic)-412.4(ac)18.5(id)20.7(\),)]TJ 0 -1.1116 TD [(wh)14.2(ic)19.6(h)-179.6(a)0(l)13.8(o)0(n)20.8(g)-179.6(wi)14.1(th)-169.4(ac)18.5(et)13.8(yl)20.7(-C)19.8(oA)-175.9(wo)20(ul)20.7(d)-185.4(p)0(o)20.8(t)0(e)19.6(n)0(t)20.7(i)0(a)19.6(l)0(l)14.8(y)-179.6(be)-176.2(a)-186.6(m)0(e)18.4(t)0(a)19.5(b)0(o)20.8(l)0(i)20.6(c)]TJ 25.5097 67.9184 TD [(pr)20.9(od)20.8(uc)19.7(t)-243.1(o)0(f)]TJ /F9 1 Tf 4.3083 0 TD (o)Tj /F6 1 Tf .6566 0 TD [(-o)15.1(xi)20.7(da)19.7(ti)20.6(on)-232.6(of)-232.6(de)19.7(ca)18.5(no)15.1(at)19.6(e)-244.2(\()0(D)20(o)0(n)20.8(o)0(g)20.8(h)0(u)20.8(e)-244.2(an)19.7(d)-243(T)0(r)19.7(u)0(d)20.8(g)0(i)14.9(l)0(l)20.6(,)]TJ -4.9649 -1.1174 TD [(19)20.8(75)20.8(;)-260.4(K)0(u)20(n)0(z)-251(a)0(n)19.7(d)-260.3(We)17.4(im)19.5(er)14(,)-256.9(1)0(9)20.8(8)0(3)20.8(;)-260.4(Va)13(n)-254.5(B)0(o)14(g)0(a)19.7(e)0(r)19.7(t)]TJ /F7 1 Tf 18.0624 0 TD [(et)-251.2(al)20.7(.)]TJ /F6 1 Tf 1.9813 0 TD .2569 Tc [(,2)256.9(0)272(1)256.9(1)277.7(\))256.9(.)]TJ -19.0301 -1.1116 TD 0 Tc [(Under)-554.7(ultraminimal)-560(conditions,)-563(we)-557.2(also)-552.7(show)-558(that)]TJ /F7 1 Tf 22.411 0 TD (A.)Tj -23.4247 -1.1116 TD (radioresistens)Tj /F6 1 Tf 6.2435 0 TD [(50v1)-574.6(exhibits)-580.4(a)-572.5(remarkable)-581.4(oxidative)-582.8(ex-)]TJ -6.2435 -1.1116 TD [(tremotolerance)-322.3(when)-317.5(cultivated)-326(on)-313.2(ethan)-8(ol)-313.4(as)-320(a)-319(sole)-316.5(carbon)]TJ 0 -1.1174 TD [(source)-377.3(\()]TJ /F9 1 Tf 3.3233 0 TD (*)Tj /F6 1 Tf .9964 0 TD [(1.5-log)-378.8(reduction,)]TJ /F9 1 Tf 7.6546 0 TD (*)Tj /F6 1 Tf 1.0022 0 TD (10)Tj 7.3823 0 0 6.5614 448.4408 674.7021 Tm (8)Tj 9.843 0 0 9.843 455.8109 670.3369 Tm [(cfu/mL,)-376.6(10)-169.2(mM)-372.9(H)]TJ 7.3823 0 0 6.5614 529.7384 668.6927 Tm (2)Tj 9.843 0 0 9.843 533.4235 670.3369 Tm (O)Tj 7.3823 0 0 6.5614 540.5101 668.6927 Tm (2)Tj 9.843 0 0 9.843 544.1951 670.3369 Tm (\).)Tj -23.7069 -1.1116 TD [(This)-420.2(assessment)-429.8(is)-422.6(based)-422.3(on)-422.7(comparisons)-424.3(with)-426(other)-421.5(non-)]TJ T* [(spore)-593.9(forming)-596.5(radiation)-594.3(and)-592(oxidation-resistan)-12(t)-588.7(bacteria.)]TJ 0 -1.1174 TD [(For)-366(instance,)-367.1(the)-361.7(survivabilit)-9(y)-364(o)0(f)]TJ /F7 1 Tf 13.8867 0 TD [(A.)-362.8(radioresistens)]TJ /F6 1 Tf 7.2572 0 TD [(50v1)-367.3(in)]TJ -21.1439 -1.1116 TD [(nutrient-poor)-493.8(medium)-494.2(is)-491.7(comparable)-500.8(with)-489.3(that)-495.4(of)]TJ /F7 1 Tf 21.5067 0 TD (Deino-)Tj -21.5067 -1.1116 TD [(coccus)-297.9(radiodurans)]TJ /F6 1 Tf 8.2594 0 TD [(R1)-297(\()]TJ /F9 1 Tf 1.797 0 TD (*)Tj /F6 1 Tf 1.0022 0 TD [(1-log)-299.3(reduction)-300.4(in)-296.1(33)-163.5(mM)-298.1(H)]TJ 7.3823 0 0 6.5614 532.1762 613.9274 Tm (2)Tj 9.843 0 0 9.843 535.8613 615.5715 Tm (O)Tj 7.3823 0 0 6.5614 542.9479 613.9274 Tm (2)Tj 9.843 0 0 9.843 546.6329 615.5715 Tm (\))Tj -23.9546 -1.1174 TD [(and)-344.3(that)-351.4(of)]TJ /F7 1 Tf 4.8324 0 TD [(Vibrio)-347.7(rumoiensis)]TJ /F6 1 Tf 7.6431 0 TD [(S-1T)-351(\()]TJ /F9 1 Tf 2.684 0 TD (*)Tj /F6 1 Tf .9964 0 TD [(1.5-log)-350(reduction)-352.3(in)]TJ -16.156 -1.1116 TD [(0.4)-166.9(mM)-574.5(H)]TJ 7.3823 0 0 6.5614 353.9338 591.9872 Tm (2)Tj 9.843 0 0 9.843 357.6188 593.6313 Tm (O)Tj 7.3823 0 0 6.5614 364.7054 591.9872 Tm (2)Tj 9.843 0 0 9.843 368.3904 593.6313 Tm [(\))-577(when)-576.7(cultivated)-579.5(in)-578.3(nutrient-rich)-581.5(medium)]TJ -5.8461 -1.1116 TD (\()Tj /F7 1 Tf .3283 0 TD [(e.)11.6(g.)]TJ /F6 1 Tf 1.4284 0 TD [(,)-268.4(L)0(B)12.9(,)-268.4(try)13.9(pti)13.7(c)-273(soy)-256.5(bro)14(th,)-259.2(and)-257.9(pep)12.8(ton)13.9(e)-267.2(yea)11.7(st)-267.1(ex)13.9(tra)12.7(ct)-268.4(sta)12.9(rc)14(h\))]TJ -1.7567 -1.1116 TD [(\(Ar)13.2(rag)12.9(e)]TJ /F7 1 Tf 3.4616 0 TD [(et)-372.1(al.)]TJ /F6 1 Tf 2.1138 0 TD [(,)-377.8(199)14(3;)-371(Ich)12.8(ise)]TJ /F7 1 Tf 6.0131 0 TD [(et)-372.1(al.)]TJ /F6 1 Tf 2.1196 0 TD [(,)-377.8(1)0(9)15.1(99\))14(.)-377.8(Hen)11.9(ce,)-370.8(by)-370.8(ext)12.7(en)13.9(-)]TJ -13.7081 -1.1174 TD [(sio)14(n,)-488.3(the)12.7(se)-492.7(res)13(ult)13.7(s)-496.2(sup)14.2(por)14(t)-496.6(the)-488.4(po)15.1(ten)12.7(tia)12.6(l)-496.6(for)-487.1(oxi)13.8(dat)12.7(ive)-488.4(ex)13.9(-)]TJ 0 -1.1116 TD [(tre)12.7(mo)13.9(tol)13.7(era)11.7(nce)-742.9(und)14(er)-740.6(oli)13.7(got)13.8(rop)14(hic)-741.8(con)12.8(di)14.9(tio)13.7(ns,)-742.7(whi)13(ch)-740.6(is)]TJ T* [(sig)14(ni)14(ca)12.8(nt,)-184.3(as)-181.7(des)13(icc)11.5(ati)12.6(ng)-180.8(env)12.8(iro)13.9(nme)11.6(nt)14.9(s)-191(\(su)14.2(ch)-187.7(as)-181.7(the)-183.1(ass)13.2(emb)11.6(ly)]TJ 0 -1.1174 TD [(fac)11.7(il)14.8(iti)13.6(es\))-246.1(are)-241.7(tho)13.8(ug)15.1(ht)-250(to)-244.2(pro)14(mo)13.9(te)-251.2(ox)15.1(ida)12.7(tiv)13.7(e)-249.9(str)14.1(ess)-246(thr)13.9(ou)15.1(gh)-249.9(the)]TJ 0 -1.1116 TD [(for)14(ma)12.7(tio)13.7(n)-323.6(o)0(f)-319(rea)11.7(cti)18.3(ve)-320.1(oxy)14(gen)-315.5(spe)13(ci)13.8(es)-320(\(Bi)12.8(lli)-314.7(and)-309.7(Pot)14(ts,)-316.6(200)19.7(2;)]TJ T* [(Fra)13(nca)]TJ /F7 1 Tf 2.9778 0 TD [(et)-268.4(al.)]TJ /F6 1 Tf 2.0159 0 TD [(,)-274.1(200)14(7\).)]TJ -3.98 -1.1174 TD [(In)-284.4(th)14.9(e)-290.2(con)12.8(tex)12.7(t)-289.2(o)0(f)-284.4(sur)14.2(viv)13.8(al)-285.7(in)-284.6(the)-281.1(ass)13.2(emb)11.6(ly)-284.5(fa)13.9(cil)12.6(iti)13.6(es,)-283.1(the)12.7(re)14(-)]TJ -1.0137 -1.1116 TD [(for)14(e,)-230.3(the)12.7(se)-233.6(com)11.6(bi)15(ned)-229.1(res)13(ult)13.7(s)-237(sup)14.2(por)14(t)-237.4(the)-229.2(pot)13.8(ent)18.4(ial)-229.4(for)-227.9(eth)12.7(ano)12.8(l,)]TJ T* [(2-p)14(rop)14(an)13.9(ol,)-259.2(an)13.9(d)-266(per)12.8(hap)12.8(s)-265.9(K)0(l)14.1(een)11.7(ol)-261.5(30)-261.4(to)-255.7(\(1\))-256.7(ser)13(ve)-256.8(as)-262.4(car)11.7(bon)-251(or)]TJ 0 -1.1174 TD [(ene)11.7(rg)15.1(y)-294.8(sou)19.9(rce)11.7(s)-288.9(und)14(er)-285.6(oli)13.7(got)13.8(rop)14(hic)-281.1(con)12.8(dit)13.7(io)15(ns)-290(an)13.9(d)-294.8(\()0(2)15.1(\))-294.8(sus)14.4(ta)13.8(in)]TJ 0 -1.1116 TD [(ext)12.7(re)14(mot)12.6(ole)12.7(ran)12.8(ces)-425.9(aga)11.7(ins)14(t)-433.2(the)-430.8(ox)15.1(ida)12.7(tiv)13.7(e)-434.2(str)14.1(ess)13.2(es)-435.1(ass)13.2(oci)12.7(ate)17.3(d)]TJ T* [(wit)12.8(h)-317.9(low)13(-hu)14(mi)13.7(dit)13.7(y)-323.6(e)0(n)13.9(vir)13.9(onm)12.7(ent)12.7(s.)-315.4(For)-308.4(rec)11.7(ent)-309.9(Mar)11.9(s)-317.7(mis)12.8(sio)14(ns,)]TJ T* [(how)13.1(ev)13.9(er,)-173.8(the)-177.4(sur)14.2(fac)11.7(e)-180.8(cle)11.5(ani)12.7(ng)-175(pro)14(ced)11.7(ure)18.6(s)-185.2(wer)12(e)-180.8(pre)12.9(dom)12.8(ina)12.7(ntl)19.5(y)]TJ 0 -1.1174 TD 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310.8472 116.9008 Tm [(5.)-501.1(Conclusion)]TJ /F6 1 Tf 9.843 0 0 9.843 320.8251 100.4598 Tm [(In)-416.9(sum,)-422.5(this)-419.2(study)-420.1(provides)-424.6(a)-422.7(plausible)-421.4(biochemical)-427.3(ra-)]TJ -1.0137 -1.1116 TD [(tionale)-603.7(to)-601.3(the)-603.6(observed)-604.2(microbial)-607.1(ecology)-609.2(dynamics)-605.6(of)]TJ T* [(spacecraft)-408.4(assembly)-403.8(facilities,)-404.3(as)-406.3(spacecraft-associated)-413.5(mi-)]TJ 0 -1.1174 TD [(croorganisms)-379.3(\(such)-380.8(as)-377.6(the)]TJ /F7 1 Tf 11.1393 0 TD (Acinetobacter)Tj /F6 1 Tf 5.633 0 TD [(\))-381.2(may)-374.3(metabolize/)]TJ -16.7723 -1.1116 TD [(biodegrade)-256.5(spacecraft)-264.4(cleaning)-254.5(reagents)-259.9(and)-257.9(exhibit)-256.9(extreme)]TJ /F5 1 Tf 8.9663 0 0 8.9663 59.7543 749.7069 Tm [(SURVIVAL)-340.1(ON)-334.6(SPACECRAFT)-335.2(CLEANING)-337.5(REAGENTS)-28647.3(9)]TJ ET endstream endobj 99 0 obj <>stream /GS1 gs BT /F6 1 Tf 9.843 0 0 9.843 62.022 725.1588 Tm 0 0 0 rg .0125 Tc 0 Tw 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2.1426 0 TD .0069 Tc [(,)-336.4(2)-5.7(01)-5.7(3\))-5.7(.)]TJ -10.5691 -1.1174 TD 0 Tc [(In)-399.6(the)-407.8(framework)-405.9(of)-405.3(planetary)-405.3(protection,)-403(therefore,)-408.5(the)]TJ -1.0137 -1.1116 TD [(Gram-negative)-516.6(and)-517.1(nonspore)-510.8(forming)]TJ /F7 1 Tf 16.4152 0 TD (Acinetobacter)Tj /F6 1 Tf 6.1456 0 TD (may)Tj -22.5608 -1.1116 TD [(tolerate)-456.2(partial)-459.6(sterilizations)-457(with)-454.8(vaporous)-453.3(hydrogen)-453.4(per-)]TJ T* [(oxide,)-401.9(and)-396.1(survive)-400.4(the)-402(heat)-398.5(treatments)-401.8(associated)-407.2(with)-397.2(the)]TJ 0 -1.1174 TD [(NASA)-352.4(Standard)-356.7(Assay,)-350.4(which)-353.3(could)-352.4(possibly)-354.3(impact)-356(treat-)]TJ 0 -1.1116 TD [(ments)-445.6(and)-436.4(measurements)-446.3(for)-441(missions)-447.5(requiring)-437.5(very)-443.3(low)]TJ T* [(bioburden)-420.1(values)-417.8(\()]TJ /F7 1 Tf 7.7929 0 TD (e.g.)Tj /F6 1 Tf 1.4457 0 TD [(,)-418.1(life)-420.5(detection)-417(and)-419.2(Special)-420.2(Regions)]TJ -9.2386 -1.1174 TD [(missions\).)-354(Furthermore,)-347.3(our)-348.9(work)-350.8(lends)-352.2(support)-347.4(toward)-348.6(the)]TJ 0 -1.1116 TD [(use)-344.1(of)-336.2(differing)-345.3(\(and)-339.6(rotating\))-345.5(spacecraft-compatible)-350.7(clean-)]TJ T* [(ing)-395.1(reagents)-398.1(as)-394.8(a)-399.7(means)-394.8(of)-393.8(controlling)-399.7(the)-396.2(core)-392.6(spacecraft)]TJ 0 -1.1174 TD (microbiome.)Tj /F5 1 Tf 8.9663 0 0 8.9663 62.022 474.5763 Tm (Acknowledgments)Tj /F6 1 Tf 9.843 0 0 9.843 72 458.1353 Tm [(Special)-241.7(thanks)-238.1(go)-238.3(to)-238.5(Robert)-239.3(Wedge,)-243.9(Tynan)-238.3(Young,)-240.2(Nestor)]TJ -1.0137 -1.1116 TD [(Aq)20(ui)20.7(no)15.1(,)-274.1(O)0(m)18.7(a)0(r)-268.3(M)0(e)18.8(r)0(c)19.7(a)0(d)19.7(o)0(,)-269.5(A)0(l)19.8(e)0(x)19.7(a)-278.7(Wo)18.6(ll)20.6(en)13.9(,)-274.1(a)0(n)19.7(d)-277.6(Ty)19.6(fa)19.7(nn)20.8(i)-277.7(N)0(g)14.2(u)0(y)20.8(e)0(n)]TJ T* [(fo)20.9(r)-312.1(t)0(h)20.7(e)0(i)13.8(r)-306.3(co)13.9(nt)20.7(ri)20.7(bu)20.8(ti)20.6(on)15.1(s.)-298.1(Th)19.6(is)-301.6(st)15.1(ud)20.8(y)-312.1(w)0(a)18.8(s)-311.9(fu)20.9(nd)20.8(ed)-302.9(an)19.7(d)-312.1(s)0(u)21(p)0(p)20.8(o)0(r)15.1(t)0(e)19.6(d)]TJ 0 -1.1174 TD [(by)-365.1(th)15(e)-376.6(F)0(a)19.8(c)0(u)19.7(l)0(t)20.6(y)-375.5(mi)19.5(ni)15(-g)20.9(ra)19.7(nt)-365.2(pr)15.1(og)20.8(ra)19.7(m)-376.7(\()0(R)19.8(.)0(M)17.6(.)0(\))18.5(,)-372(Pr)15.3(ov)20.8(os)21(t-)20.7(Te)12.7(ac)18.5(he)19.7(r)]TJ 0 -1.1116 TD [(Sc)19.8(ho)20.8(la)13.8(r)-335.1(p)0(r)20.9(o)0(g)15.1(r)0(a)19.7(m)-336.4(\(R)19.8(.M)17.6(.\))18.5(,)-337.5(C)0(o)19.8(l)0(l)20.6(e)0(g)13.9(e)-336.3(of)-330.5(Sc)19.8(ie)19.6(nc)19.7(e)-342.1(\()0(G)20(.)0(B)17.5(.)0(\))18.5(,)-337.5(an)19.7(d)-340.9(t)0(h)20.7(e)]TJ T* [(Ch)19.8(em)18.5(is)20.9(tr)15(y)-306.4(a)0(n)19.7(d)-306.4(Bi)19.7(oc)19.7(he)19.7(mi)19.5(st)15.1(ry)-295.9(De)18.8(pa)19.7(rt)20.7(me)18.4(nt)-301.8(\(R)19.8(.)13.9(M)0(.)-299.2(a)0(n)19.7(d)-306.4(G.)17.6(B.)17.5(\))-306.3(a)0(t)]TJ 0 -1.1174 TD [(Ca)18.6(l)-323.8(P)0(o)21(l)0(y)-313.4(P)0(o)15.2(m)15(on)15.1(a.)]TJ /F5 1 Tf 8.9663 0 0 8.9663 62.022 371.9621 Tm [(Author)-338.7(Contributions)]TJ /F6 1 Tf 9.843 0 0 9.843 72 355.5212 Tm [(All)-309.7(listed)-307.5(authors)-308.3(contributed)-314.3(to)-307.6(the)-309.9(acquisition,)-306.2(analy)-8(sis,)]TJ -1.0137 -1.1116 TD [(or)-434.1(interpretation)-440(of)-428.4(the)-436.6(data,)-436.5(and)-430.7(drafting)-436.4(of)-434.1(critical)-433.2(revi-)]TJ T* [(sions/reports)-562.4(of)-555.1(the)-551.8(work.)-555.9(The)-558.6(primary)-557.3(investigator)-557.3(and)]TJ 0 -1.1174 TD [(corresponding)-655.9(author)-647.2(is)-653(R.M.)-650.3(Enzymology)-654.1(experiments)]TJ 0 -1.1116 TD [(were)-295.6(conducted)-301.5(by)-290.2(R.B.,)-296.8(H.B.,)-296.6(V.N.,)-296.5(and)-292.4(G.S.)-297.8(Survivability)]TJ T* [(experiments)-310.6(in)-301.8(hydrogen)-303.7(peroxide)-305(were)-307.1(conducted)-307.3(by)-301.7(S.Le.)]TJ 0 -1.1174 TD [(Microbiological)-292.3(assays)-290.6(were)-289.8(conducted)-290(by)-290.2(M.A.,)-285(I.C.,)-290(T.G.,)]TJ 0 -1.1116 TD [(S.G.,)-243.6(M.H.,)-238.9(C.J.,)-243.7(E.K.,)-239.2(T.N.,)-245(A.O.,)-238.9(J.R.,)-243.7(M.S.,)-243.6(N.T.,)-239.2(and)-240.6(J.W.)]TJ T* [(Cultivation)-268.4(experiments)-264.5(with)-264.7(Kleenol)-264.6(30)-261.4(were)-261(conducted)-267(by)]TJ 0 -1.1174 TD [(SLa)-333.8(and)-338.5(SM,)-334.7(whereas)-340.1(those)-334.9(with)-333.8(stable)-337.3(isotopes)-338.2(were)-335.9(con-)]TJ 0 -1.1116 TD [(ducted)-487.1(by)-480.3(N.P.)-482.1(G.B.)-489(supervised)-485.3(and)-482.5(directed)-484.8(the)-488.4(isotope)]TJ T* [(labeling)-334.1(and)-338.5(metabolite)-338.8(proling)-331.4(by)-336.3(S.La,)-334.9(S.M.,)-330(and)-332.8(N.P.)]TJ /F5 1 Tf 8.9663 0 0 8.9663 62.022 214.7527 Tm [(Author)-338.7(Disclosure)-330.4(Statement)]TJ /F6 1 Tf 9.843 0 0 9.843 72 198.3117 Tm [(No)-331.4(competing)-336.3(nancial)-340.7(interests)-334.7(exist.)]TJ /F5 1 Tf 8.9663 0 0 8.9663 62.022 176.3716 Tm (References)Tj /F6 1 Tf 9.2951 0 0 9.2951 62.022 160.3275 Tm .012 Tc [(Ab)5.8(bo)5.8(tt,)-451.6(B.)5.8(J.,)-445.5(L)-2.2(ask)5.8(i).2(n,)-445.5(A.)5.8(,)-451.6(a)1.6(nd)-451.7(M)12(c)-4(Coy,)-445.5(C.)-451.6(\(19)5.8(73\))-447.9(Gro)5.8(w)-1.9(th)-445.6(of)]TJ /F7 1 Tf .9149 -1.1223 TD .0103 Tc [(Ac)-6.2(i)10.3(n)-7.7(etobact)10.3(e)-5.8(r)-300(c)-6.2(alcoaceticus)]TJ /F6 1 Tf 11.9667 0 TD .0083 Tc [(on)-302.9(et)-3.5(han)-4(o)-4(l)8.3(.)]TJ /F7 1 Tf 4.9038 0 TD .0123 Tc [(Ap)6.1(pl)-298.3(M)3.6(i).5(cro)6.1(b)0(io)6.1(l)]TJ /F6 1 Tf 6.636 0 TD (25:)Tj -23.5064 -1.1284 TD [(78)6.1(77)6.1(92)6.1(.)]TJ -.9149 -1.1223 TD 0 Tc [(Ar)20.2(ra)17.6(ge)19.9(,)-262.3(A)0(.)22.6(,)-262.3(Ph)21.2(el)14.4(ps)25(,)-262.3(T)0(.)16.2(,)-256.2(Be)15.1(no)24.1(it)19.2(,)-262.3(R)0(.)19.4(,)-262.3(a)14(n)0(d)-250.4(W)0(h)19.8(i)0(t)19.2(e)0(,)-254.5(D)0(.)-251.9(\()0(1)21.8(9)0(9)18(3)0(\))-246.6(S)0(u)15.1(r)0(v)21.8(i)12.6(va)13.8(l)]TJ .9149 -1.1284 TD [(of)-435.7(su)18.9(bs)18.9(ur)21.8(fa)17.6(ce)-441.7(m)12.5(i)0(c)20.5(r)0(o)15.7(o)0(r)21.8(g)0(a)19.9(n)0(i)18.6(s)0(m)19.3(s)-444.5(ex)13.8(po)24.1(se)14.7(d)-445.4(t)12.6(o)-445.4(U)0(V)-442.6(r)0(a)23.7(d)0(i)18.6(a)0(t)14.4(i)12.6(on)-433.3(an)13.8(d)]TJ 0 -1.1223 TD [(hy)18(dr)21.8(og)18(en)-315.6(pe)19.9(ro)21.8(xi)18.6(de)19.9(.)]TJ /F7 1 Tf 8.0388 0 TD [(Ap)16.1(pl)-310.8(En)22.2(vi)14.4(r)12.9(o)0(n)-317.4(M)0(i)22.2(c)0(r)20.8(o)0(b)18(i)0(o)18.6(l)]TJ /F6 1 Tf 9.9357 0 TD -.018 Tc [(5)-18(9)0(:)-5.4(3)-18(54)-18(5)-18(3)6.1(5)-18(50)-18(.)]TJ -18.8893 -1.1284 TD 0 Tc [(Barding,)-420.5(G.A.,)-412.3(Jr.,)-416.6(Be)]TJ 8.8622 .0427 TD ()Tj .3843 -.0427 TD [(ni,)-414.5(S.,)-411.8(Fukao,)-416.6(T.,)-416.9(Bailey-Serres,)-421.7(J.,)-414.2(and)]TJ -8.3316 -1.1223 TD [(Larive.)-452.1(C.K.)-458.1(\(2013\))-450.8(Comparison)-450(of)-453.9(GC-MS)-456.8(and)-449.9(NMR)-451.3(for)]TJ 0 -1.1284 TD [(metabolite)-255.3(proling)-249.2(of)-246.6(rice)-248.6(subjected)-255.9(to)-243.7(submergence)-257.3(stress.)]TJ /F7 1 Tf 24.3603 0 TD (J)Tj -24.3603 -1.1284 TD [(Proteome)-334.8(Res)]TJ /F6 1 Tf 6.0077 0 TD (12:898909.)Tj 20.0848 70.8975 TD [(Barengoltz,)-270.2(J.B.)-266.6(\(1997\))-267.8(Microbiological)-269.7(cleanliness)-271.1(of)-264.9(the)-272.4(Mars)]TJ .9149 -1.1223 TD [(Pathnder)-377.1(spacecraft,)-373.4(Los)-367.4(Angeles,)-375.6(California,)-371.4(USA.)-372.5(Avail-)]TJ 0 -1.1284 TD [(able)-337.8(online)-333.3(at)-333.3(http://hdl.handle.net/2014/21747)]TJ -.9149 -1.1223 TD [(Begot,)-344.7(C.,)-340.5(Desnier,)-341.3(I.,)-338.1(Daudin,)-341.6(J.D.,)-336.7(Labadie,)-344.4(J.C.,)-339.9(and)-340.1(Lebert,)]TJ .9149 -1.1283 TD [(A.)-410.4(\(1996\))-408.1(Recommendations)-411.3(for)-413.7(calculating)-406.5(growth)-412.8(param-)]TJ 0 -1.1223 TD [(eters)-345.4(by)-341.8(optical)-343.2(density)-338.6(measurements.)]TJ /F7 1 Tf 16.224 0 TD [(J)-339.8(Microbiol)-346.9(Methods)]TJ /F6 1 Tf -16.224 -1.1284 TD (25:225232.)Tj -.9149 -1.1223 TD [(Benardini,)-290.2(J.N.,)-287.9(III.,)-282(La)-286.9(Duc,)-286.9(M.T.,)-282.2(Beaudet,)-292.4(R.A.,)-281.3(and)-285.2(Koukol,)]TJ .9149 -1.1284 TD [(R.)-261.2(\(2014\))-261.7(Implementing)-266.1(planetary)-265.2(protection)-260.5(measures)-264(on)-256.4(the)]TJ 0 -1.1223 TD [(Mars)-340.9(Science)-337.3(Laboratory.)]TJ /F7 1 Tf 10.8871 0 TD (Astrobiology)Tj /F6 1 Tf 5.5137 0 TD (14:2732.)Tj -17.3157 -1.1284 TD (Bergogne-Be)Tj 4.9587 .0427 TD ()Tj .3904 -.0427 TD (re)Tj .3965 .0427 TD ()Tj .3843 -.0427 TD [(zin,)-284.7(E.,)-288.8(Friedman,)-288.3(H.,)-288.5(and)-285.2(Bendinelli,)-293(M.)-286.1(\(2008\))]TJ /F7 1 Tf -5.2148 -1.1223 TD (Acinetobacter)Tj /F6 1 Tf 5.6357 0 TD [(:)-499.7(Biology)-492.6(and)-492.6(Pathogenesis.)-502.4(Springer-Verlag,)]TJ -5.6357 -1.1284 TD [(New)-337.2(York.)]TJ -.9149 -1.1284 TD .0129 Tc [(Billi)12.9(,)-425.9(D)5.1(.,)-414.1(an)6.7(d)-420.3(P)3.8(o)6.7(tts,)-414.1(M)1.3(.)-414.1(\()-1.8(2)6.7(002)6.7(\))-416.5(L)-1.3(i)12.9(f)-7.4(e)-418.4(a)2.5(n)6.7(d)-420.3(d)6.7(e)-3.6(at)12.9(h)-426(o)6.7(f)-422.6(d)6.7(ri)12.9(ed)-420.3(p)6.7(r)-1.8(o)6.7(-)]TJ .9149 -1.1223 TD .012 Tc [(karyot)12(es.)]TJ /F7 1 Tf 4.0743 0 TD 0 Tc [(R)-8.1(e)-10.4(s)-340.8(M)-14.8(ic)-22.2(ro)-17.7(b)-12.3(i)0(o)-18(l)]TJ /F6 1 Tf 6.2395 0 TD .0062 Tc [(1)-6.1(5)-6.1(3)0(:)-5.6(7)-6.1(1)-6.1(2.)]TJ -11.2287 -1.1284 TD .0115 Tc [(Castro,)-610.7(V)3.7(.A.)5.3(,)-610.7(Th)5.3(ras)11.5(h)-6.2(er,)-610.7(A)-2.4(.N.,)-610.7(Healy,)-610.7(M.)5.3(,)-610.7(O)-2.4(t)11.5(t)-5.9(,)-610.7(C).5(.M.)5.3(,)-610.7(and)]TJ .9149 -1.1223 TD .0119 Tc [(Pi)11.9(erso)5.7(n,)-384.6(D.L.)-384.6(\(2)5.7(00)5.7(4\))-387(Mi)11.9(cro)5.7(b)-.4(ial)-384.1(c)1.5(haracterizatio)5.7(n)-384.7(d)-.4(u)5.7(r)-2.8(in)5.7(g)-384.7(t).1(he)]TJ 0 -1.1284 TD .0113 Tc [(early)-373.1(h)-1(ab)5.1(itati)11.3(o)-6.7(n)-373.1(of)-375.4(th)5.1(e)-377.3(I)2.7(nternat)11.3(i)-6.1(on)5.1(al)-378.6(Space)-377.3(St)11.3(ation)5.1(.)]TJ /F7 1 Tf 21.8109 0 TD .0163 Tc [(Mi)16.3(c)-5.9(r)16.3(ob)]TJ -21.8109 -1.1223 TD .0123 Tc (Ecol)Tj /F6 1 Tf 2.2201 0 TD [(47)6(:11)6(9)-.1()6(126)6(.)]TJ -3.135 -1.1284 TD 0 Tc [(Derecho,)-371.4(I.,)-362.5(McCoy,)-362.8(K.B.,)-360.6(Vaishampayan,)-366(P.,)-363(Venkateswaran,)]TJ .9149 -1.1223 TD [(K.,)-630.1(and)-626.8(Mogul,)-627.7(R.)-627.1(\(2014\))-627.6(Characterization)-632.4(of)-624.7(hydrogen)]TJ 0 -1.1284 TD (peroxide-resistant)Tj /F7 1 Tf 7.6118 0 TD (Acinetobacter)Tj /F6 1 Tf 6.0626 0 TD [(species)-426(isolated)-427.8(during)-423.5(the)]TJ -13.6745 -1.1223 TD [(Mars)-249.4(Phoenix)-245.4(spacecraft)-245.2(assembly.)]TJ /F7 1 Tf 14.3576 0 TD (Astrobiology)Tj /F6 1 Tf 5.4222 0 TD (14:837847.)Tj -20.6947 -1.1284 TD [(Donoghue,)-299.8(N.A.,)-302.5(and)-297.4(Trudgill,)-296.5(P.W.)-300.4(\(1975\))-298.3(The)-299.3(metabolism)-299.2(of)]TJ .9149 -1.1223 TD [(cyclohexanol)-340.7(by)]TJ /F7 1 Tf 7.0263 0 TD (Acinetobacter)Tj /F6 1 Tf 5.9651 0 TD [(NCIB)-337.3(9871.)]TJ /F7 1 Tf 5.3002 0 TD [(FEBS)-335.6(J)]TJ /F6 1 Tf 3.4583 0 TD (60:17.)Tj -22.6648 -1.1284 TD -.0182 Tc [(Drech)6.1(s).8(el)6.6(,)-359.8(H)4.5(.,)-353.7(Thi)6.6(e)-4.2(k)6.1(e)1.9(n,)-353.7(A.,)-353.7(R)1.3(eissbrod)6.1(t).5(,)-359.8(R)1.3(.)6.1(,)-359.8(Ju)6.1(ng,)-353.7(G.)6.1(,)-359.8(a)1.9(nd)-353.8(Wink)6.1(el-)]TJ .9149 -1.1223 TD -.0187 Tc [(mann,)-287.1(G.)-287.1(\(199)5.6(3\))-283.4(Alp)5.6(h)-.5(a-k)5.6(e)1.4(to)-287.2(acids)-286.3(are)-285.3(nov)5.6(el)-280.5(sideroph)5.6(ores)-286.3(i)6.1(n)-287.2(the)]TJ 0 -1.1284 TD -.018 Tc (genera)Tj /F7 1 Tf 2.8544 0 TD -.0184 Tc [(Pro)5.9(t).3(eus)]TJ /F6 1 Tf 2.9764 0 TD 0 Tc (,)Tj /F7 1 Tf .5245 0 TD -.0194 Tc (Providencia)Tj /F6 1 Tf 4.6842 0 TD .2745 Tc [(,a)288.5(n)298.8(d)]TJ /F7 1 Tf 2.2079 0 TD -.017 Tc [(Mo)7.3(rgan)7.3(el)7.8(la)]TJ /F6 1 Tf 4.8245 0 TD -.0224 Tc [(a)-8.5(n)1.9(d)-297(a)-8.4(re)-301.2(pr)-6.6(od)-4.2(u)-4.2(c)-2.4(ed)]TJ -18.072 -1.1223 TD -.0198 Tc [(by)-337.1(amino)-331(a)-5.8(cid)-331(d)-1.6(eaminases.)]TJ /F7 1 Tf 10.9603 0 TD .3154 Tc [(JB)337.8(a)333.6(c)335.4(t)334.1(e)335.5(r)334.4(i)334.1(o)339.7(l)]TJ /F6 1 Tf 4.6537 0 TD -.0182 Tc [(1)6.1(75:2)6.1(727)6.1(273)6.1(3.)]TJ -16.5289 -1.1284 TD 0 Tc [(Du)-386.1(Preez,)-384.6(J.,)-377.6(Toerien,)-385.2(D.,)-380(and)-382.8(Lategan,)-387.1(P.)-375.2(\(1981\))-383.7(Growth)-383.9(pa-)]TJ .9149 -1.1223 TD [(rameters)-376.4(of)]TJ /F7 1 Tf 5.038 0 TD [(Acinetobacter)-377.9(calcoaceticus)]TJ /F6 1 Tf 11.8447 0 TD [(on)-372.3(acetate)-374.6(and)-376.7(eth-)]TJ -16.8827 -1.1284 TD (anol.)Tj /F7 1 Tf 2.3177 0 TD [(Appl)-331.3(Microbiol)-334.7(Biotechnol)]TJ /F6 1 Tf 11.2592 0 TD (13:4553.)Tj -14.4918 -1.1223 TD [(Dworkin,)-323.2(J.,)-322.7(Adelman,)-327.2(L.,)-319.3(Ajluni,)-324.1(T.,)-319.3(Andronikov,)-322(A.,)-325.1(Aponte,)]TJ .9149 -1.1284 TD [(J.,)-481.2(Bartels,)-478.1(A.,)-471.5(Beshore,)-479.3(E.,)-477.9(Bierhaus,)-478.8(E.,)-477.9(Brucato,)-479.6(J.,)-475.1(and)]TJ 0 -1.1223 TD [(Bryan,)-250(B.)-249(\(2018\))-249.5(OSIRIS-REx)-252.9(contamination)-249.7(control)-250.4(strategy)]TJ 0 -1.1284 TD [(and)-340.1(implementation.)]TJ /F7 1 Tf 8.6792 0 TD [(Space)-332.4(Sci)-339.5(Rev)]TJ /F6 1 Tf 6.1358 0 TD (214:19.)Tj -15.7299 -1.1223 TD [(Franca,)-427.4(M.B.,)-425.4(Panek,)-426.9(A.D.,)-424.5(and)-425.5(Eleutherio,)-427.2(E.C.)-428(\(2007\))-420.3(Oxi-)]TJ .9149 -1.1284 TD [(dative)-416.8(stress)-412.8(and)-413.3(its)-413.1(effects)-413.3(during)-411.3(dehydration.)]TJ /F7 1 Tf 20.286 0 TD [(Comp)-409.5(Bio-)]TJ -20.286 -1.1223 TD [(chem)-339.9(Physiol)-334.4(A)-331.4(Mol)-337.8(Integr)-335.3(Physiol)]TJ /F6 1 Tf 14.815 0 TD (146:621631.)Tj -15.7299 -1.1284 TD [(Fr)18.9(ic)14.4(k,)-469.9(A.)22.6(,)-481.9(M)12.8(og)18(ul)18.6(,)-475.8(R)0(.)19.4(,)-481.9(St)21.8(ab)19.9(ek)19.9(is)19.5(,)-481.9(P)0(.)21.3(,)-481.9(C)13.4(o)0(n)18(l)12.6(ey)19.9(,)-481.9(C)0(.)19.4(A)0(.)16.5(,)-475.8(an)19.9(d)-482(E)0(h)22.2(r)0(e)17.6(n)0(-)]TJ .9149 -1.1223 TD [(fr)13.4(e)14(u)0(n)18(d)0(,)-232(P)0(.)-228.8(\()0(2)15.7(0)0(1)18(4)0(\))-228.3(O)0(v)16.4(e)0(r)17.6(v)0(i)24.7(e)0(w)-237.8(o)0(f)-228.3(c)0(u)19.9(r)0(r)19.5(e)0(n)13.8(t)-237.4(ca)15.7(pa)19.9(bi)18.6(l)12.6(i)0(t)19.2(i)0(e)14.4(s)-237.1(an)13.8(d)-238(r)0(e)17.6(s)0(e)20.8(a)0(r)17.6(c)0(h)]TJ 0 -1.1284 TD [(an)13.8(d)-494.2(t)12.6(ec)15.7(hn)18(ol)18.6(og)24.1(y)-500.3(d)0(e)19.9(v)0(e)19.9(l)12.6(op)18(m)12.5(e)0(n)13.8(t)12.6(s)-499.4(f)0(o)21.8(r)-496.5(pl)18.6(an)19.9(et)20.5(ar)17.6(y)-494.2(p)0(r)15.7(o)0(t)24.7(e)0(c)15.7(t)0(i)19.2(o)0(n)18(.)]TJ /F7 1 Tf 23.2686 0 TD [(Ad)16.1(v)]TJ -23.2686 -1.1223 TD [(Sp)18(ac)19.9(e)-327.6(R)0(e)18(s)]TJ /F6 1 Tf 4.4341 0 TD -.018 Tc [(5)-18(4)0(:)-5.4(2)-18(21)-18()6.1(2)-18(40)-18(.)]TJ -5.349 -1.1284 TD 0 Tc (Fu)Tj 9.2951 0 0 9.2951 318.9542 275.4708 Tm ()Tj .4086 -.0122 TD [(zfa)13.2(i,)-207(Z.,)-209.6(Bo)13.2(ld)12.5(izsa)]TJ 6.3615 .0427 TD ()Tj .3782 -.0427 TD [(r,)-209.9(I.,)-203.9(and)-205.9(Mo)12.6(lna)14.2(r-P)16.4(erl)11.9(,)-213.5(I)0(.)-209.9(\(20)15.5(08\))-204(Cha)15(ra)11.5(cter)13.7(is)13.4(tic)]TJ -6.8677 -1.1223 TD [(frag)15(me)14.2(nta)14.2(tio)12.9(n)-262.4(pat)14.2(ter)11.9(ns)-261.7(of)-258.8(th)12.5(e)-266.6(trim)17(eth)14.2(yl)12.5(si)13.4(lyl)-255.5(and)-260.8(tri)16.7(met)14.7(hyl)18.4(sil)13.8(yl)12.5(-)]TJ 0 -1.1284 TD [(oxi)12.3(me)-382.2(de)13.8(riva)17.9(tiv)12.9(es)-381.8(of)-380.8(va)13.8(rio)16.1(us)-383.7(sac)16.4(char)19.2(ide)14.2(s)-389.6(a)0(s)-381.8(obt)18.4(ain)14.2(ed)-382.6(by)-378.4(gas)]TJ T* [(chr)11.3(om)12.3(ato)14.2(gra)17.4(phy)-756.7(cou)13.7(ple)14.2(d)-768.6(t)0(o)-762.1(i)0(o)12.5(n-t)16.1(rap)-757.2(mass)-758.9(sp)12.8(ect)16.1(rom)16(etr)11.9(y.)]TJ /F7 1 Tf 0 -1.1223 TD [(J)-278.8(C)0(h)13.2(rom)11.1(at)12.5(ogr)-267.9(A)]TJ /F6 1 Tf 6.7762 0 TD [(1177)17.7(:1)12.5(83)17.9(189.)]TJ -7.6911 -1.1284 TD [(Ghosh,)-367.5(S.,)-363(Osman,)-365.1(S.,)-369.1(Vaishampayan,)-366(P.,)-363(and)-364.5(Venkateswaran,)]TJ .9149 -1.1223 TD [(K.)-562.9(\(2010\))-566.6(Recurrent)-565.6(isolation)-563.5(of)-563.7(extremotolerant)-563.8(bacteria)]TJ 0 -1.1284 TD [(from)-395.1(the)-394.4(clean)-397(room)-392.8(where)-391.2(Phoenix)-397.9(spacecraft)-397.7(components)]TJ 0 -1.1223 TD [(were)-336.1(assembled.)]TJ /F7 1 Tf 7.0446 0 TD (Astrobiology)Tj /F6 1 Tf 5.5076 0 TD (10:325335.)Tj -13.4671 -1.1284 TD [(Hanzel,)-465.9(J.,)-462.9(Thullner,)-459.9(M.,)-463.1(Harms,)-458.9(H.,)-465.4(and)-456(Wick,)-466.1(L.Y.)-461.3(\(2011\))]TJ .9149 -1.1223 TD [(Microbial)-314.5(growth)-309.2(with)-306(vapor-phase)-310.7(substrate.)]TJ /F7 1 Tf 18.8161 0 TD [(Environ)-310.6(Pollut)]TJ /F6 1 Tf -18.8161 -1.1284 TD (159:858864.)Tj -.9149 -1.1223 TD .2989 Tc [(I)284.2(c)288.5(h)292.7(i)287.1(s)287.4(e)288.5(,N)285(.)292.7(,)-6.1(M)298.9(o)281.1(r)290.3(i)287.1(t)287.1(a)288.5(,N)285(.)292.7(,)0(H)285(o)292.7(s)287.4(h)286.6(i)287.1(n)292.7(o)286.6(,)0(T)290.8(.)286.6(,K)285(a)288.5(w)291.1(a)288.5(s)287.4(a)288.5(k)286.6(i)287.1(,)0(K)291.1(.)286.6(,Y)285(u)292.7(m)287(o)286.6(t)298.9(o)280.9(,)0(I)290.3(.)286.6(,)]TJ .9149 -1.1284 TD .0107 Tc [(a)-5.8(n)4.5(d)-538.4(O)2.9(kuyama,)-538.3(H.)-538.3(\(1999\))-534.6(A)-533.8(m)-1.2(echani)10.7(s)-6.4(m)-537.9(o)-1.6(f)-534.6(r)2.1(esist)10.7(a)-5.4(nce)-536.5(t)-1.1(o)]TJ 0 -1.1223 TD .0121 Tc [(hyd)5.9(ro)5.9(gen)-360.1(p)-.2(erox)5.9(ide)-364.3(i)12.1(n)]TJ /F7 1 Tf 9.3501 0 TD .0111 Tc [(Vib)4.9(r)-.4(io)-361.1(rumoien)4.9(s)-.4(is)]TJ /F6 1 Tf 7.8314 0 TD .0077 Tc [(S-)-7(1.)]TJ /F7 1 Tf 2.0432 0 TD .0094 Tc [(Appl)-368.3(Envir)9.4(o)-8.3(n)]TJ -19.2248 -1.1284 TD 0 Tc [(M)-14.8(i)0(c)-22.2(r)0(o)-17.7(b)-12.3(io)-18(l)]TJ /F6 1 Tf 4.4341 0 TD .0062 Tc [(6)-6.1(5)-6.1(:)6.2(7)-11.8(3)-6.1(7)-6.1(9.)]TJ -5.349 -1.1223 TD 0 Tc [(Kunz,)-384.6(D.A.,)-381.8(and)-376.7(Weimer,)-387.1(P.J.)-380.6(\(1983\))-377.6(Bacterial)-383.4(formation)-386.7(and)]TJ .9149 -1.1284 TD [(metabolism)-402.8(of)-399.1(6-hydroxyhexanoate:)-407.4(evidence)-401.7(of)-399(a)-400.8(potential)]TJ 0 -1.1223 TD [(role)-335.9(for)-334.4(omega-oxidation.)]TJ /F7 1 Tf 10.7834 0 TD [(J)-333.7(Bacteriol)]TJ /F6 1 Tf 4.855 0 TD (156:567575.)Tj -16.5533 -1.1284 TD [(La)-256.5(Du)16.4(c)14(,)-262.3(M.)18.8(T.)16.2(,)-262.3(D)0(e)18.3(k)0(a)19.9(s)12.9(,)-262.3(A)0(.)16.5(,)-262.3(Os)17.3(m)12.5(a)0(n)19.9(,)-262.3(S.)15.2(,)-262.3(M)12.8(oi)18.6(ss)19.8(l,)-255.8(C)13.4(.)0(,)-256.3(N)0(e)18.3(w)0(c)18.3(o)0(m)24.5(b)0(e)19.9(,)-262.3(D.)16.5(,)]TJ .9149 -1.1223 TD [(an)13.8(d)-390.5(V)0(e)18.3(n)0(k)18(a)0(t)20.5(e)0(s)14.7(w)0(a)18.3(r)0(a)17.6(n)0(,)-384.5(K)0(.)-386(\()0(2)21.8(0)0(0)18(7)0(\))-386.9(I)0(s)22.7(o)0(l)18.6(a)0(t)20.5(i)0(o)18.6(n)-396.6(an)19.9(d)-396.6(c)0(h)19.9(a)0(r)17.6(a)0(c)21.8(t)0(e)14.4(r)0(i)22.4(z)0(a)15.7(t)12.6(io)18.6(n)]TJ /F5 1 Tf 8.9663 0 0 8.9663 62.022 749.6502 Tm (10)Tj 47.3776 0 TD [(MOGUL)-332.3(ET)-338.7(AL.)]TJ ET endstream endobj 103 0 obj <>stream 0 0 0 rg /GS1 gs 310.847 279.213 239.074 .51025 re f 310.847 170.646 239.074 .45352 re f 310.847 170.646 .51022 109.077 re f 549.468 170.646 .45349 109.077 re f BT /F6 1 Tf 9.2951 0 0 9.2951 68.2582 725.1588 Tm .0187 Tc 0 Tw [(o)-5.8(f)-490(bact)-5.3(eri)-5.3(a)-491.9(capabl)-5.3(e)-491.9(o).3(f)-490(t).8(o)-5.8(l).8(erat)-5.3(ing)-493.8(t).8(he)-491.9(ext)-5.3(r)-2.1(em)-5.4(e)-491.9(c)2.2(o)-5.8(ndit)-5.3(i).8(on)-5.8(s)]TJ 0 -1.1223 TD .0177 Tc [(o)-6.8(f)-387.3(cl)-6.3(ea)-4.9(n)-385(r)-3.1(o)-6.8(o)-.7(m)-384.6(e)-4.9(nv)-6.8(ironm)-6.4(en)-6.8(ts.)]TJ /F7 1 Tf 12.8023 0 TD .019 Tc [(Appl)-389.2(Envir)-4.6(o).6(n)-383.7(M)-1.9(i)-5(c)2.5(r)-4.6(obi)-5(ol)]TJ /F6 1 Tf 10.6859 0 TD .0245 Tc [(73)6.1(:)]TJ -23.4881 -1.1284 TD .0184 Tc [(2)-6.1(600)-6.1(2611)-6.1(.)]TJ -.9149 -1.1223 TD 0 Tc [(La)-457.7(Duc,)-451.5(M.T.,)-453(Kern,)-454(R.,)-450.3(and)-456(Venkateswaran,)-460.1(K.)-453.1(\(2004\))-450.8(Mi-)]TJ .9149 -1.1283 TD [(crobial)-620.5(monitoring)-611.5(of)-618.6(spacecraft)-617.3(and)-614.6(associated)-619.2(environ-)]TJ 0 -1.1223 TD (ments.)Tj /F7 1 Tf 2.9825 0 TD [(Microb)-335.4(Ecol)]TJ /F6 1 Tf 5.4588 0 TD (47:150158.)Tj -9.3562 -1.1284 TD .0116 Tc [(La)-364.8(Duc,)-360.5(M.)5.4(T.)5.4(,)-366.6(N)3.8(icho)5.4(lso)5.4(n)-.7(,)-360.5(W)1(.,)-360.5(Kern,)-360.5(R).6(.,)-360.5(and)-360.6(V)3.8(enkates)11.6(w)-7.7(aran,)]TJ .9149 -1.1223 TD .0104 Tc [(K.)-392.2(\(2003\))-394.6(M)10.4(i)-6.9(crobial)-391.7(c)0(haracterization)-392.3(o)-1.9(f)-394.6(t)-1.4(he)-396.5(Mars)-397.5(Odyssey)]TJ 0 -1.1284 TD [(spacecraft)-324.6(a)0(nd)-325.2(its)-324.3(enc)-6.1(a)0(psul)10.4(a)-5.7(tion)-319.1(f)-4.3(acil)10.4(i)-7(ty.)]TJ /F7 1 Tf 17.0962 0 TD .0122 Tc [(En)6(viro)6(n)-323.4(M)-2.6(i)12.2(c)-3.9(rob)6(i).4(ol)]TJ /F6 1 Tf -17.0962 -1.1223 TD [(5:9)6(77)6(98)6(5.)]TJ -.9149 -1.1284 TD 0 Tc [(La)-286.9(Duc,)-280.8(M.T.,)-282.2(Vaishampayan,)-286.7(P.,)-283.8(Nilsson,)-286.4(H.R.,)-281.3(Torok,)-285.6(T.,)-282.7(and)]TJ .9149 -1.1223 TD [(Venkateswaran,)-332(K.)-325.1(\(2012\))-322.7(Pyrosequencing-derived)-324.8(bacterial,)]TJ 0 -1.1284 TD [(archaeal,)-249.7(and)-248.6(fungal)-244.7(diversity)-243.1(of)-246.6(spacecraft)-245.2(hardware)-251.8(destined)]TJ T* [(for)-334.4(Mars.)]TJ /F7 1 Tf 4.1353 0 TD [(Appl)-337.4(Environ)-335(Microbiol)]TJ /F6 1 Tf 10.1369 0 TD (78:59125922.)Tj -15.1871 -1.1223 TD .0124 Tc [(Mahn)6.2(ert,)-432.9(A.)6.2(,)-439(V)-1.5(ai)12.4(shamp)6.2(a)2(yan,)-432.9(P.)6.2(,)-439(P)3.3(robs)12.4(t,)-439(A.J.)6.2(,)-439(A)-1.5(u)6.2(e)2(rb)6.2(ach,)-439(A)4.6(.,)]TJ .9149 -1.1284 TD .0084 Tc [(M)-3.2(o)-3.9(i)-3.4(s)8.4(s)-8.4(l)-3.4(-E)-5.8(i)8.4(c)-7.7(h)-3.9(i)-3.4(ng)-3.9(er,)-619.9(C)-2.6(.)-3.9(,)-619.9(V)-5.5(e)-2(nk)-3.9(at)-3.4(es)-3(wara)-8.1(n,)-619.9(K)-5.5(.)2.2(,)-626(a)-2(nd)-620(Ber)-6.3(g)2.2(,)-619.9(G)-5.5(.)]TJ 0 -1.1223 TD .0118 Tc [(\(2)5.6(01)5.6(5\))-362.7(Cl)11.8(e)-10.4(a)1.4(n)5.6(r)3.2(oom)-360(m)11.8(a)-10.6(i)11.8(n)-6.2(ten)5.6(a)1.4(nce)-364.6(s)11.8(ign)5.6(i)0(cantl)11.8(y)-366.1(r)-2.9(ed)5.6(uces)-359.5(abun)5.6(-)]TJ 0 -1.1284 TD .0122 Tc [(dance)-394.7(b)6(ut)-389.9(not)-389.9(div)6(e)1.8(rs)12.2(ity)-390.5(o)-.1(f)-392.8(i).4(n)6(doo)6(r)-392.8(m).3(icrob)6(i).4(om)12.2(e)-10.2(s)12.2(.)]TJ /F7 1 Tf 20.5239 0 TD .0105 Tc [(PLoS)-392.2(O)-3.4(n)4.3(e)]TJ /F6 1 Tf -20.5239 -1.1223 TD .0126 Tc [(10:)12.6(e013)6.4(48)6.4(48.)]TJ -.9149 -1.1284 TD .0112 Tc [(McCoy)5(,)-403.6(K.,)-397.5(D)3.4(erech)5(o,)-397.5(I.,)-397.5(W).6(on)5(g,)-397.5(T.,)-397.5(T)-3(ran,)-397.5(H.,)-397.5(H)3.4(uyn)5(h,)-397.5(T.,)-397.5(L)3.1(a)]TJ .9149 -1.1223 TD .0126 Tc [(Du)6.4(c,)-280.2(M)12.6(.)-5.2(,)-280.2(V)-1.3(en)6.4(kateswaran)6.4(,)-280.2(K)-1.3(.)6.4(,)-280.2(an)6.4(d)-280.3(M)1(og)6.4(ul,)-280.2(R)1.6(.)-280.2(\()4(20)6.4(12\))-276.5(In)6.4(sig)6.4(h).3(ts)]TJ 0 -1.1284 TD 0 Tc [(i)-11.8(n)-12.3(to)-499.8(th)-18(e)-492.3(e)-10.4(x)-6.2(t)-11.8(r)-8.6(e)-10.4(m)-11.9(o)-12.3(to)-18(l)-11.8(e)-10.4(r)-8.6(a)-10.4(n)-12.3(c)-10.4(e)-486.2(o)-12.3(f)]TJ /F7 1 Tf 12.7718 0 TD .0089 Tc [(Aci)-2.9(n)-3.4(et)-2.9(ob)-3.4(act)-2.9(e)-1.5(r)-484.4(r)8.9(a)-8.8(d)-3.4(i)8.9(o)-9.1(r)-2.5(e)-1.5(s)-2.6(i)8.9(s)-8.2(t)-2.9(en)-3.4(s)]TJ /F6 1 Tf -12.7718 -1.1223 TD .0117 Tc [(50v)5.5(1,)-494.6(a)-492.8(g)-.6(ram-negat)11.7(i)-5.7(ve)-492.8(bacteriu)5.5(m)-500.3(i)11.7(sol)11.7(a)-10.5(t)11.7(e)-4.4(d)-494.7(f)-3(rom)-494.2(t)11.7(h)-6.3(e)-498.9(M)11.7(a)-4.2(rs)]TJ 0 -1.1284 TD .01 Tc [(Odyssey)-331.7(s)-1.4(pa)-6.5(cecraft.)]TJ /F7 1 Tf 8.606 0 TD 0 Tc [(A)-14.2(s)-11.4(tr)-17.1(o)-12.3(b)-6.2(i)-11.8(o)-12.3(lo)-18(g)-12.3(y)]TJ /F6 1 Tf 5.6296 0 TD .0123 Tc [(12:)12.3(8)-5.7(5)0(4)6.1()0(8)6.1(62.)]TJ -15.1505 -1.1223 TD .0112 Tc [(Mod)5(r)-3.5(zy)5(n)]TJ 3.3119 .0427 TD 0 Tc ()Tj .4269 -.0427 TD .0111 Tc [(sk)4.9(i,)-489.1(J.J)11.1(.)-6.5(,)-489.1(C).1(hrist)11.1(e)-5(nsen)4.9(,)-495.2(J)11.1(.)-6.5(H)3.3(.,)-489.1(Mayer,)-489.1(P.,)-489.1(a).7(nd)-489.2(Brand)4.9(t)-.7(,)]TJ -2.8239 -1.1284 TD .0118 Tc [(K.)5.6(K.)-244.4(\(2)5.6(01)5.6(6\))-246.8(Limit)11.8(e)-10.4(d)-244.5(r)3.2(ecovery)-244.5(of)-246.8(so)5.6(il)-250(m)11.8(i)-5.8(crobi)11.8(al)-250(activ)5.6(ity)-244.5(after)]TJ 0 -1.1223 TD .0105 Tc [(transient)-391.6(e).1(xposure)-390.3(t)10.5(o)-397.9(g)4.3(asoli)10.5(n)-7.5(e)-390.3(v)-1.8(apors.)]TJ /F7 1 Tf 16.4008 0 TD .0138 Tc [(En)7.6(vi)13.8(r)-3.3(o)1.5(n)-382.8(P)-.4(o)7.6(llu)7.6(t)]TJ /F6 1 Tf 6.5994 0 TD .0123 Tc [(21)6.1(6:)]TJ -23.0002 -1.1284 TD [(826)6.1(8)6.1(35.)]TJ -.9149 -1.1223 TD 0 Tc [(Moissl,)-418.1(C.,)-419.8(Osman,)-420(S.,)-411.8(La)-421.1(Duc,)-414.9(M.T.,)-416.4(Dekas,)-418.6(A.,)-416.6(Brodie,)-420.3(E.,)]TJ .9149 -1.1284 TD [(DeSantis,)-359.7(T.,)-349.8(and)-352.3(Venkateswaran,)-362.5(K.)-349.4(\(2007\))-353.2(Molecular)-355.9(bac-)]TJ 0 -1.1223 TD [(terial)-424.6(community)-424.4(analysis)-427.5(of)-423.4(clean)-421.4(rooms)-428.7(where)-421.7(spacecraft)]TJ 0 -1.1284 TD [(are)-340.5(assembled.)]TJ /F7 1 Tf 6.3249 0 TD [(FEMS)-336.2(Microbiol)-334.7(Ecol)]TJ /F6 1 Tf 9.4172 0 TD (61:509521.)Tj -16.657 -1.1223 TD .0121 Tc [(Mois)12.1(sl-Ei)12.1(c)-4(hin)5.9(g)-.2(er,)-268.5(C)1.1(.,)-262.4(Pu)5.9(kall)12.1(,)-274.2(R)1.1(.,)-262.4(Prob)5.9(st,)-262.4(A)-1.8(.J)12.1(.)-5.5(,)-268.5(Sti)12.1(e)-4(glmei)12.1(e)-4(r,)-268.5(M)12.1(.)-5.7(,)]TJ .9149 -1.1284 TD .0102 Tc [(Schwendner,)-325.3(P.,)-325.3(M)10.2(o)-7.6(r)1.6(a,)-325.3(M.,)-325.3(B)-.8(arczyk,)-325.3(S.,)-325.3(B)-.8(ohmeier,)-325.3(M.,)-325.3(a)-.2(nd)]TJ 0 -1.1223 TD .0085 Tc [(Ret)-3.3(t)-3.3(b)2.3(e)-8(r)-.1(g,)-571(P.)-571(\(20)-3.8(1)-3.8(3)2.3(\))-567.3(L)-5.7(es)-2.9(s)-2.9(o)2.3(n)-3.8(s)-570.2(l)8.5(e)-7.6(ar)-6.2(ned)-571.1(fro)-3.8(m)-570.6(t)8.5(h)-9.5(e)-569.2(m)-3.4(i)8.5(c)-7.6(r)-6.2(ob)-3.8(i)-3.3(a)-1.9(l)]TJ 0 -1.1284 TD .0102 Tc [(analysis)-422.1(of)-425.3(the)-421.1(H)-3.7(erschel)-416.3(s)-1.2(pacecraft)-416.3(during)-423(a)-.2(ssem)10.2(b)-8(ly,)-422.9(i)-1.6(nte-)]TJ 0 -1.1223 TD .0112 Tc [(gratio)5(n,)-330.4(and)-330.5(t)-.6(est)-329.9(operati)11.2(o)-6.8(n)-1.1(s)11.2(.)]TJ /F7 1 Tf 11.9606 0 TD .0114 Tc [(Astro)5.2(b)-.9(i)11.4(o)-6.6(lo)5.2(gy)]TJ /F6 1 Tf 5.6296 0 TD .0122 Tc [(1)6(3)-.1(:1)6(125)6(1)6(139)6(.)]TJ -18.5051 -1.1284 TD 0 Tc [(NASA.)-606(\(2011\))-603.2(Planetary)-609.6(Protection)-605(Provisions)-607.6(for)-602.8(Robotic)]TJ .9149 -1.1223 TD [(Extraterrestrial)-563.3(Missions.)-557.8(National)-558.4(Aeronautics)-565(and)-553.6(Space)]TJ 0 -1.1284 TD [(Administration.)-585.5(Available)-587.1(online)-577.3(at)-583.3(http://nodis3.gsfc.nasa)]TJ 0 -1.1223 TD [(.go)17.9(v/)12.5(di)12.5(spl)13.2(ay)13.8(Dir)14.5(.c)13.9(fm?)17.9(Int)16.1(er)11.5(nal)14.2(_I)15.7(D=)11.3(N_P)13.4(R_)13.2(802)17.9(0_0)17.9(12D)16.3(_&)12.3(pa)13.8(ge)13.8(_)]TJ 0 -1.1284 TD [(nam)14.1(e=m)15.1(ai)14.4(n&)12.4(sea)16.4(rc)11.5(h_t)18.4(er)11.5(m=8)13.2(020)17.9(%2)15.5(E12)]TJ -.9149 -1.1223 TD [(Nishimura,)-488.9(Y.,)-477.6(Ino,)-484.7(T.,)-477.9(and)-486.5(Iizuka,)-480.7(H.)-483.6(\(1988\))]TJ /F7 1 Tf 20.0909 0 TD (Acinetobacter)Tj -19.176 -1.1284 TD (radioresistens)Tj /F6 1 Tf 5.9041 0 TD [(sp.)-237.3(nov.)-232.3(isolated)-238.7(from)-236.5(cotton)-235.7(and)-236.4(soil.)]TJ /F7 1 Tf 15.2603 0 TD [(Int)-233.9(J)-236.1(Syst)]TJ -21.1643 -1.1223 TD [(Evol)-335.5(Microbiol)]TJ /F6 1 Tf 6.5201 0 TD (38:209211.)Tj -7.435 -1.1284 TD [(Pirog,)-292.1(T.,)-288.8(and)-285.2(Kuzminskaya,)-297(Y.V.)-290.3(\(2003\))-286.1(Some)-287.8(characteristics)]TJ .9149 -1.1284 TD [(of)-283.2(central)-283.2(metabolism)-280.9(in)]TJ /F7 1 Tf 10.1613 0 TD (Acinetobacter)Tj /F6 1 Tf 5.9163 0 TD [(sp.)-280(grown)-279.1(on)-280.8(ethanol.)]TJ /F7 1 Tf -16.0776 -1.1223 TD (Microbiology)Tj /F6 1 Tf 5.7943 0 TD (72:408413.)Tj -6.7092 -1.1284 TD [(Schoeld,)-240.5(C.J.,)-236.2(and)-236.4(Zhang,)-238.7(Z.)-240(\(1999\))-237.3(Structural)-235.2(and)-242.5(mechanistic)]TJ .9149 -1.1223 TD [(studies)-386.6(on)-384.5(2-oxoglutarate-dependent)-387.2(oxygenases)-390.5(and)-382.8(related)]TJ 0 -1.1284 TD (enzymes.)Tj /F7 1 Tf 4.0987 0 TD [(Curr)-332.9(Opin)-330.9(Struct)-338.5(Biol)]TJ /F6 1 Tf 9.3379 0 TD (9:722731.)Tj -14.3515 -1.1223 TD [(Sc)17(hu)18(er)17.6(ge)19.9(r,)-429.5(A.)16.5(C)13.4(.)0(,)-433.2(U)0(l)17(r)0(i)22.4(c)0(h)19.9(,)-439.2(R.)19.4(,)-445.3(B)13.4(er)17.6(ry)15.7(,)-439.2(B)0(.)19.4(J)12.9(.,)-433.2(an)19.9(d)-439.3(N)0(i)17(c)0(h)19.9(o)0(l)18.6(s)0(o)18.9(n)0(,)-433.3(W)13.8(.L)16.2(.)]TJ .9149 -1.1284 TD [(\(2)15.7(01)24.1(3\))-234.4(Gr)20.2(ow)16.4(t)12.6(h)-244.1(of)]TJ /F7 1 Tf 7.1727 0 TD [(Se)19.9(rr)19.8(at)18.6(ia)-231.5(li)19.2(qu)18(ef)20.5(ac)13.8(i)12.6(e)0(n)19.9(s)]TJ /F6 1 Tf 8.4413 0 TD [(un)18(de)19.9(r)-240.3(7)-244.1(mb)18.4(ar)17.6(,)-244(0)]TJ /F8 1 Tf 6.2334 0 TD ()Tj /F6 1 Tf .3843 0 TD [(C,)-236.8(an)19.9(d)]TJ -22.2317 -1.1223 TD (CO)Tj 6.9712 0 0 6.196 80.9575 169.2283 Tm (2)Tj 9.2951 0 0 9.2951 84.359 170.759 Tm [(-e)17.6(nr)21.8(ic)14.4(he)19.9(d)-323.4(a)0(n)19.9(o)0(x)18(i)12.6(c)-327.6(a)14(tm)19(os)18.9(ph)18(er)17.6(e)14(s)0(.)]TJ /F7 1 Tf 12.4607 0 TD -.0187 Tc [(A)-18.7(s)-1.7(t)-6.1(r)-18.7(ob)-18.7(io)-18.7(lo)-18.7(g)5.4(y)]TJ /F6 1 Tf 5.3917 0 TD 0 Tc [(13)24.1(:1)18.6(15)18(1)18(31)24.1(.)]TJ 6.514 59.6444 TD [(Singer,)-266(M.,)-261.8(and)-266.9(Finnerty,)-265.7(W.)-260.7(\(1985\))-267.8(Alcohol)-261.8(dehydrogenases)-269.5(in)]TJ /F7 1 Tf .9149 -1.1223 TD (Acinetobacter)Tj /F6 1 Tf 6.2151 0 TD [(sp.)-578.9(strain)-584.8(HO1-N:)-580.7(role)-579.9(in)-579.1(hexadecane)-587.8(and)]TJ -6.2151 -1.1284 TD [(hexadecanol)-339.2(metabolism.)]TJ /F7 1 Tf 10.6249 0 TD [(J)-333.7(Bacteriol)]TJ /F6 1 Tf 4.855 0 TD (164:10171024.)Tj -16.3947 -1.1223 TD .008 Tc [(Sp)-4.3(ace)-356.2(St)-3.8(ud)-4.3(i)-3.8(e)-2.4(s)-357.2(B)-3(oa)-8.5(rd.)-358(\()-6.7(20)-4.3(00)-4.3(\))-360.4(P)-1.1(rev)-4.3(e)-2.4(nt)-3.8(i)-3.8(n)1.8(g)-358.1(t)-3.8(h)-4.3(e)-356.2(fo)-4.3(rw)-5.9(ard)-358.1(c)-2.4(on)-4.3(t)-3.8(a)-2.4(m)-3.9(-)]TJ .9149 -1.1283 TD .0115 Tc [(in)5.3(atio)5.3(n)-513.2(o)-.8(f)-509.4(E)-2.7(u)5.3(r)2.9(opa.)-507(N)-2.4(atio)5.3(nal)-512.6(A)3.7(cademy)-513.2(P)2.4(ress,)-507(Was)11.5(h)-6.2(in)5.3(gto)5.3(n)]TJ 0 -1.1223 TD .0105 Tc (D.C.)Tj -.9149 -1.1284 TD 0 Tc [(Space)-388.3(Studies)-390.3(Board.)-384.2(\(2006\))-389.8(Preventing)-386(the)-388.3(forward)-385.8(contami-)]TJ .9149 -1.1223 TD [(nation)-308.9(of)-307.6(Mars.)-310.5(National)-314.4(Academies)-316.7(Press,)-307.3(Washington)-312.9(D.C.)]TJ -.9149 -1.1284 TD .0172 Tc [(Vais)5.7(ha)6.8(mp)4.9(ayan)4.9(,)-562.3(P)2(.,)-562.3(Osm)5.3(a).7(n,)-562.3(S.)4.9(,)-562.3(A)3.3(nd)4.9(ersen)4.9(,)-562.3(G.)4.9(,)-562.3(a).7(nd)-562.4(Ven)4.9(k)-1.2(a-)]TJ .9149 -1.1223 TD .0142 Tc [(tes)-3.4(w).3(aran,)-260.3(K)-5.8(.)-260.3(\()-.5(20)-4.2(10)-4.2(\))-256.6(H).3(i)-3.7(g)1.9(h)-4.2(-)-.5(den)-4.2(s)2.8(i)-3.7(t)2.4(y)-260.4(1)-4.2(6S)-263.3(mi)-3.7(croarray)-260.4(an)-4.2(d)-260.4(c)3.8(l)-3.7(o)1.9(n)-4.2(e)]TJ 0 -1.1284 TD .0137 Tc [(li)-4.2(brary)-4.7(-)-1(bas)-3.9(e)-2.8(d)-675.7(m)-4.3(icro)-4.7(bi)-4.2(al)-675.1(com)-4.3(m)1.8(u)-4.7(n)1.4(i)-4.2(t)1.9(y)-681.7(c)-2.8(om)-4.3(pos)-3.9(i)-4.2(t)1.9(i)-4.2(o)1.4(n)-675.7(o)-4.7(f)-678(t)1.9(h)-4.7(e)]TJ 0 -1.1223 TD .0174 Tc [(Phoe)7(nix)-342.6(s)5.9(pacec)7(ra)7(ft)-335.9(as)]TJ 9.1489 0 TD .0161 Tc [(sembly)-337.8(clean)-337.8(room.)]TJ /F7 1 Tf 8.6487 0 TD .0177 Tc [(Astr)6.2(ob)5.4(io)5.4(lo)5.4(gy)]TJ /F6 1 Tf 5.6967 0 TD .0184 Tc [(10)6.1(:)]TJ -23.4943 -1.1284 TD .0123 Tc [(49)-6.1(95)-6.1(08)-6.1(.)]TJ -.9149 -1.1284 TD 0 Tc [(Vaishampayan,)-445.3(P.,)-442.3(Probst,)-443.9(A.J.,)-440.3(La)-445.5(Duc,)-445.4(M.T.,)-440.8(Bargoma,)-449.2(E.,)]TJ .9149 -1.1223 TD [(Benardini,)-625.7(J.N.,)-623.3(Andersen,)-622.6(G.L.,)-626.1(and)-626.8(Venkateswaran,)-624.7(K.)]TJ 0 -1.1284 TD [(\(2013\))-286.1(New)-294.5(perspectives)-292.4(on)-286.9(viable)-288.7(microbial)-290.5(communities)-293.2(in)]TJ 0 -1.1223 TD 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